Day: October 17, 2022

Swamy, D. K.; Deshmukh, M. V. published the artcile< Novel approach to the synthesis of 3-substituted(1,2,4)triazolo(3,4-b)1,2-benzisoxazole and their antimicrobial activity>, Category: isoxazole, the main research area is hydroxybenzisoxazole chlorination; hydrazinobenzisoxazole preparation cyclization urea; carbon sulfide cyclization hydrazinobenzisoxazole; formic acid cyclization hydrazinobenzisoxazole; triazolobenzisoxazole preparation antibacterial antifungal activity.

Hydroxybenzisoxazole was converted into chlorobenzisoxazole and then to hydrazinobenzisoxazole. New tricyclic compounds, triazolobenzisoxazole was obtained from hydrazinobenzisoxazole when treated with formic acid. Similarly 3-hydroxytriazolobenzisoxazole and 3-mercaptotriazolobenzisoxazole were prepared by the action of urea and CS2 in alkali resp. The compounds were characterized by elemental anal. and spectral data. Newly synthesized compounds were screened for their antimicrobial activities against several microbes.

Journal of Chemical and Pharmaceutical Research published new progress about Antibacterial agents. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Category: isoxazole.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Domagalina, Eugenia; Slawik, Tomasz published the artcile< Acylation of benzoxazolin-2-ones and 3-hydroxy-1,2-benzisoxazoles>, COA of Formula: C7H5NO2, the main research area is acylation bromobenzoxazolinone bromohydroxybenzisoxazole; benzoxazolinone bromo acylation; hydroxybenzisoxazole acylation; benzisoxazole hydroxy bromo acylation; CNS depressant carbethoxybenzisoxazolinone preparation; analgesic carbethoxybenzisoxazolinone preparation; anticonvulsant carbethoxybenzisoxazolinone preparation.

5-Bromo- and 5,7-dibromobenzoxazolin-2-ones were acylated with Ac2O, R1C6H4COCl (R1 = H, 2-Cl, 4-NO2), and R2O2CCl (R2 = Me, Et) to give primarily N-acylated products I (Brn = 5-Br, 5,7-Br2; R3 = Me, R1C6H4, R2O). The isomeric brominated 3-hydroxy-1,2-benzisoxazoles were predominantly O-acylated to give II (R3 the same as above). Exceptions were benzoxazole III and benzisoxazolinones IV (Brn = H, 5-Br, 5,7-Br2; R3 = R2O). IV (Brn = H, 5-Br; R3 = EtO) were the strongest central nervous system depressants and they also showed anticonvulsant activity. 5-Bromo-3-hydroxy-1,2-benzisoxazole and IV (Brn = H, R3 = EtO) had significant analgesic activity.

Polish Journal of Pharmacology and Pharmacy published new progress about Acylation. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, COA of Formula: C7H5NO2.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Kiran, B. Ravi; Vijayakumar, G. R.; Bharath, H. S.; Sivakumar, R.; Sindhu, S.; Prakash, M. Shet published the artcile< Synthesis, evaluation of analgesic and anti-inflammatory activities of substituted 1,2-benzoxazolone and 3-chloro-1,2-benzoxazole derivatives>, Reference of 21725-69-9, the main research area is benzoxazolone preparation structure activity relationship analgesic antiinflammatory activity; chloro benzoxazole preparation structure activity relationship analgesic antiinflammatory activity.

Herein method for the synthesis of substituted 1,2-benzoxazolone I [R1 = H, NO2, Br; R2 = H, Me, F; R3 = H, NO2, F] and 3-chloro-1,2-benzoxazole derivatives II [R1 = H, NO2, Br; R2 = H, Me, F; R3 = H, NO2, F] was described. A new scheme was adapted for the construction of 1,2-benzoxazole ring from salicylic acid and its derivatives which leads to the formation of series of methyl-2-hydroxy-5-bromo benzoate, Me 2-hydroxybenzoates and N,2-dihydroxybenzamides substituted title compounds Synthesized compounds were characterized by IR, 1H-NMR and Mass spectral anal. Spectral data confirmed the compounds formation. Final compounds I and II were screened for their in-vivo analgesic activity by acetic acid induced writhing method in rats and anti-inflammatory activity by carrageenan-induced paw edema model. Among the compounds screened compound I [R1, R2, R3 = H] and compound II [R1, R2 = H; R3 = NO2] showed good analgesic activity of about 45% (writhing mean 8.9) and 54% (writhing mean 7.5) inhibition resp. at 5 mg/Kg po dosage. Compounds I [R1 = NO2; R2, R3 = H] and II [R1 = NO2; R2, R3 = H] (both having inhibition edema of 66.1%) showed significant anti-inflammatory activity. Other derivatives exhibited moderate to good analgesic and anti-inflammatory activities.

International Journal of Pharmaceutical Sciences and Research published new progress about Amides, hydroxy Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Reference of 21725-69-9.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Kinstle, Thomas H.; Darlage, Larry J.; McIntosh, C. L. published the artcile< Photochemical rearrangements of 1,2-benzisoxazolinones>, Application of C7H5NO2, the main research area is benzoxazolinones via irradiation benzisoxazoles.

Irradiation of 3-hydroxy-1,2-benzisoxazole results in the formation of benzoxazolinone. This photoisomerization occurs predominantly via the keto tautomer since facile rearrangements of the N-alkyl-1,2-benzisoxazolinones occur under similar photolytic conditions. A mechanism involving a diradical species is proposed. Low temperature photolysisir measurements support this mechanism while arguing against an isocyanate or a spiro-α-lactam intermediate. Sensitization studies indicate that the rearrangement occurs predominantly from the triplet state.

Journal of Organic Chemistry published new progress about Rearrangement. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Application of C7H5NO2.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Slawik, T.; Skibinski, R.; Paw, B.; Dzialo, G. published the artcile< Reversed-phase TLC study of the lipophilicity of some 3-hydroxy-1,2-Benzisoxazoles substituted in the benzene ring>, Recommanded Product: Benzo[d]isoxazol-3-ol, the main research area is reversed phase thin layer chromatog lipophilicity hydroxy benzisoxazole derivative.

The relative lipophilicity, RM0, and specific hydrophobic surface area of eleven 3-hydroxy-1,2-benzoisoxazoles substituted in the benzene ring (two isomeric fluoro, three isomeric chloro, three isomeric bromo and dibromo derivatives, and a nitro derivative) have been studied by reversed-phase thin layer chromatog. (RP-TLC) on silica gel RP-C18 plates with methanol-water mixtures as mobile phases. Linear correlation between the volume fraction of methanol and RM values a limited range was established with high correlation coefficients (r > 0.99). Lipophilicity RM0 was compared with computed partition coefficients IAlogP, AlogPs, clogP, milogP, logPKOWIN and xlogP. The best correlation (r > 0.9) was found between RM0 and logPKOWIN anx xlogP values. Principal-components anal. (PCA) was also used to compare RM0 values with computed partition coefficients. The chromatog. behavior of 3-hydroxy-1,2-benzisoxazoles was compared with that of their bioisosteric analogs 1,2-benzisothiazolonoles. Exptl. RM0 values for both groups of compounds were in accordance with the equation RM0 = aRM0 + b (r > 0.9).

Acta Chromatographica published new progress about Lipophilicity. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Recommanded Product: Benzo[d]isoxazol-3-ol.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem