Day: December 6, 2022

Zhu, Yi-Ming published the artcilePalladium Catalyzed Ring Expansion Reaction of Isoxazolones with Isocyanides: Synthesis of 1,3-Oxazin-6-One Derivatives, Synthetic Route of 1076-59-1, the publication is Advanced Synthesis & Catalysis (2021), 363(3), 808-818, database is CAplus.

A palladium catalyzed ring expansion reaction of isoxazolones with isocyanides was disclosed. In the reaction, a cascade process involving ring-opening/cyclization was suggested. The reaction features high at. economy due to no elimination of CO₂ occurred. Moreover, products obtained demonstrate aggregation-induced emission properties with relatively high solid-state emission efficiencies.

Advanced Synthesis & Catalysis published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C38H74Cl2N2O4, Synthetic Route of 1076-59-1.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Xu, Rui published the artcileStudy on determination of valdecoxib as major degradation impurity in parecoxib sodium by HPLC, Category: isoxazole, the publication is Zhongguo Weisheng Jianyan Zazhi (2014), 24(19), 2785-2786, 2790, database is CAplus.

A RP-HPLC method was established for the determination of the major degradation impurity and process impurities in parecoxib sodium. The separation was performed on a Phenomenex C₁₈ column(150 mm*4.6 mm, 5μm). The mobile phase was acetonitrile-disodium hydrogen phosphate buffer solution(0.01 mol/L)(pH 3.0)(40:60, V/V). The detection was carried out with UV detector at 215 nm. The flow rate was 1.0 mL/min. The linear relationship between its major degradation impurity valdecoxib with the concentration of 0.5μg/mL∼5.0μg/mL and the response values of peak area was good, and the correlation coefficients were r=0.9997 and r=0.9992, resp. The average recovery was 100.2%±3.3%(n=9). The method was proved to be accurate, sensitive and reliable, which could be used for determination of the major degradation impurity valdecoxib in parecoxib sodium. The method was used to effectively control the quality of parecoxib.

Zhongguo Weisheng Jianyan Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C13H10O3, Category: isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Zhao, Tuan published the artcileA ZnCl₂-Catalyzed Knoevenagel Condensation/1,5-Hydride Shift/Cyclization Sequence: Synthesis of Novel Spiroisoxazol-5-one Tetrahydroquinolines, Computed Properties of 1076-59-1, the publication is ChemistrySelect (2016), 1(13), 3713-3717, database is CAplus.

A concise synthesis of novel spiroisoxazol-5-one-tetrahydroquinoline derivatives e.g., I (X = O) was developed by zinc chloride-catalyzed stereoselective Knoevenagel condensation/1,5-hydride shift/cyclization reaction of o-(dialkylamino)benzaldehydes with isoxazol-5-ones. Using this method, spiroisoxazolone-tetrahydroquinoline products were obtained in good to high yields (up to 97 % yield) with good to excellent diastereoselectivities (up to >95:5 dr). In addition, a novel 5-hydroxy-spiroisoxazoline derivative II was prepared by reduction of compound I (X = O) with lithium aluiminum hydride. Furthermore, spiroisoxazolone-tetrahydroquinoline derivative I (X = O) was transformed into spiropyrazolone I (X = NH) by reaction with hydrazine hydrate.

ChemistrySelect published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C13H18BFO2, Computed Properties of 1076-59-1.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Mei, Yi-feng published the artcileEffect of parecoxib sodium on lung cancer radical resection in patients with postoperative analgesia, HPLC of Formula: 198470-85-8, the publication is Jilin Yixue (2015), 36(8), 1510-1512, database is CAplus.

Objective: To investigate the parecoxib sodium intervention on analgesic effect in patients with lung cancer after radical operation. Methods In 52 cases of lung cancer after radical mastectomy were randomly divided into two groups, 26 cases in each. Observation group, after induction of anesthesia, was given parecoxib sodium analgesic treatment. Control group, after induction of anesthesia, was not given parecoxib sodium. Results After operation 6, 12, 18, 24, 48 h, VAS score of the observation group were lower than the control group, significant difference (P<0.05). After the operation, TNF-alpha, IL-8, IL-6 level, the observation group were lower than those in the control group, significant difference (P<0.05). Conclusion Parecoxib sodium can effectively control pain occurrence degree in lung cancer after radical operation, good analgesic effect.

Jilin Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, HPLC of Formula: 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Liu, Xiang-Wie published the artcileBase-Mediated Defluorosilylation of C(sp²)-F and C(sp³)-F Bonds, Product Details of C18H12FN, the publication is Angewandte Chemie, International Edition (2019), 58(7), 2064-2068, database is CAplus and MEDLINE.

The ability to selectively forge C-heteroatom bonds by C-F scission is typically accomplished by metal catalysts, specialized ligands and/or harsh reaction conditions. Described herein is a base-mediated defluorosilylation of unactivated C(sp²)-F and C(sp³)-F bonds that obviates the need for metal catalysts. This protocol was characterized by its simplicity, mild reaction conditions, and wide scope, even within the context of late-stage functionalization, constituting a complementary approach to existing C-Si bond-forming protocols.

Angewandte Chemie, International Edition published new progress about 57103-14-7. 57103-14-7 belongs to isoxazole, auxiliary class Fused Tricycles,Carbazoles, name is 9-(4-Fluorophenyl)-9H-carbazole, and the molecular formula is C18H12FN, Product Details of C18H12FN.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Zheng, Hao-jie published the artcileEffect of parecoxib sodium on postoperative analgesia in elderly patients after craniotomy, HPLC of Formula: 198470-85-8, the publication is Zhongguo Laonianxue Zazhi (2015), 35(8), 2132-2133, database is CAplus.

Objective: To investigate the effect of parecoxib sodium on postoperative analgesia in elderly patients after craniotomy. Methods: 123 elderly patients after craniotomy from Jan, 2011 to Jun, 2014 were selected, and were divided according to random number table into group I, group II, and group III with 40 cases in each group. Patients in group I were i.v. given parecoxib sodium 40 mg 10 min before induction of anesthesia, patients in group II were i.v. given parecoxib sodium 40 mg at the end of the surgery, and patients in group III were not given any analgesic drugs. The visual analog score (VAS), sedation score (Ramsay), β-endorphin level, postoperative adverse reaction and satisfaction of the patients were statistically collected. Results: There were significant differences in VAS between three groups at different time, VASs of group I and group II were both lower than that of group III, and that of group I was lower than that of group II (P < 0.05). There was no significant difference in Ramsay score between three groups at different time (P > 0.05). In group I, serum β-endorphin level had no significant fluctuation in preoperative time, end of operation, and postoperative time. In group II and group III, serum β-endorphin levels at end of the operation and in postoperative time were elevated compared with preoperative time, and were both higher than that of group I in the same period (P < 0.05). There was no serious adverse reaction after operation in group I, II, and III, and there was no statistical difference in the incidence of postoperative complications between three groups (P > 0.05). There were significant differences in satisfaction 24 h after surgery between three groups, the satisfactions of group I and group II were higher than that of group III, and group I was higher than group II (P < 0.05). Conclusion: Preoperative parecoxib sodium administration can improve postoperative analgesia for neurosurgical elderly patients with craniotomy, and has mild adverse reactions, and can inhibit the expression of blood β-endorphin and reduce stress response.

Zhongguo Laonianxue Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C3H5BN2O2, HPLC of Formula: 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Liu, Yan-jun published the artcileClinical efficacy of pretreatment with parecoxib sodium in postoperative analgesia of elderly patients with lumbar intervertebral disc protrusion, HPLC of Formula: 198470-85-8, the publication is Zhongguo Laonianxue Zazhi (2015), 35(3), 675-677, database is CAplus.

Objective: To investigate the clin. efficacy of pretreatment with parecoxib sodium in postoperative analgesia of elderly patients with lumbar intervertebral disk protrusion. Methods: 92 Cases of elderly patients with lumbar intervertebral disk protrusion were randomly divided into control group and parecoxib sodium pretreatment group (pretreatment group), 46 cases in each group. The control group was i.v. injected with 2 mL of physiol. saline before surgery, while the pretreatment group was i.v. injected with 40 mg of parecoxib sodium. Both groups were treated with analgesia pump after surgery. The visual analog scale (VAS) scores after 2, 4 and 6 h of surgery, times of patient-controlled i.v. analgesia (PCIA) after 4, 6 and 12 h of surgery, dosage of sufentanil in the analgesia pump after 24 h, and the number of patients with postoperative adverse reactions were recorded in both groups. Results: The VAS scores after 2, 4 and 6 h of surgery and times of PCIA after 4, 6 and 12 h of surgery in the pretreatment group were significantly lower than those in the control group (P < 0.05), and the dosage of sufentanil in the analgesia pump after 24 h in the pretreatment group was higher than that in the control group. The number of patients with nausea, vomiting, hypotension, fever and tachycardia in the pretreatment group was significantly lower than that in the control group (P < 0.05). Conclusion: Parecoxib sodium has effective postoperative analgesia effect on elderly patients with lumbar intervertebral disk protrusion, and can reduce the dosage of medicine in the analgesia pump and reduce adverse reactions.

Zhongguo Laonianxue Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, HPLC of Formula: 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Zhou, Kexu published the artcileCopper-catalyzed aerobic asymmetric cross-dehydrogenative coupling of C(sp³)-H bonds driven by visible light, Name: (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole), the publication is Green Chemistry (2020), 22(14), 4597-4603, database is CAplus.

A chiral-copper catalyst initiates the visible-light-driven oxidative CDC reaction by mol. oxygen, and governed the stereochem. In this way, a diastereo- and enantioselective synthesis of (imidazolyl)xanthenes such as I [R¹ = Me, Ph, Bn; R² = Me, cyclopropyl, Ph, etc.] via cross-dehydrogenative coupling between carbonyl compounds and xanthene derivatives was achieved. This work provided an economic and manageable approach to stereoselective C-C bond formation, and demonstrated a potential application of chiral copper catalysts in difficult asym. photochem. reactions.

Green Chemistry published new progress about 182122-10-7. 182122-10-7 belongs to isoxazole, auxiliary class BOX or PyBox,BOX or PyBox, name is (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole), and the molecular formula is C9H8BNO2, Name: (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole).

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Cui, Wenyao published the artcileThe Study of Different Approaches of Parecoxib Sodium Pretreatment on the Behavior of Rats with Neuropathic Pain, Related Products of isoxazole, the publication is Cell Biochemistry and Biophysics (2015), 72(1), 137-140, database is CAplus and MEDLINE.

Our objective is to analyze and observe the different administration routes of parecoxib sodium pretreatment on the behavioral improvement of rats with neuropathic pain to provide the preclin. data of parecoxib sodium on neuropathic pain treatment. 30 SD rats were randomly divided into five groups, including model group, sham operation group, intrathecal injection group (IT group), i.p. injection group (IP group), and perineural infiltration group (PI group). The rats in model group and three parecoxib sodium pretreatment groups received spinal nerve ligation (SNL). Heat pain test and 50 % paw mech. withdrawal threshold test (50 % PMWT) were use to assess the responses after parecoxib sodium pretreatment. 50 % PMWT results of right foot in five groups had no statistical difference (P > 0.05); 50 % PMWT results of left and right feet in three parecoxib sodium pretreatment groups were obviously higher than SNL group at different time points, which was statistically different (P < 0.05); in comparison with three pretreatment groups, the data of left foot in IT group were obviously higher than PI group and IP group, and the comparison among three groups had significant difference (P < 0.05). However, the data of right foot had no significant difference among three groups (P > 0.05). Paw thermal withdrawal latency (PTWL) results of left and right feet in five groups had no significant difference before surgery (P > 0.05); after the establishment of neuropathic model, PTWL results in five groups were significantly decreased; however, PTWL results of left and right feet at 3 days after surgery in IT group were significantly higher than the two other pretreatment groups (P < 0.05); PTWL results of left and right feet at 7 and 14 days after surgery had no significant difference. Parecoxib sodium pretreatment can effectively improve the behaviors caused by neuropathic pain, and intrathecal injection is the most effective route of administration.

Cell Biochemistry and Biophysics published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Related Products of isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Liu, Meina published the artcileSimultaneous determination of parecoxib sodium and its active metabolite valdecoxib in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study after intravenous and intramuscular administration, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2016), 220-229, database is CAplus and MEDLINE.

In this study, the authors developed and validated a new, rapid, specific and sensitive ultra-performance liquid chromatog.-tandem mass spectrometric (UPLC-MS/MS) method to simultaneously determine parecoxib sodium (PX) and its active metabolite, valdecoxib (VX), in rat plasma. Plasma samples were prepared by plasma protein precipitation combined with a liquid-liquid extraction method. The separation was carried out on a Kinetex C₁₈ column (2.1 mm × 50 mm, 2.6 μm) with a gradient elution using methanol (A) and a 2 mM ammonium acetate aqueous solution (B). The anal. was performed in less than 3 min with a flow rate of 0.2 mL/min. Ketoprofen was used as an internal standard (IS). Mass spectrometric detection was conducted with a triple quadrupole detector equipped with electrospray ionization in the neg. ion mode (ESI^–) using multiple reaction monitoring (MRM). The calibration curves were linear over the concentration ranges of 5-4000 ng/mL for PX and 5-2000 ng/mL for VX with all correlation coefficients greater than 0.998. The intra- and inter-day relative standard deviations (RSD) for both analytes were within 15% and the accuracy was within 85-115% at all quality control levels. The mean extraction recoveries for all analytes obtained from three concentrations of QC plasma samples were more than 89.0% efficient. Selectivity, matrix effect, dilution integrity and stability were also validated. The method was successfully used to investigate the pharmacokinetics of PX and VX in rat plasma after i.v. and i.m. administration of PX.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem