Category: 1072-67-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1072-67-9,5-Methylisoxazol-3-amine,as a common compound, the synthetic route is as follows.

PREPARATIVE EXAMPLE 13.23; Step A; To a stirred solution of acid (630mg) from Preparative Example 13.19, Step B in CH2CI2 (25mi) was added oxalyl chloride (235ul) followed by a catalytic amount of DMF (10ul). The mixture was stirred for 1 hr, then potassium carbonate (1.8g) was added followed by 3-amino-5-methylisoxazole (443mg). The reaction stirred overnight and was quenched with water (25ml). Layers were separated and the organic layer was washed with brine, dried over Na2SO4, and concentrated in vacuo. The crude product was purified by preparative plate chromatography (CH2CI2) to afford the product (580mg, 78%, MH+=317,319).

1072-67-9 5-Methylisoxazol-3-amine 66172, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Patent; SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2005/66147; (2005); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

1072-67-9, 5-Methylisoxazol-3-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a suspension of 4-hydroxyquinolin-2(1H)-one (7, 1 mmol, 161 mg) in H2O:EtOH(1:1) (8 mL), DBU (20 mol%) was added. The reaction mixture was heated and stirred at 50 C for 15 min to dissolve the reactant. Then, aryl glyoxal monohydrates(1a-h, 1 mmol), 5-methylisoxazol-3-amine (6, 1 mmol, 98 mg) were added to the reaction mixture, which was stirred at the above-mentioned temperature for appropriate times as shown in Table 2. The progress of reaction was controlled by TLC using MeOH:CHCl3/1:10 as eluent. After completion of the reaction, the precipitate was filtered, washed with water and dried to give the desired products 8a-h in high yield (82-89%).

The synthetic route of 1072-67-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Aslanpanjeh, Maryam; Poursattar Marjani, Ahmad; Khalafy, Jabbar; Etivand, Nasser; Research on Chemical Intermediates; vol. 46; 1; (2020); p. 165 – 177;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1072-67-9,5-Methylisoxazol-3-amine,as a common compound, the synthetic route is as follows.

General procedure: Nitrosyl sulfuric acid solution was prepared from concentrated sulfuric acid (1.5mL) and sodium nitrite (0.14g, 2mmol) at 70C and then cooled to 5C. This solution was added dropwise, with stirring, to 3mL of (acetic acid+propionic acid) mixture (5:1v/v) containing 2.0mmol of heterocyclic amines in an ice bath. The mixture was then stirred for 1.5h at about 0-5C. After completion of diazotization procedure, the diazonium salt solution was added dropwise to the solution of 8-chloro 4-hydroxyquinoline -2-(1H)-one (0.39g, 2.0mmol) in sodium hydroxide (0.32g, 8.0mmol) and water (6.0ml). The resulting solution was vigorously stirred at about 0-4C for 2h, while the pH of the reaction mixture was maintained 10-11 by adding 2.5% sodium hydroxide solution. The progress of the reaction was followed by TLC, using (ethyl acetate+petroleum ether) mixture (5:1 v/v) as solvent. Afterwards, the pH of reaction mixture was regulated 4-5 by means of a 10% hydrochloric acid solution. At the end of the procedure, the resulting solid was filtered, washed thoroughly with cold ethanol and dried. Recrystallization from DMF-H2O ended in pure crystals of the dye. The physical and spectral data of the purified dyes are as follows.

The synthetic route of 1072-67-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yahyazadeh, Asieh; Yousefi, Hessamoddin; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 117; (2014); p. 696 – 701;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1072-67-9,5-Methylisoxazol-3-amine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 7-nitro-2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde (1), (1 mmol, 0.21 g), aniline (2a) (1 mmol, 0.09mL), dimethyl phosphite (3) (1 mmol, 0.12 mL), and Nano-TiO2/SiO2 (5 mol%) were taken in a 10 mL round-bottomed flask, stirred at 50 C for 5min. After completion of the reaction,which was indicated by TLC, the mixture was washed with ethylacetate (20 mL) to recover the catalyst by simple filtration. Thesolvent was evaporated under vacuum and the resulting crudeproduct was purified by column chromatography on silica gelusing n-hexane/ethyl acetate (1:1) as eluent to afford the pureproduct dimethyl (7-nitro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)(phenylamino)methylphosphonate (4a) (94%, Table 1).The same procedure was adopted for the preparation of allremaining title products (4b-m) by taking 2b (0.09 mL), 2c(0.13 g), 2d (0.17 g), 2e (0.10 g), 2f (0.12 g), 2g (0.14 g), 2h (0.14g), 2i (0.15 g), 2j (0.98 g), 2k (0.94 g), 2l (0.17 g) and 2m (0.15g), respectively.The Supplementary Material file contains complete characterizationdata for the new compounds and selected spectra for4a, 4b, and 4k (Figures S3-S11).

As the paragraph descriping shows that 1072-67-9 is playing an increasingly important role.

Reference£º
Article; Sravya; Grigory, Zyryanov V.; Balakrishna; Reddy, K. Madhu Kumar; Reddy, C. Suresh; Reddy, G. Mallikarjuna; Camilo; Garcia; Reddy, N. Bakthavatchala; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 193; 9; (2018); p. 562 – 567;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

1072-67-9, 5-Methylisoxazol-3-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Procedure as for 14 except using 3-amino-5-methyl-isoxazole (1.5 g, 15 mmol, 1.00 equiv) and the reaction mixture was allowed to stir at RT overnight. The precipitate obtained was washed with CH2Cl2 and then vacuum dried. Pure 25b was obtained as a white crystalline solid (766 mg, 30%). m/z (ES), found 175.0221 (C6H8-ClN2O2 [M+H]+) requires 175.0196; deltaH/ppm (400 MHz, d6-DMSO):11.25 (1H, s, NH), 6.62 (1H, s, Ar-H), 4.29 (2H, s, CH2), 2.38 (3H,s, CH3).

As the paragraph descriping shows that 1072-67-9 is playing an increasingly important role.

Reference£º
Article; Reddy, Tummala R.K.; Li, Chan; Guo, Xiaoxia; Fischer, Peter M.; Dekker, Lodewijk V.; Bioorganic and Medicinal Chemistry; vol. 22; 19; (2014); p. 5378 – 5391;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem