Tag: M.W:0-100

1072-67-9, 5-Methylisoxazol-3-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Sodium nitrite (0.14 g, 2.0 mmol) was added portion-wise to 3.0 mL of sulfuric acid at 15 C and heated to 60 C with stirring for 20 min. The solution was cooled to below 5 C and a mixture of acetic and propionic acids (5:1, 3 mL) were added at below 25 C. The finely heterocyclic amine derivatives (2.0 mmol) were slowly added, within 25 min below 5 C, and the whole mixture was stirred at 0-5 C for 2 h. After completion of diazotization procedure, the diazonium salt solution was added drop-wise to the solution of 6-amino-1,3-dimethyluracil (2.0 mmol, 0.31 g) in sodium hydroxide (4.0 mmol, 0.16 g) and water (5.0 mL). The resulting solution was vigorously stirred at 0-5 C for 1 h and the progress of the reaction was followed by TLC, using an ethyl acetate-petroleum ether mixture (4:1 v/v) as developing solvent. After neutralizing the residual HCl and filtration, the product was crystallized from DMF. The physical and spectral data of the purified dyes are as follows.

1072-67-9, The synthetic route of 1072-67-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yousefi, Hessamoddin; Yahyazadeh, Asieh; Yazdanbakhsh, Mohammad Reza; Rassa, Mehdi; Moradi-E-Rufchahi, Enayat O’Llah; Journal of Molecular Structure; vol. 1015; (2012); p. 27 – 32;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14678-02-5,5-Amino-3-methylisoxazole,as a common compound, the synthetic route is as follows.

a) 2-Bromo-N-(3-methyl-isoxazol-5-yl)-acetamide 3-Methyl-isoxazol-5-ylamine (2.9 g) and potassium carbonate (9.8 g) were suspended in dichloromethane (100 mL) at room temperature and 2-bromoacetyl bromide (6 g) was added dropwise. The mixture was allowed to stir overnight. Water (0.3 mL) was added together with a further quantity of potassium carbonate (3 g) and the reaction mixture stirred for a further 30 minutes. The reaction mixture was poured into water (100 mL) and extracted with dichloromethane (2*50 mL). The combined organic extracts were dried over magnesium sulfate and then evaporated in vacuo. The crude product was purifed by column chromatography on silica eluting with ethyl acetate/isohexane (50:50) to give sub-titled compound (4.8 g). 1H NMR (300 MHz, CDCl3) delta 11.97 (s, 1H), 6.16 (s, 1H), 4.09 (s, 2H), 2.19 (s, 3H)., 14678-02-5

14678-02-5 5-Amino-3-methylisoxazole 84590, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Bull, Richard James; Skidmore, Elizabeth Anne; Ford, Rhonan Lee; Mather, Andrew Nigel; Mete, Antonio; US2011/172237; (2011); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1750-42-1,Isoxazol-3-amine,as a common compound, the synthetic route is as follows.

EXAMPLE 305 Synthesis of (f?)-3-chloro-/V-(isoxazol-3-yl)-4-((1-(1-phenylethyl)piperidin-4- yl)oxy)benzenesulfonamide formate Step 1. Preparation of 3-chloro-4-fluoro-/V-(isoxazol-3-yl)benzenesulfonamide To a mixture of isoxazol-3-amine (0.500 g, 5.95 mmol), 4- dimethylaminopyridine (0.0727 g, 0.595 mmol) and pyridine (0.941 g, 1 1.9 mmol) in dichloromethane (2 mL) was added a solution of 3-chloro-4-fluoro-benzene-1-sulfonyl chloride (1.64 g, 7.14 mmol) in dichloromethane (1 mL) at 0 C. The mixture was stirred at ambient temperature for 12 h and was then diluted with water (20 mL) and extracted with dichloromethane (2 chi 30 mL). The combined organic extracts were washed with water (20 mL), dried over anhydrous sodium sulfate, and filtered. Concentration of the filtrate in vacuo and purification of the residue by preparative reverse phase HPLC, using acetonitrile in water containing 0.1 % of formic acid as eluent, afforded the title compound as a colorless solid (0.250 g, 15% yield): H NMR (400 MHz, CDCIs) 8.31 (d, J = 1.8 Hz, 1 H), 7.92-7.90 (m, 1 H), 7.76-7.74 (m, 1 H), 7.22 (t, J = 8.5 Hz, 1 H), 6.62 (s, 1 H), NH not observed; MS (ES+) m/z 276.9 (M + 1)., 1750-42-1

As the paragraph descriping shows that 1750-42-1 is playing an increasingly important role.

Reference£º
Patent; XENON PHARMACEUTICALS INC.; ANDREZ, Jean-Christophe; BURFORD, Kristen, Nicole; CHOWDHURY, Sultan; COHEN, Charles, Jay; DEHNHARDT, Christoph, Martin; DEVITA, Robert, Joseph; EMPFIELD, James, Roy; FOCKEN, Thilo; GRIMWOOD, Michael, Edward; HASAN, Syed, Abid; JOHNSON, James, Philip, Jr.; ZENOVA, Alla, Yurevna; (493 pag.)WO2017/201468; (2017); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

14678-02-5, 5-Amino-3-methylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3-methyl-1,2-oxazol-5-amine (583 mg, 5.94 mmol) and diisopropylethylamine (1.04 g, 8.08 mmol) in dichloromethane (12 mL), was added dropwise a solution of ditrichloromethyl carbonate (601 mg, 2.03 mmol) in dichloromethane (6 mL). The resulting mixture was stirred at room temperature for 20 min. A solution of 32-3 (500 mg, 1.49 mmol) in dichloromethane (2 mL) and triethylamine (902 mg, 8.91 mmol) was added and the reaction mixture was stirred at room temperature for another 5 h. Water and dichloromethane were added. The organic phase was separated, washed with brine, dried over anhydrous sodium sulfate, and concentrated under vacuum. The residue was purified by silica gel column with ethyl acetate/petroleum ether (1/20) as the eluent to afford the desired product (580 mg, 85% yield)., 14678-02-5

As the paragraph descriping shows that 14678-02-5 is playing an increasingly important role.

Reference£º
Patent; INVENTISBIO INC.; DAI, Xing; WANG, Yaolin; (187 pag.)WO2017/139414; (2017); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.354795-62-3,3-Methylisoxazol-4-amine,as a common compound, the synthetic route is as follows.

Example 165-Bromo-2-{[(4-fluorophenyl)methyl]oxy}- V-(3-methyl-4-isoxazolyl)-4-(4- morpholinylmethyl)benzamide (E16)To a solution of 5-bromo-2-{[(4-fluorophenyl)methyl]oxy}-4-(4-morpholinylmethyl)benzoic acid (may be prepared as described in Description 20; 150 mg, 0.35 mmol) in N,N- dimethylformamide (4 ml) was added 3-methyl-4-isoxazolamine (41.6 mg, 0.42 mmol), diisopropylethylamine (0.12 ml, 0.71 mmol), 1 -hydroxy- 7-azabenzotriazole (57.7 mg, 0.42 mmol) and EDC (102 mg, 0.53 mmol). The mixture was stirred for 18 hours, then the solvent removed in vacuo to give a residue. The residue was purified by column chromatography (10% 7M NH3 in methanol/dichloromethane) to yield the title compound as a solid. 178 mg. MS (electrospray): m/z, [M+H]+ = 504/506

354795-62-3, 354795-62-3 3-Methylisoxazol-4-amine 13804284, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; ANDREOTTI, Daniele; DAI, Xuedong; EATHERTON, Andrew John; JANDU, Karamjit Singh; LIU, Qian; PHILPS, Oliver James; WO2012/28629; (2012); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14678-02-5,5-Amino-3-methylisoxazole,as a common compound, the synthetic route is as follows.

Prepared by following a methodology reported by M. Ohkubo et al. in Chem Pharm Bull. 1995, 43 (9), 1497-1504.To a solution of 5-amino-3-methylisoxazole (0.165 g, 1.67 mmol) in anhydrous toluene (6.5 ml) and anhydrous pyridine (0.18 ml, 2.0 mmol) cooled in an ice/water bath (T=10 C.) was slowly added bromoacetyl bromide (0.402 g, 2.0 mmol). The reaction mixture was stirred for 1.5 h under argon, then poured into water (20 ml), and extracted with ethyl acetate (2¡Á40 ml). The combined organics were washed with water (30 ml), brine (30 ml), dried (Na2SO4), and concentrated in vacuo. The residue was triturated with diethyl ether, the precipitate was removed by filtration, and the filtrate was concentrated in vacuo to afford the title compound as a white solid (0.200 g, 55%); 1H-NMR (500 MHz, DMSO-d6) 2.18 (s, 3H, CH3), 4.08 (s, 2H, CH2Br), 6.15 (s, 1H, isoxazole C-H), 11.94 (s, 1H, CONH);LC (Method B)-MS (ESI, m/z): Rt=2.92 min-219, 221 [(M+H)+, Br isotopic pattern]., 14678-02-5

As the paragraph descriping shows that 14678-02-5 is playing an increasingly important role.

Reference£º
Patent; THE INSTITUTE OF CANCER RESEARCH; US2009/247507; (2009); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14678-02-5,5-Amino-3-methylisoxazole,as a common compound, the synthetic route is as follows.

General procedure: A solution of 2-(chloroseleno)benzoyl chloride (1 mmol) in dryether (10 mL) was added dropwise over 30 min to a stirred solution ofthe appropriate amine (1.2 mmol) and triethylamine (3.5 mmol) in dryDCM (10 mL) at 0 C. The reaction mixture was stirred at room temperatureovernight. The solvent was removed under reduced pressureand the residue was washed with water (20 mL), and extracted withDCM (3¡Á10 mL). The combined organic extracts were dried over anhydrousMgSO4, the solvent removed was under reduced pressure, andthe crude product was purified by flash column chromatography onsilica gel (eluents: 10-50% ethyl acetate in petroleum gradient) [31].All EB analogues except 4c and 4e have been reported., 14678-02-5

The synthetic route of 14678-02-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chen, Cheng; Yang, Kewu; Bioorganic Chemistry; vol. 93; (2019);,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5765-44-6,5-Methylisoxazole,as a common compound, the synthetic route is as follows.

5765-44-6, Example 11A Sodium 1-cyanoprop-1-en-2-olate Sodium (7.69 g, 335 mmol) is introduced in portions into 350 ml of anhydrous methanol. After the reaction mixture has been cooled to 25 C., 5-methylisoxazole (27.8 g, 335 mmol) is slowly added in portions (exothermic reaction). After the addition is complete, the mixture is stirred at RT for 4 h and then concentrated. The residue is washed with a little diethyl ether, filtered off with suction and dried under oil pump vacuum. 32.0 g (91% of theory) of the title compound are obtained. 1H-NMR (400 MHz, DMSO-d6): delta=3.18 (s, 1H), 1.51 (s, 3H).

5765-44-6 5-Methylisoxazole 79833, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; US2010/305052; (2010); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

14678-02-5, 5-Amino-3-methylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-Methylisoxazol-5-amine (2.9 g) and potassium carbonate (9.8 g) were suspended in dichloromethane (100 mL) at room temperature 2-bromoacetyl bromide (6 g) was added dropwise. The mixture was allowed to stir overnight. Water (0.3 mL) was added together with a further quantity of potassium carbonate (3 g) and the reaction stirred for a further 30 minutes. The reaction mixture was poured into water (100 mL) and extracted with dichloromethane (2 x 50 mL). The combined organic extracts were dried over Magnesium Sulfate and then evaporated in vacuo. The crude product was purifed by column chromatography on silica eluting with ethyl actetate / isohsxane (50:50) to give sub-titled compound (4.8 g).1H NMR (299.946 MHz, CDCl3) delta 11.97 (s, IH)5 6.16 (s, IH), 4.09 (s, 2H), 2.19 (s, 3H).

14678-02-5, The synthetic route of 14678-02-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/59245; (2008); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

1750-42-1, Isoxazol-3-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 10: 3-Amino-4-chloroisooxazole.; To a 50 ml_ round-bottomed flask were added a stirbar, 506 mg (6.01 mmol) 3-aminoisoxazole, 15 ml_ DMF and 1.04 g (7.75 mmol) N-chlorosuccinimide. The flask was purged with nitrogen and heated at 50 0C for 48 h. The reaction mixture was then concentrated to dryness in vacuo, the residue taken up in DCM and washed with 1 N NaOH containing Na2S2O3. The organic layer was dried over MgSO4, filtered and evaporated to dryness to give a brown oil. Subjecting the residue to FCC (0-5% 2 N NH3 in MeOH/DCM) gave the pure product as a pale- yellow solid (335.4 mg, 47%). MS (ESI+): Calcd for C3H3N2OCI [M+H]+, m/z 117.99, found 119.0 (M + H)+. 1H NMR (500 MHz, CDCI3): 8.10 (s, 1 H), 4.26 (br s, 2H)., 1750-42-1

The synthetic route of 1750-42-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BREITENBUCHER, J., Guy; KEITH, John, M.; TICHENOR, Mark, S.; CHAMBERS, Alison, L.; JONES, William, M.; HAWRYLUK, Natalie, A.; TIMMONS, Amy, K.; MERIT, Jeffrey, E.; SEIERSTAD, Mark, J.; WO2010/68453; (2010); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem