Tag: M.W:0-100

1750-42-1, Isoxazol-3-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 3-aminoisoxazole (0.041 ml, 0.548 mmol) and 1-(5-bromo-4-chloro-2-methoxyphenyl)-2-oxo-1,2-dihydroquinoline-6-sulfonyl chloride (0.254 g, 0.548 mmol) in THF (5.48 ml) was cooled to 0 C., at which point LiHMDS, 1.0M in THF (1.152 ml, 1.152 mmol) was added drop wise. After 40 minutes in the ice bath, the reaction was complete and ammonium chloride (sat aq) was added and the product was extracted with ethyl acetate (*3). The combined organics were dried over magnesium sulfate, filtered and concentrated in vacuo. The crude material was purified via MPLC, eluting with 0-100% ethyl acetate in heptane to yield 1-(5-bromo-4-chloro-2-methoxyphenyl)-N-(isoxazol-3-yl)-2-oxo-1,2-dihydroquinoline-6-sulfonamide (0.096 g, 0.188 mmol, 34.3% yield) as a light-yellow solid. m/z (ESI) 510.0 (M+H)+., 1750-42-1

The synthetic route of 1750-42-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Amgen Inc.; Weiss, Matthew; Boezio, Alessandro; Boezio, Christiane; Butler, John R.; Chu-Moyer, Margaret Yuhua; Dimauro, Erin F.; Dineen, Thomas; Graceffa, Russell; Guzman-Perez, Angel; Huang, Hongbing; Kreiman, Charles; La, Daniel; Marx, Isaac E.; Milgrim, Benjamin Charles; Nguyen, Hanh Nho; Peterson, Emily; Romero, Karina; Sparling, Brian; US9212182; (2015); B2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

14678-05-8, Isoxazol-5-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(4) 2,2,2-Trichloroethyl isoxazol-5-ylcarbamate; To a solution of isoxazole-5-amine (740 mg, 8.80 mmol) and pyridine (2.14 ml, 26.4 mmol) in tetrahydrofuran (10 ml) was added 2,2,2-trichloroethyl chloroformate (1.82 ml, 13.2 mmol) with ice-cooling and the mixture was stirred for 40 minutes with ice-cooling. To the mixture was further added 2,2,2-trichloroethyl chloroformate (1.82 ml, 13.2 mmol) with ice-cooling and the mixture was stirred for 30 minutes with ice-cooling, the reaction mixture was poured into ice-water and the mixture was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (hexane : ethyl acetate = 1 : 1) to obtain the desired product (1.23 g, 53.9%) as a solid. 1H-NMR (CDCl3) delta; 4.87 (2H, s), 6.20 (1H, d, J = 2.1 Hz), 8.00 (1H, br s), 8.18 (1H, d, J = 2.1 Hz).

14678-05-8, As the paragraph descriping shows that 14678-05-8 is playing an increasingly important role.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1813606; (2007); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

1072-67-9, 5-Methylisoxazol-3-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 5-Methyl-3-aminoisoxazole (2 mmol) and aromatic aldehyde (2 mmol) were added to absolute ethanol (4~6 mL) with electromagnetic stirring for about 1 h, followed by adding p-nitroacetophenone (2 mmol) and concentrated HCl (0.1~0.2 mL) with continuous stirring. TLC monitored the reaction progress. Upon completion, the suspension was cooled overnight in a refrigerator (4C). The resulting solid was subsequently collected by filtration. The filter cake was washed successively with water (2×3 mL) and absolute ethanol (2×3 mL), dried to afford the corresponding crude product. The crude product was recrystallized in toluene or a mixed solvent of ethyl acetate and cyclohexane, dried in vacuum to give the pure product with 57.1% ~ 94.9% yields. All compounds were identified by 1H NMR, 13C NMR, ESI-MS and HR MS., 1072-67-9

1072-67-9 5-Methylisoxazol-3-amine 66172, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Article; Liu, Jinyu; Zhou, Zuwen; Liu, Jian; Yan, Jufang; Fan, Li; Tang, Xuemei; Liu, Jie; Chen, Feifei; Yang, Dacheng; Letters in drug design and discovery; vol. 16; 8; (2019); p. 835 – 845;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108511-97-3,Isoxazol-4-amine,as a common compound, the synthetic route is as follows.

1-Chloro-4-iodo-2-trifluoromethylbenzene (10 mmol) obtained in Reaction 1.2 was dissolved in 20 ml of toluene, and isoxazole-4-amine (12 mmol) was sequentially added to the system, palladium acetate ( 0¡¤5 mmol), 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (12 mmol), 3 ml of triethylamine. After stirring for 10 minutes, add 10 ml of cesium carbonate (10 mmol). The aqueous solution is heated to 50 C for 4 hours. After the reaction is completed, 20 ml of water is added to the system, stirred for 20 minutes, and the organic phase is dried over anhydrous sodium sulfate, concentrated, and then purified by flash column chromatography to give 2.2 g. Yellow N-(4-chloro-3-trifluoromethylphenyl)-isoxazole-4-amine powder, yield 84%

108511-97-3, As the paragraph descriping shows that 108511-97-3 is playing an increasingly important role.

Reference£º
Patent; Zhang Ruwei; Ge Baoyin; Jing Fan; (7 pag.)CN108353920; (2018); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.288-14-2,Isoxazole,as a common compound, the synthetic route is as follows.

288-14-2, Example 1 Preparation of 3-(4-Chlorophenyl)-4-Phenyl Isoxazole (Compound of the Formula I wherein R1=H, Y=4-phenyl and Z=4-chlorophenyl). A solution of phenylacetylene (10 mmol), 4-chlorobenzaldoxime (10 mmol) and chloramine-T (10 mmol, N-chloro-p-toluenesulfoneamide, sodium salt) were dissolved in methanol (40 mL) and refluxed for 6 h. The contents of the flask were cooled and the precipitated material, which was a mixture of isoxazole and 4-toluenesulfonamide, was filtered and washed with water. The solid material on boiling in hot water kept the sulfonamide in solution while precipitating the isoxazole. The precipitated isoxazole was filtered and recrystallized from ethanol, yield (82%), m.p.: 178-180 C.; 1H NMR (DMSO-d6) 6.75(s, 1H), 7.49-7.55(m, 5H), 7.77-7.82 (m, 4H).

As the paragraph descriping shows that 288-14-2 is playing an increasingly important role.

Reference£º
Patent; Onconova Therapeutics, Inc.; US2003/162813; (2003); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1072-67-9,5-Methylisoxazol-3-amine,as a common compound, the synthetic route is as follows.

General procedure: To a suspension of 4-hydroxyquinolin-2(1H)-one (7, 1 mmol, 161 mg) in H2O:EtOH(1:1) (8 mL), DBU (20 mol%) was added. The reaction mixture was heated and stirred at 50 C for 15 min to dissolve the reactant. Then, aryl glyoxal monohydrates(1a-h, 1 mmol), 5-methylisoxazol-3-amine (6, 1 mmol, 98 mg) were added to the reaction mixture, which was stirred at the above-mentioned temperature for appropriate times as shown in Table 2. The progress of reaction was controlled by TLC using MeOH:CHCl3/1:10 as eluent. After completion of the reaction, the precipitate was filtered, washed with water and dried to give the desired products 8a-h in high yield (82-89%)., 1072-67-9

As the paragraph descriping shows that 1072-67-9 is playing an increasingly important role.

Reference£º
Article; Aslanpanjeh, Maryam; Poursattar Marjani, Ahmad; Khalafy, Jabbar; Etivand, Nasser; Research on Chemical Intermediates; vol. 46; 1; (2020); p. 165 – 177;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14678-02-5,5-Amino-3-methylisoxazole,as a common compound, the synthetic route is as follows.

(a) 5-Amino-4-chloro-3-methylisoxazole Using the method in Example 1a, 5-amino-4-chloro-3methylisoxazole was prepared in 90% yield from 5-amino-3-methylisoxazole and N-chlorosuccinimide.

14678-02-5, The synthetic route of 14678-02-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Immunopharmaceutics, Inc.; US5514691; (1996); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1750-42-1,Isoxazol-3-amine,as a common compound, the synthetic route is as follows.

(E)-Ethyl 3-(5-(benzylthio)-2-iodophenyl)acrylate (0.225 g, 0.265 mmol) was added to a vial and dissolved in acetonitrile (2.494 ml). Acetic acid (0.095 ml) and water (0.062 ml) were added and the vial was cooled to 0 C. 1,3-dichloro-5,5-dimethylhydantoin (0.057 g, 0.292 mmol) was then added as a solid in one portion while 0 C. was maintained. After 20 min. LC/MS showed mass corresponding to sulfoxide (mono-oxidation) along with sulfonyl chloride. After 1 hr. an additional 0.2 equiv (10 mg) of hydantoin was added. After an additional 20 min. the oxidation was complete. Solid sodium bisulfite was added and the reaction was diluted with EtOAc and water and stirred for 5 min. The organic layer was separated, the aq. re-extracted 2* with EtOAc, and the organic layers combined. After washing with brine, drying with Na2SO4, and concentrating, the crude residue was brought up in 1.5 mL of DCM and treated with 3-aminoisoxazole (0.039 ml, 0.530 mmol) and pyridine (0.107 ml, 1.326 mmol) After 45 min, the reaction was poured into 1N HCl and extracted 2* with EtOAc. The combined organics were washed with brine, dried over Na2SO4, and concentrated to give an orange solid that was purified by MPLC (25 g puriflash, 25-85% EtOAC:Heptanes) to give (E)-ethyl 3-(2-iodo-5-(N-(isoxazol-3-yl)sulfamoyl)phenyl)acrylate (0.043 g, 0.096 mmol, 36.2% yield) as a white solid. m/z (ESI) 447.0 (M-H)-.

1750-42-1, As the paragraph descriping shows that 1750-42-1 is playing an increasingly important role.

Reference£º
Patent; Amgen Inc.; Weiss, Matthew; Boezio, Alessandro; Boezio, Christiane; Butler, John R.; Chu-Moyer, Margaret Yuhua; Dimauro, Erin F.; Dineen, Thomas; Graceffa, Russell; Guzman-Perez, Angel; Huang, Hongbing; Kreiman, Charles; La, Daniel; Marx, Isaac E.; Milgrim, Benjamin Charles; Nguyen, Hanh Nho; Peterson, Emily; Romero, Karina; Sparling, Brian; US9212182; (2015); B2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

1072-67-9, 5-Methylisoxazol-3-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Chlorosulfonyl-3-methoxy-thiophene (3.8 g, 17.87 MMOL), the product from step A of Preparative Example 13.29, was dissolved in 100 mL of CH2CI2 and 20 mL of pyridine. 3-Amino-5-methyl-isoxazole (3.5 g, 35. 68 MMOL) was added. The mixture was stirred for 20 h at room temperature, diluted with 100 mL of CH2CI2, and washed with a 0.5 N HCI aqueous solution (50 mL x 2), H20 (50 mL), and brine (50 mL). The organic solution was dried with NA2SO4, and conentrated in vacuo to a brown oil. This oil was dissolved in 100 mL of CH2CI2, washed again with a 0.5 M HCI aqueous solution (30 mL x 3) and brine. After dried over NA2SO4, the organic solution was concentrated in vacuo to a yellow solid, 4.48 g (91 %, MH+= 275.0) of the desired product., 1072-67-9

1072-67-9 5-Methylisoxazol-3-amine 66172, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; PHARMACOPEIA, INC.; WO2004/33440; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1750-42-1,Isoxazol-3-amine,as a common compound, the synthetic route is as follows.

To a solution of isoxazol-3-amine (313 mg, 3.729 mmol) and imidazole (761 mg, 11.19 mmol) in DCM (9 mL) at -78 C was added SO2Cl2 (503 mg, 3.729 mmol) dropwise. The mixture was warmed to room temperature and stirred for 30 min.1-[5-fluoro-2-methoxy-4-[3-(trifluoromethyl)phenyl]phenyl]- 3,4,4a,5,6,7,8,8a-octahydro-1,6-naphthyridin-2-one (315 mg, 0.7457 mmol) in DCM (1 mL) was then added. The mixture was heated at 80 C for 30 min. The reaction was quenched with water, extracted with DCM (3x). The combined organics were dried (Na2SO4), filtered and concentrated. The crude product was purified by silica flash chromatography (0-10% MeOH/DCM) to give the title compound (235 mg, 55%) as yellow oil. LCMS (ESI) m/z 569 [M+H]+., 1750-42-1

The synthetic route of 1750-42-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; MCKERRALL, Steven; SAFINA, Brian Salvatore; KOLESNIKOV, Aleksandr; ZHANG, Birong; LIU, Wenfeng; LAI, Kwong Wah; (110 pag.)WO2019/191702; (2019); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem