Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.

62348-13-4, General procedure: A solution of the corresponding acyl chloride 1-10 (9.18 mmol) in chloroform (25 mL) was slowly added dropwise to a stirred solution of compounds a-c (4.59 mmol) in dry chloroform (40 mL) and pyridine (5 mL). The mixture was stirred for 48 h at room temperature. Solvents were removed under vacuum by rotatory evaporation and the residue was treated with water (100 mL) and purified.

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Article; Ibanez, Elena; Plano, Daniel; Font, Maria; Calvo, Alfonso; Prior, Celia; Palop, Juan Antonio; Sanmartin, Carmen; European Journal of Medicinal Chemistry; vol. 46; 1; (2011); p. 265 – 274;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

2510-36-3, 3,5-Dimethylisoxasole-4-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3,5-dimethylisoxazole-4-carboxylic acid (1000 mg, 7.09 mmol) was heated to 80 C in SOCl2 (5.17 ml, 70.8 mmol) for 30 min. The remaining solvent was evaporated and the crude material dissolved in DCM (15 ml). After cooling to 0 C Nu,Omicron-dimethylhydroxlamine hydrochloride ( 1036.8 mg, 10.6 mmol) was added and, dropwise, pyridine (0.86 ml, 10.6 mmol) and the mixture was stirred over night at rt. 1M HC1 and DCM were added and the phases were separated. After flash chromatographic separation N-methoxy-N,3,5-trimethylisoxazole-4-carboxamide (1300 mg, 7.06 mmol) was obtained.

2510-36-3, 2510-36-3 3,5-Dimethylisoxasole-4-carboxylic acid 75636, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; KARO BIO AB; WENNERSTAL, Mattias; LOeFSTEDT, Joakim; WU, Xiongyu; KRUeGER, Lars; HAGBERG, Lars; WO2011/42477; (2011); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

21169-71-1, Isoxazole-5-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Compounds were synthesized in solution phase using Boc-protected amino acids on 100-200mg scale. Firstly, the amino acid (1.2-1.5equiv) was activated with HBTU (1.5equiv) and DIPEA (1.5equiv) as 0.2-0.5M solution in DMF for 10min. Then the solution was added to an amino group bearing C-terminal moiety (R1R2NH) and the mixture was stirred for a minimum of 1h at room temperature. The reaction mixture was diluted with EtOAc and washed with saturated NaHCO3 (2¡Á). The organic extracts were dried over MgSO4, filtered and evaporated in vacuo. The crude product was then treated with 20% TFA in DCM and stirred for 1-2h to remove the Boc group. TFA was removed by evaporating the reaction mixture under a stream of N2. The residue was dissolved in DCM and washed with saturated NaHCO3 (2¡Á). DCM phase was dried with MgSO4, filtered and evaporated in vacuo. Subsequent N-Boc-amino acids and amines were sequentially coupled under the same conditions. Each coupling reaction was monitored by ESMS, with most reactions going to completion overnight. All final compounds were purified on rpHPLC (97% by analytical HPLC) and fully characterized by NMR and HRMS (yields between 30% and 40%).

21169-71-1, 21169-71-1 Isoxazole-5-carboxylic acid 2060599, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Article; Yau, Mei-Kwan; Liu, Ligong; Lim, Junxian; Lohman, Rink-Jan; Cotterell, Adam J.; Suen, Jacky Y.; Vesey, David A.; Reid, Robert C.; Fairlie, David P.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 3; (2016); p. 986 – 991;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

35166-33-7, 3-Hydroxymethyl-5-methylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2 3-(chIoromethyl)-5-methylisoxazole To a solution of (5-methylisoxazol-3-yl)methanol (370 mg, 3.27 mmol) in DCM (5 mL) was added thionyl chloride (5 mL) dropwise. The resulting mixture was stirred at room temperature for 16 h. The mixture was concentrated to give 3-(chloromethyl)-5-methylisoxazole (350 mg, crude) as brown oil, which was used without purification. LCMS retention time 0.768 min; LCMS MH+ 132.

35166-33-7, The synthetic route of 35166-33-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HYDRA BIOSCIENCES, INC.; CHENARD, Bertrand; GALLASCHUN, Randall; WO2014/143799; (2014); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2510-36-3,3,5-Dimethylisoxasole-4-carboxylic acid,as a common compound, the synthetic route is as follows.,2510-36-3

Preparation 34 N-methoxy-N,3,5-trimethylisoxazole-4-carboxamide A/-methoxy-A/,3,5-trimethylisoxazole-4-carboxamide A solution of 3,5-dimethylisoxazole-4-carboxylic acid (15 g, 106 mmol), N,0- dimethylhydroxylamine hydrochloride (11.40 g, 1 17 mmol), HATU (44.5 g, 117 mmol) and Hunig’s Base (46.4 ml, 266 mmol) in DCM (304 ml) was stirred at rt for 2 days. Water was added and the aqueous layer was extracted with DCM (x3). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, and filtered, and the filtrate was evaporated in vacuo to give the crude product. The crude product was purified by silica gel chromatography eluting with 0-40% EtOAc/Hexane to give N- methoxy-N,3,5-trimethylisoxazole-4-carboxamide (19 g) as a colorless oil. ‘H NMR (500MHz, CHLOROFORM-d) delta 3.53 (s, 3H), 3.36 (s, 3H), 2.48 (s, 3H), 2.34 (s, 3H).

As the paragraph descriping shows that 2510-36-3 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WU, Yong-Jin; GUERNON, Jason M.; WO2014/98831; (2014); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

2510-36-3, 3,5-Dimethylisoxasole-4-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1.1; N-[(3,5-dimethylisoxazol-4-yl)carbonyl]-3-(5-{3-[6-(methylamino)pyridin-2-yl]propyl}thiophen-2-yl)-L-alanine; To a solution of methyl 3-(5-{3-[6-(methylamino)pyridin-2-yl]propyl}-2-thienyl)-L-alaninate (190 mg, 0.57 mmol) in DMF (1.5 ml) were added TBTU (259 mg, 0.68 mmol) and a solution of 3,5-dimethylisoxazole-4-carboxylic acid (80 mg, 0.57 mmol) in DMF (6 ml). The reaction mixture was allowed to stir at room temperature for 48 hours. NaOH 6N (15 drops) was then added. After 3 hours at room temperature, the crude mixture was filtered and purified by C18 reverse phase chromatography (basic conditions) to afford the title compound as a pale yellow solid (190 mg, 76%).1H NMR Spectrum (DMSO-d6) 1.87-1.96 (m, 2H), 2.18 (s, 3H), 2.39 (s, 3H), 2.53 (t, 2H), 2.70-2.77 (m, 5H), 3.16 (dd, 1H), 3.33 (dd, 1H), 4.51 (ddd, 1H), 6.23 (d, 1H), 6.30 (d, 1H), 6.33 (bs, 1H), 6.65 (d, 1H), 6.72 (d, 1H), 7.27 (dd, 1H), 8.28 (d, 1H)Mass Spectrum [M+H]+=443

2510-36-3, 2510-36-3 3,5-Dimethylisoxasole-4-carboxylic acid 75636, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; US2008/255183; (2008); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21169-71-1,Isoxazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.

21169-71-1, A solution of 5-isoxazolecarboxylic acid (500 mg, 4.42 mmol, commercially available from e.g. Sigma-Aldrich, Maybridge or Apollo) in dry dichloromethane (DCM) (14.700 ml) was stirred at room temperature under an atmosphere of argon. EDC (1017 mg, 5.31 mmol) and HOBt (339 mg, 2.21 1 mmol) were added to the solution and stirring was continued at room temperature for 1/2 hour. After this time, 1 ,1-dimethylethyl hydrazinecarboxylate (701 mg, 5.31 mmol) was added to the reaction mixture and stirring was continued for a further 18 hours at room temperature (overnight). The solution was diluted with DCM (approx 30 ml) and washed with water (2 x 20 ml). The organics were dried over MgSO4, filtered and concentrated under reduced pressure to give a colourless oil. The oil was chromatographed [Sitheta2, EtOAc/Hexane 0-100%] to give a colourless, thick oil in 321 mg. The oil was used directly in the next step. LCMS [M-H] 226.22 and [M+H- BOC]+ 128.07 (at) 0.60 min (2 min run).

21169-71-1 Isoxazole-5-carboxylic acid 2060599, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; SIME, Mairi; STEADMAN, Jon Graham Anthony; THEWLIS, Rachel Elizabeth Anne; TRANI, Giancarlo; WALTER, Daryl Simon; WO2010/125102; (2010); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19788-36-4,(3,5-Dimethyl-4-isoxazolyl)methanol,as a common compound, the synthetic route is as follows.

To a solution of (3,5-dimethylisoxazol-4-yl)methanol (1.00 g, 7.86 mmol) in CH2CI2 (20 mL) at 0 C was added Dess-Martin periodinane (4.17 g, 9.83 mmol) very slowly over 10 min and the reaction mixture was warmed to rt. The reaction mixture was stirred at rt for 60 min and then filtered through Celite and washed through with CH2C12. The organic layer was dried over Na2S04, concentrated, and purified by column chromatography (15% EtOAc/hexanes) to provide the title compound (0.450 g, 46%). ? NMR (400 MHz, DMSO-d6) delta ppm 9.92 (s, 1H), 2.68 (s, 3H), 2.37 (s, 3H)., 19788-36-4

As the paragraph descriping shows that 19788-36-4 is playing an increasingly important role.

Reference£º
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard; WO2013/19682; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

19788-37-5, 4-(Chloromethyl)-3,5-dimethylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Chloromethyl-3,5-dimethyl-isoxazole (1.5 eq. ) was directly added to a solution of 7- furan-2-yl-2-piperazin-1-yl-pyrazolo[1,5-a][1,3,5]triazin-4-ylamine (0.14 mmol) and Et3N (0.3 mmol) in 3 mL of CH3CN. The resulting reaction mixture was stirred at room temp for 18 hours. It was then concentrated and purified by preparative HPLC using a mixture of aqueous CH3CN that has been buffered with 0.1% TFA. 1H NMR (DMSO-d6) delta 7.60 (d, J = 1.0 Hz, 1 H), 7.28 (br s, 2 H), 7.22 (d, J = 3.6 Hz, 1 H), 6.68 (dd, J = 3.6 Hz, 1.0 Hz, 1 H), 6.2 (s, 1 H) 3.8 (br s, 2 H), 2.2-3.2 (m, 8H), 1.6 (br s, 6H). MS: m/z: 395 [M + H] +., 19788-37-5

The synthetic route of 19788-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BIOGEN IDEC MA INC.; WO2004/92170; (2004); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-13-7,4-Nitroisoxazole,as a common compound, the synthetic route is as follows.

4- Nitroisoxazole (may be prepared as described in Description 94; 850 mg, 7.45 mmol) was added to a solution of ammonium chloride (9169 mg, 171 mmol) in water (60 ml). The resultant suspension was cooled to 0C, and zinc (4142 mg, 63.3 mmol) was added in portions whilst keeping the temperature below 5C. After the addition, the mixture was stirred at 0-5C for 2 hours. The reaction mixture was then filtered, and the filtrate was extracted with ethyl acetate (100 ml x 4). The organic phase was washed by water (100 ml x 2), dried over anhydrous MgS04, and concentrated to yield the title compound as a brown oil, 535 mg., 1121-13-7

The synthetic route of 1121-13-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; NICHOLS, Paula Louise; EATHERTON, Andrew John; BAMBOROUGH, Paul; JANDU, Karamjit Singh; PHILPS, Oliver James; ANDREOTTI, Daniele; WO2011/38572; (2011); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem