Category: 288-14-2

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.288-14-2,Isoxazole,as a common compound, the synthetic route is as follows.

288-14-2, Example 1 Preparation of 3-(4-Chlorophenyl)-4-Phenyl Isoxazole (Compound of the Formula I wherein R1=H, Y=4-phenyl and Z=4-chlorophenyl). A solution of phenylacetylene (10 mmol), 4-chlorobenzaldoxime (10 mmol) and chloramine-T (10 mmol, N-chloro-p-toluenesulfoneamide, sodium salt) were dissolved in methanol (40 mL) and refluxed for 6 h. The contents of the flask were cooled and the precipitated material, which was a mixture of isoxazole and 4-toluenesulfonamide, was filtered and washed with water. The solid material on boiling in hot water kept the sulfonamide in solution while precipitating the isoxazole. The precipitated isoxazole was filtered and recrystallized from ethanol, yield (82%), m.p.: 178-180 C.; 1H NMR (DMSO-d6) 6.75(s, 1H), 7.49-7.55(m, 5H), 7.77-7.82 (m, 4H).

As the paragraph descriping shows that 288-14-2 is playing an increasingly important role.

Reference£º
Patent; Onconova Therapeutics, Inc.; US2003/162813; (2003); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

288-14-2, Isoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General Procedure 49 Isoxazole (0.64 mL, 10 mmol) was added to a solution of N-iodosuccinimide (2.3 g, 10 mmol) in trifluoroacetic acid (20 mL). After stirring overnight, water (50 mL), hexanes (50 mL) and sodium bisulfite were added to the reaction. The phases were separated and the organic phase was dried over Na2SO4, filtered and concentrated by rotary evaporation to give 4-iodo-isoxazole (218 mg, 11%)., 288-14-2

288-14-2 Isoxazole 9254, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; AGOURON PHARMACEUTICALS, INC.; US2006/46991; (2006); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

288-14-2, Isoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To the solution of 4a (Ig, 14.5mmol) in trifluoroacetic anhydride (7mL, 50.7mmol) was added ammonium nitrate (1.8g, 22.5mmol) in 0.3g each portion, keeping the reaction temperature between 25-3O0C. After the addition was complete, the mixture was poured into ice water and extracted with DCM (15mLx4). The extract was washed with water and the aqueous layer was extracted with DCM. The combined DCM extract was dried over MgSO4, filtered and concentrated to give a yellow green oil. The oil was triturated by hexane (cooled to 50C) to provide a solid which was filtered to provide 4b (0.72g, 44%).

288-14-2, The synthetic route of 288-14-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; XCOVERY, INC.; WO2009/154769; (2009); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

288-14-2, Isoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 12 4-[5-Benzyloxymethyl-3-(4-fluoro-phenyl)-isoxazol-4-yl]-2-methylsulfanyl-pyrimidine (Compound 8). To a stirred solution of the above compound 7 (13.75 g, 47.7 mmol) and Et3N (14.6 mL, 105 mmol) in EtOH (200 mL), was added a solution of 4-fluoro-benzoylchloride oxime (56 mmol) in EtOH (50 mL) over 30 min. The solution was stirred at 25 C. for 15 min. Then, the solution was heated to reflux for 90 min. The solution was cooled to 25 C. Additional Et3N (7.3 mL, 52 mmol) was added followed by dropwise addition of a solution of 4-fluoro-benzoylchloride oxime (38.5 mmol) in EtOH (50 mL) over 1 h. to drive the reaction to completion. The solution was refluxed for 1 h. until TLC indicated that all of the starting isoxazole was consumed. The solution was cooled to 25 C. and concentrated. The crude material was picked up in CH2Cl2 (50 mL) and poured into saturated aqueous NaHCO3 (150 mL), extracted with CH2Cl2 (3*150 mL), dried (MgSO4), filtered and concentrated. Flash chromatography (SiO2, 20% EtOAc-hexanes) provided the title compound (14.2 g, 34.8 mmol, 60%) in sufficient purity (>85%) for use in the next reaction.

288-14-2, The synthetic route of 288-14-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Green, Jeremy; Bemis, Guy; Grillot, Anne-Laure; Ledeboer, Mark; Salituro, Francesco G.; Harrington, Edmund; Gao, Huai; Baker, Christopher; Cao, Jingrong; Hale, Michael; US2003/149051; (2003); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

288-14-2, Isoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General Procedure 49 Isoxazole (0.64 mL, 10 mmol) was added to a solution of N-iodosuccinimide (2.3 g, 10 mmol) in trifluoroacetic acid (20 mL). After stirring overnight, water (50 mL), hexanes (50 mL) and sodium bisulfite were added to the reaction. The phases were separated and the organic phase was dried over Na2SO4, filtered and concentrated by rotary evaporation to give 4-iodo-isoxazole (218 mg, 11%).

288-14-2, As the paragraph descriping shows that 288-14-2 is playing an increasingly important role.

Reference£º
Patent; AGOURON PHARMACEUTICALS, INC.; US2006/46991; (2006); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

288-14-2, Isoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 16 3beta-(4-Methylphenyl)-2beta-(3-methylisoxazol-5-yl)tropane Hydrochloride (RTI-171) Reaction of 1.09 g (4 mmol) of 3beta-(4-Methylphenyl)-2beta-(carbomethoxy)tropane as described above for RTI-165 gave after workup 1.21 g crude isoxazole. Purification of the crude by flash column chromatography (15% CMA in methylene chloride) gave 0.73 g (62%) pure isoxazole (RTI-171): 1H NMR (CDCl3) delta 1.73 (m, 3H), 2.11 (m, 3H), 2.17 (s, 3H), 2.23 (s, 3H), 2.25 (s, 3H), 3.20 (m, 2H), 3.32 (m, 2H), 6.13 (s, 1H), 6.97 (m, 4H); IR (CCl4) 2935,.2785, 1590, 1510, 1460, 1421, 1350, 1125,1010, 910 cm-1. The isoxazole was crystallized as the hydrochloride salt: 1H NMR (MeOD) delta 2.01 (s, 3H), 2.24 (s, 3H), 2.32 (m, 2H), 2.42 (m, 4H), 2.81 (s, 3H), 3.61 (m, 1H), 3.78 (m, 1H), 4.03 (m, 1H), 4.15 (m, 1H), 5.45 (s, 1H), 6.96 (m, 4H); mp 277 C.; Anal calcd for C19H25CIN2O; C=68.55, H=7.57, N=8.42, Cl=10.65; found C=68.65, H=7.62, N=8.42, Cl=10.56; [alpha]D -107.28 (c-0.71, MEOH).

288-14-2, As the paragraph descriping shows that 288-14-2 is playing an increasingly important role.

Reference£º
Patent; Research Triangle Institute; US6531483; (2003); B1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem