Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.206055-91-6,(3-(4-Bromophenyl)isoxazol-5-yl)methanol,as a common compound, the synthetic route is as follows.

General procedure: In 100 mL three-necked flask, (3-substituted phenylisoxazol-5-yl)methanols (3a-l) (5 mmol) was poured into a stirred mixture of sodium hydride (15 mmol) and anhydrous THF (10 mL) previously cooled in glacial bath. Propargyl bromide (6 mmol, 0.47 mL) was added, and the mixture was stirred at room temperature (20-25 C) until the reaction was over by TLC monitoring. The slurry was filtrated by sabouraud funnel. Filtrate was evaporated under a vacuum to provide the crude product which was purified by column chromatography (silica gel, 200-300 mesh) using petroleum ether/ethyl acetate (phir = 4:1) to furnish the desired product 4a-l in 68-96% yield.

206055-91-6, As the paragraph descriping shows that 206055-91-6 is playing an increasingly important role.

Reference£º
Article; Zhang, Da-wei; Zhang, Yu-min; Li, Jing; Zhao, Tian-qi; Gu, Qiang; Lin, Feng; Ultrasonics Sonochemistry; vol. 36; (2017); p. 343 – 353;,
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Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228689-61-9,Methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate,as a common compound, the synthetic route is as follows.

Step 4: 5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid 5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid methyl ester (39 mmol) in MeOH (50 mL) and H2O (10 mL) was treated with lithium hydroxide (2 g, 48 mmol) and the reaction was stirred at 60 C. for 1 hour. The mixture was acidified, and standard workup provided the title compound.

1228689-61-9, As the paragraph descriping shows that 1228689-61-9 is playing an increasingly important role.

Reference£º
Patent; Amira Phamaceuticals, Inc.; US2011/82181; (2011); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

850832-54-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.850832-54-1,Methyl 4-bromo-5-methylisoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.

An aqueous sodium hydroxide solution (4N, 20.5 ml, 81. 8 mmol) was added to a solution of methyl 4-bromo-5-methyl- isoxazole-3-carboxylate (15.0 g, 68.2 mmol) in methanol (150 ml) under ice-cooling, and the mixture was stirred at room temperature for 2 hours. Hydrochloric acid (6N, 13.6 ml, 81. 8 mmol) was added and the mixture was concentrated under reduced pressure. The residue was dissolved in ethyl acetate, dried over sodium sulfate, filtered through a celite pad and concentrated under reduced pressure. The residue was triturated with diisopropyl ether to give 4- bromo-5-methylisoxazole-3-carboxylic acid (12.1 g, 86%) as a solid. MS: 160/162 [M-C02-H]-, ESI (MeOH)

The synthetic route of 850832-54-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TANABE SEIYAKU CO., LTD.; WO2005/37271; (2005); A2;,
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Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.946426-89-7,5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazole-4-methanol,as a common compound, the synthetic route is as follows.

The intermediate compound (12.2 g, 43.02 mmol) prepared in the above step 4 was dissolved in dichloromethane (158 ml) and then cooled to 0 C.Triphenylphosphite (TPP, 16.9 g, 64.53 mmol) and tetrabromomethane (21.4 g, 64.53 mmol) were slowly added at the same temperature and stirred at room temperature for 4 hours.The reaction mixture was concentrated and purified by silica gel chromatography to obtain the title compound (13.44 g, 90%)., 946426-89-7

946426-89-7 5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazole-4-methanol 45790382, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Ildong Pharmaceutical Co., Ltd.; Kang Jae-hun; Lee Hong-seop; Lee Yun-seok; Jeong Jin-a; Kwon Seong-uk; Kim Gyeong-seon; Song Dong-geun; Choi Ji-hye; Hwang Hye-min; (43 pag.)KR2018/115126; (2018); A;,
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Isoxazole | C3H3NO – PubChem

1136-45-4, 5-Methyl-3-phenylisoxazole-4-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of YD-014 (320 mg, 1.58 mmol) in anhydrous dichloromethane (10 mL) was added in sequence diisopropylethylamine (DIEA, 305 mg, 2.36 mmol), YD-05 (380 mg, 1.58 mmol) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDCI, 1.2 g, 6.30 mmol). The resulting mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with dichloromethane, and washed in sequence with aqueous sodium hydroxide (2 M), water and saturated brine. The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was purified by column chromatography eluting with petroleum ether in ethyl acetate (3:1) to give YD-01 (290 mg, 43% yield) as a light yellow solid.1H-NMR (400 MHz, DMSO-d6) delta 8.23 (d, 111, J=2.6 Hz, 1′-H), 8.15 (dd, 1H, J=9, 2.6 Hz, 2′-H), 7.63-7.60 (m, 2H, 1-H, 5-H), 7.55-7.52 (m, 3H, 2-H, 3-H, 4-H), 7.20 (d, 1H, J=9 Hz, 3′-H), 3.81 (br s, 2H, CH2), 3.39 (br s, 21-1, CH2), 3.20 (br s, 2H, CH2), 2.85 (br s, 2H, CH2), 2.50 (s, 3H, -CH3);13C-NMR (100 MHz, DMSO-d6) delta 168.8, 161.2, 159.6, 153.9, 141.9, 130.2, 129.1, 127.9, 127.3, 126.3, 125.9, 123.7, 120.6, 110.7, 50.1, 49.7, 46.3, 41.3, 11.4; LRMS (API-ES): 427 (M++H)., 1136-45-4

1136-45-4 5-Methyl-3-phenylisoxazole-4-carboxylic acid 14343, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; The University of Hong Kong; US2011/212975; (2011); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

123320-44-5, (3-(Benzyloxy)isoxazol-5-yl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of cyanic bromide (334 mg, 3.15 mmol, 1.05 eq) and (2547) triphenylphosphine (787 mg, 3.00 mmol, 1.00 eq) in dichloromethane (10 mL) was added a solution of (3-benzyl oxyisoxazol-5-yl)methanol (616 mg, 3.00 mmol, 1.00 eq) in (2548) dichloromethane (10mL). The mixture was stirred at 15 C for 1 hour, then 2,3,4,6,7,8,9,10- octahydropyrimido [1,2-a]azepine (480 mg, 3.15 mmol, 1.05 eq) was added at 0 C. The resulting mixture was stirred at 0~15 C for another 14 hr. The solvent was concentrated in vacuum. The residue was further purified by silica gel column chromatography (Petroleum ether: Ethyl acetate = 5:1 to 4:1) to afford 2-(3-benzyloxyisoxazol-5-yl)acetonitrile (320 mg, 1.49 mmol, 50% yield) as a colorless oil. LC/MS (ESI) m/z: 215.0 [M+1] +; 1H-NMR (400MHz, CDCl3) d 7.48 – 7.41 (m, 5H), 6.06 (s, 1H), 5.30 (s, 2H), 3.82 (s, 2H)., 123320-44-5

As the paragraph descriping shows that 123320-44-5 is playing an increasingly important role.

Reference£º
Patent; ARVINAS OPERATIONS, INC.; YALE UNIVERSITY; CREW, Andrew P.; HORNBERGER, Keith R.; WANG, Jing; CREWS, Craig M.; JAIME-FIGUEROA, Saul; DONG, Hanqing; QIAN, Yimin; ZIMMERMAN, Kurt; (1451 pag.)WO2020/51564; (2020); A1;,
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Isoxazole | C3H3NO – PubChem

946426-89-7, 5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazole-4-methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Compound 23e (800 mg, 2.05 mmol) and Compound INT-003 (630 mg, 2.22 mmol) in toluene (12 mL) was added cesium carbonate (1.3 g, 3.98 mmol), RockPhos (94 mg, 0.19 mmol) and [PdCl(allyl)]2 (15 mg, 0.04 mmol). The resulting solution was stirred for 2 h at 80C under N2atmosphere. The resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1 :2). The collected fractions were combined and concentrated under vacuum. This resulted in 0.8 g (66%) of the title compound as a solid. LC-MS (ES, m/z): [M+H]+= 595.3, 946426-89-7

As the paragraph descriping shows that 946426-89-7 is playing an increasingly important role.

Reference£º
Patent; HEPAGENE THERAPEUTICS, INC.; XU, Xiaodong; (106 pag.)WO2018/75207; (2018); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

1136-45-4, 5-Methyl-3-phenylisoxazole-4-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 8 5-Methyl-3-phenyl-isoxazole-4-carbonyl Chloride. 5-Methyl-3-phenyl-isoxazole-4-carboxylic acid (0.54 g, 2.56 mmol) was treated with SOCl2 (2 mL) at 70 C. for 1 hr. Concentration in vacuum gave a yellow oil which was used without purification.

1136-45-4, 1136-45-4 5-Methyl-3-phenylisoxazole-4-carboxylic acid 14343, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Green, Jeremy; Bemis, Guy; Grillot, Anne-Laure; Ledeboer, Mark; Salituro, Francesco G.; Harrington, Edmund; Gao, Huai; Baker, Christopher; Cao, Jingrong; Hale, Michael; US2003/149051; (2003); A1;,
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Isoxazole | C3H3NO – PubChem

954230-39-8,954230-39-8, Ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a suspension of LiAlH4 (75.9 mg, 2.0 mmol) in THF (2 mL) was added at 0-10 C. within 15 minutes a solution of 3-(4-Fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester (0.50 g, 2.0 mmol) in THF (3 mL) and the resulting solution was allowed to warm to room temperature and subsequently stirred at this temperature for at least one hour. Water (15 mL) was added dropwise and the resulting suspension was then filtered and the filter cake washed with ethyl acetate (15 mL). From the biphasic filtrate the layers were separated and the organic layer was washed with water (1¡Á15 mL). Both combined aqueous layers were back extracted with ethyl acetate (2¡Á15 mL). The combined organic layers were dried over Na2SO4 and subsequently concentrated to dryness (45 C./25 mbar) to afford 0.375 g (90%) of the title compound as a slightly yellow solid with a purity of 100% (by HPLC).

954230-39-8 Ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate 22309061, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Hoffmann-La Roche Inc.; Dott, Pascal; Hanlon, Steven Paul; Hildbrand, Stefan; Iding, Hans; Thomas, Andrew; Waldmeier, Pius; US2013/102778; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

7063-99-2, Ethyl 5-phenylisoxazole-3-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,7063-99-2

General procedure: To a stirred solution of ester 12-20 (1 equiv) in EtOH (95%), was added sodium hydroxide in pellets (10 equiv). The mixture was then stirred at room temperature for 24 h. EtOH was removed under reduced pressure and the residue was acidified (1N HCl, pH 2) and extracted with EtOAc. The organic extracts were washed with water and brine, dried over MgSO4 and concentrated under reduced pressure to afford essentially pure carboxylic acid 21-29.

The synthetic route of 7063-99-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Andrzejak, Virginie; Muccioli, Giulio G.; Body-Malapel, Mathilde; El Bakali, Jamal; Djouina, Madjid; Renault, Nicolas; Chavatte, Philippe; Desreumaux, Pierre; Lambert, Didier M.; Millet, Regis; Bioorganic and Medicinal Chemistry; vol. 19; 12; (2011); p. 3777 – 3786;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem