Day: October 18, 2022

Ueda, Mitsuru; Oikawa, Hideaki published the artcile< Synthesis of polyamides by direct polycondensation with (1,2-benzisoxazol-3-yl) diphenyl phosphate as a new activating agent>, Application In Synthesis of 21725-69-9, the main research area is benzisoxazolyl diphenyl phosphate activating agent; polyamide synthesis activating agent; amide synthesis activating agent; carboxylic acid amine reaction.

(1,2-Benzisoxazol-3-yl) diphenyl phosphate (I) [94820-31-2] was prepared in high yield by the reaction of 1,2-benzisoxazol-3-ol  [21725-69-9] with diphenyl phosphorochloridate  [2524-64-3] in the presence of Et3N in C6H6. I was useful for the preparation of amides from carboxylic acids and amines. The direct polycondensation of several dicarboxylic acids with aromatic diamines using the activating agent I in the presence of Et3N proceeded slowly at room temperature to produce polyamides with inherent viscosities ≤1.2 dL g-1.

Journal of Polymer Science, Polymer Chemistry Edition published new progress about Polyamides Role: SPN (Synthetic Preparation), PREP (Preparation). 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Application In Synthesis of 21725-69-9.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Xu, Wei; Zhao, Jidong; Li, Xiangdong; Liu, Yuanhong published the artcile< Selective [5 + 1] and [5 + 2] Cycloaddition of Ynamides or Propargyl Esters with Benzo[d]isoxazoles via Gold Catalysis>, Application of C7H5NO2, the main research area is cycloaddition ynamide propargyl ester benzisoxazole gold catalysis; chemoselective synthesis polysubstituted benzoxazine benzoxazepine gold carbene intermediate.

Benzo[d]isoxazoles are found to act as novel nucleophiles to undergo gold-catalyzed [5 + 1] or [5 + 2] cycloaddition reactions with ynamides. The reaction provides a concise and chemoselective access to polysubstituted 2H-benzo[e][1,3]oxazines or benzo[f][1,4]oxazepines. In addition, benzo[d]isoxazoles can also react with gold-carbene intermediates derived from propargyl esters to afford [5 + 1] annulation products.

Journal of Organic Chemistry published new progress about Alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Application of C7H5NO2.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Liu, Zhen; Wang, Yanyan; Wang, Zichen; Zeng, Tian; Liu, Peng; Engle, Keary M. published the artcile< Catalytic Intermolecular Carboamination of Unactivated Alkenes via Directed Aminopalladation>, Recommanded Product: Benzo[d]isoxazol-3-ol, the main research area is palladium catalysis intermol carboamination unactivated alkene directed aminopalladation; mol modeling three component reaction directed aminopalladation.

An intermol. 1,2-carboamination of unactivated alkenes proceeding via a Pd(II)/Pd(IV) catalytic cycle has been developed. To realize this transformation, a cleavable bidentate directing group is used to control the regioselectivity of aminopalladation and stabilize the resulting organopalladium(II) intermediate, such that oxidative addition to a carbon electrophile outcompetes potential β-hydride elimination. Under the optimized reaction conditions, a broad range of nitrogen nucleophiles and carbon electrophiles are compatible coupling partners in this reaction, affording moderate to high yields. The products of this reaction can be easily converted to free γ-amino acids and γ-lactams, both of which are common structural motifs found in drug mols. and bioactive compounds Reaction kinetics and DFT calculations shed light on the mechanism of the reaction and explain empirically observed reactivity trends.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Recommanded Product: Benzo[d]isoxazol-3-ol.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem