Day: November 21, 2022

Zhu, Daqian published the artcileDiscovery of novel N-substituted carbazoles as neuroprotective agents with potent anti-oxidative activity, Related Products of isoxazole, the publication is European Journal of Medicinal Chemistry (2013), 81-88, database is CAplus and MEDLINE.

Carbazole moiety is an important scaffold with a variety of biol. applications, for example, anti-oxidative stress. Our previous synthesized carbazoles were screened for their neuroprotective properties against two individual oxidative stresses. Some of the new carbazole derivatives were observed with modest to good neuroprotective effects on neuronal cells HT22 against cell injury induced by glutamate or homocysteic acid (HCA). Substituents introduced to the carbazole ring system play crucial roles in their biol. activities. In particular, a bulky group favors the neuroprotective activity of the compounds One of the new compounds, I, showed the best neuroprotective effects, which might result from its anti-oxidative activity with a GSH-independent mechanism. These findings might provide an alternative strategy for the development of novel carbazole derivatives for the treatment of CNS diseases such as Alzheimer’s disease.

European Journal of Medicinal Chemistry published new progress about 57103-14-7. 57103-14-7 belongs to isoxazole, auxiliary class Fused Tricycles,Carbazoles, name is 9-(4-Fluorophenyl)-9H-carbazole, and the molecular formula is C26H25N5O3, Related Products of isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Jin, Chao published the artcileCurative effect of parecoxib sodium applied at different preemptive analgesia time points on laparoscopic cholecystectomy, Related Products of isoxazole, the publication is Yaowu Liuxingbingxue Zazhi (2015), 24(1), 9-11, database is CAplus.

Objective: To discuss curative effect and security of parecoxib sodium applied on laparoscopic cholecystectomy (LC). Methods: 68 Cases of patients undergoing LC were randomly divided into observation group and control group. The patients in two groups were given LC by general anesthesia tracheal intubation, which were given remifentanil after the operation. The patients in observation group were given parecoxib sodium 40 mg iv before anesthesia induction, as well as 0.9% sodium chloride injection (NS) 2 mL iv upon the completion of operation, while the patients in control group were given 2 mL NS iv before anesthesia induction, as well as parecoxib sodium 40 mg upon the completion of operation. The visual analog scales (VAS) of patients in two groups were observed at the following time points: 1 h (T₁), 2 h (T₂), 8 h (T₃), 12 h (T₄) and 24 h (T₅) after the operation. The PCIA and adverse drug reactions in two groups were observed Results: The VAS of patients in observation group at T₁, T₂, T₃, T₄ and T₅ were better than those in control group (P < 0.05). The PCIA press times and effective press times of patients in observation group within 24 h after the operation were much less than those in control group (P < 0.05). There were no statistically significant difference between the occurrence rates of adverse drug reactions of patients in the two groups (P > 0.05). Conclusion: The application of parecoxib sodium preemptive analgesia before the anesthesia induction can receive favorable VAS effect, which can reduce the use frequency of postoperative analgesia pump, and is safe and effective.

Yaowu Liuxingbingxue Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Related Products of isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Xie, Rong published the artcileObserving the analgesic effect of parecoxib sodium in hepatic carcinoma radiofrequency ablation surgery via premedication, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Jiangsu Daxue Xuebao, Yixueban (2014), 24(2), 172-173, 176, database is CAplus.

The objective was to observe the analgesic effect of parecoxib sodium in hepatic carcinoma radiofrequency ablation surgery via premedication. The method includes enrolling 40 patients will receive hepatic carcinoma radiofrequency ablation surgery, randomly dividing them into parecoxib sodium group and control group, i.v. injection of parecoxib sodium 1 mg/kg to the patients in parecoxib sodium group 30 min before anesthesia induction, i.v. injection of physiol. saline to the control group, observing blood pressure, heart rate, blood oxygen saturation degree and breathing rate before anesthesia induction, at the point of puncture needle into skin, at the point of puncture needle into capsula fibrosa and at the end of the surgery, and recording to the VAS and untoward effect. The results show that parecoxib sodium used before hepatic carcinoma radiofrequency ablation surgery can alleviating the postoperative pain.

Jiangsu Daxue Xuebao, Yixueban published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C39H35N5O8, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Zhu, Yulin published the artcileEffect of different-time administration of parecoxib sodium on emergence agitation in patients underwent gynecological laparoscopic surgeries during general anesthesia recovery period, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Sichuan Yixue (2016), 37(1), 74-76, database is CAplus.

Objective: To investigate the effect of parecoxib sodium i.v. injection in different time on the emergence agitation (EA) in patients with gynecol. laparoscopic surgeries. Methods: Sixty patients of ASA phys. status 1 or 11, scheduled for gynecol. laparoscopic surgeries under general anesthesia were randomized into two groups, parecoxib sodium group I (group A) and parecoxib sodium group II (group B). Group A were i.v. injected parecoxib sodium 30 mg 30 min prior to the operation and Group B received the same dose but 30 min before the end of the operation. Blood pressure (BP), heart rate (HR), postoperative pain and emergence agitation were observed and recorded immediately (T₀), 5 min (T₁), 10 min (T₂) and 20 min (T₃) after the operation. Variation of blood pressure and heart rate from T₀ to T₂ from T₀ to T₂ were compared as well. Results: Higher blood pressure and heart rate were observed in both of the two groups at T₂, with statistic significance (P < 0.05). And blood pressure and heart rate change from T₀ to T₂, emergence agitation and pain score in group A had an obvious improvement compared to group B (P < 0.05). Conclusion: I.v. injection of parecoxib sodium before the operation has a significantly better efficacy on decreasing emergence agitation in gynecol. patients undergoing laparoscopic surgeries.

Sichuan Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C8H5F3O3, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Chang, Meng-Yang published the artcileNH₂OH-HCl-Mediated Umpolung α-Methylsulfonylation of α-Sulfonyl Ketones with Methylsulfoxides: Synthesis of α,β-Bis-sulfonyl Arylketones, Recommanded Product: 3-Phenylisoxazol-5(2H)-one, the publication is Organic Letters (2019), 21(6), 1832-1836, database is CAplus and MEDLINE.

In this paper, a novel and efficient route for the synthesis of α,β-bis-sulfonyl arylketones via an NH₂OH-HCl-mediated intermol. umpolung α-methylsulfonylation of α-sulfonyl ketones with methylsulfoxides is described. A plausible mechanism is proposed and discussed. Various reaction conditions for this efficient, one-pot, environmentally friendly transformation were investigated.

Organic Letters published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, Recommanded Product: 3-Phenylisoxazol-5(2H)-one.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Yan, Bing published the artcileEffect of parecoxib sodium on postoperative cognitive function in elderly patients with general anesthesia, Synthetic Route of 198470-85-8, the publication is Xiandai Zhenduan Yu Zhiliao (2016), 27(11), 2024-2026, database is CAplus.

Objective To study the effect of parecoxib sodium on postoperative cognitive function in elderly patients with general anesthesia. Methods 82 Patients for elective gastrointestinal surgery from Feb. 2014 to Feb. 2015 were randomly divided into a control group (41 cases) and an observation group (41 cases). Patients in both groups were routinely anesthetized, and after induction, 2-2.5% sevoflurane was inhaled to maintain anesthesia, rocuronium and sufentanil were injected i.v. at the same time, and propofol was continuously injected to maintain anesthesia. After surgery, the control group received i.v. injection of sodium chloride solution 2mL at 0.5h after surgery, the observation group received i.v. injection of parecoxib sodium 40mg + sodium chloride solution 2ml. Before and after the operation, the MMSE was used to evaluate the cognitive function status of the two groups, and the changes in vital signs before and after surgery were monitored, and the occurrence of adverse reactions was recorded. Results There was no significant difference in the cognitive function scores of the two groups before and 2, 5, and 7 days after the operation (P > 0.05), and the systolic blood pressure, diastolic blood pressure, heart rate and blood oxygen saturation of the two groups before and 2, 5, and 7 days after the operation were not statistically significant (P > 0.05). The incidence of adverse reactions in the observation group (12.20%) was slightly lower than that in the control group (17.07%), but the difference was not statistically significant (P > 0.05). Conclusion Parecoxib sodium has no significant influence on postoperative cognitive function in elderly patients with general anesthesia, and has good safety.

Xiandai Zhenduan Yu Zhiliao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C44H58NO5PPdS, Synthetic Route of 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Zhu, Shuai published the artcileConstruction of the tetrahydroquinoline spiro skeleton via cascade [1,5]-hydride transfer-involved C(sp³)-H functionalization “on water”, Application of 3-Phenylisoxazol-5(2H)-one, the publication is Green Chemistry (2017), 19(23), 5653-5658, database is CAplus.

The pharmaceutically important tetrahydroquinoline spiro compounds, e.g., I were efficiently constructed via cascade S_NAr/Knoevenagel condensation/[1,5]-hydride transfer/cyclization on water, featuring high atom-economy and step-economy. This water-based redox-neutral C(sp³)-H functionalization rendered a 4-step cascade reaction successful without resorting to any catalysts.

Green Chemistry published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H10O3S, Application of 3-Phenylisoxazol-5(2H)-one.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Zhang, Lei published the artcileAnalgesic effect of parecoxib sodium on anterior cruciate ligament reconstruction under arthroscopy and its effect on inflammatory factors, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Chongqing Yixue (2014), 43(33), 4532-4534, database is CAplus.

The aim is to study analgesic effect of parecoxib sodium on anterior cruciate ligament reconstruction under arthroscopy and its effect on inflammatory factors. By randomized controlled trial, 40 cases of anterior cruciate ligament reconstruction under arthroscopy were enrolled and divided into 2 groups: group A, i.v. injection of 40 mg parecoxib sodium 30 min before skin incision; group B, i.v. injection of 40 mg parecoxib sodium 30 min after skin incision. After reconstruction, both groups took PCIA pump with tramadol hydrochloride for analgesia. The VAS score and dosage of tramadol hydrochloride were compared at different time points before and after reconstruction. The serum IL-6 and IL-8 levels were also compared 30 min before skin incision(T1), 8 h after reconstruction(T2). 2 H after reconstruction, there was no statistic difference in VAS for both groups. But 8, 12 and 24 h after reconstruction, the VAS score in group B was obviously higher than that in group A. Group A took obviously less tramadol hydrochloride than group B. Result showed that the parecoxib sodium had better effect on anterior cruciate ligament reconstruction under arthroscopy and inflammatory factors.

Chongqing Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C6H5N3S, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Khutorianskyi, Andrii published the artcileDifluoromethyl Nitrile Oxide (CF₂HCNO): A Neglected Chemical Reagent, Quality Control of 1935503-24-4, the publication is European Journal of Organic Chemistry (2017), 2017(27), 3935-3940, database is CAplus.

The synthesis of CF₂H-isoxazoles I [R = CN, C(O)CH₃, CO₂Me, etc.] via [3+2]-cycloaddition of a novel chem. reagent – difluoromethyl nitrile oxide (CF₂HCNO) in-situ generated from difluoromethylacetaldehyde oximes with alkynes/enamines was reported. These products were promising cores for agrochem. A representative CHF₂-isoxazole was incorporated into the known fungicide Fluxapyroxad and the synthesized analog showed higher antifungal activity than the parent fungicide.

European Journal of Organic Chemistry published new progress about 1935503-24-4. 1935503-24-4 belongs to isoxazole, auxiliary class Difluoromethylated Building Blocks, name is 3-(Difluoromethyl)isoxazole-5-carboxylic acid, and the molecular formula is C5H3F2NO3, Quality Control of 1935503-24-4.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Ambrose, James F. published the artcileElectrochemical and spectroscopic properties of cation radicals. III. Reaction pathways of carbazolium radical ions, COA of Formula: C18H12FN, the publication is Journal of the Electrochemical Society (1975), 122(7), 876-94, database is CAplus.

The anodic oxidation pathways of seventy-six ring-substituted carbazoles are examined using electrochem. and spectral techniques. The reactivity of the substituted carbazole cation radicals is also determined The C-3, C-6, and N-9 positions are extremely reactive; if these sites are not blocked by inert substituents the cation radicals generated by electrolytic oxidation react rapidly via coupling-deprotonation. In some cases, substituents are eliminated from the C-3 and C-6 positions in the cation radicals followed by coupling to form substituted bicarbazyls. In other cases, relatively stable cation radicals are obtained and their EPR and visible absorption spectra are observed The reactivities of substituted carbazole cation radicals are greater than those of analogous di- and triphenylaminium ions due to the planarity of the carbazole aromatic rings.

Journal of the Electrochemical Society published new progress about 57103-14-7. 57103-14-7 belongs to isoxazole, auxiliary class Fused Tricycles,Carbazoles, name is 9-(4-Fluorophenyl)-9H-carbazole, and the molecular formula is C18H12FN, COA of Formula: C18H12FN.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem