Tag: 83.09

Inhibition of L-asparagine synthetase by a new amino acid antibiotic with antitumor activity. L-(αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-163501) was written by Cooney, David A.;Jayaram, Hiremagalur N.;Ryan, Joan A.;Bono, Vincent H.. And the article was included in Cancer Chemotherapy Reports, Part 1 in 1974.Category: isoxazole This article mentions the following:

NSC-163501 (I) [42228-92-2] and its 4-hydroxy analog NSC-176324 [54549-02-9] inhibited the utilization of L-glutamine [56-85-9] by L-asparagine synthetase (EC 6.3.5.10) [37318-72-2] in mouse pancreas and tumor tissue in vivo and in vitro. Graphic anal. showed the in vitro inhibition to be competitive in nature. L-glutamine in large molar excess effectively antagonized inhibition by these agents, but dialysis experiments showed that estimated inhibition was irreversible. Attempts to show alteration of the inhibitor mol. in the act of catalysis were unsuccessful. In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6Category: isoxazole).

5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. Isoxazole rings are found in some natural products, such as ibotenic acid and muscimol. The electrophilic cyclization of various 2-alkynone O-methyl oximes with a wide range of substrates such as ICl, I2, Br2, PhSeBr, etc. provides a variety of 3,4,5-trisubstituted isoxazoles in good to excellent yields.Category: isoxazole

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

The influence of alkyl substituents on the chromatographic indicator of self-association of N-containing heterocyclic compounds was written by Golovnya, R. V.;Kuz’menko, T. E.;Krikunova, N. I.. And the article was included in Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya) in 2000.Category: isoxazole This article mentions the following:

The chromatog. indicator of the ability of substances to form associates in a pure liquid δT_b.p. proposed in the authors’ previous study was used to estimate the capacity for self-association of alkyl-substituted imidazoles, pyrazoles, pyrroles, oxazoles, isoxazoles, pyridazines, pyrimidines, pyrazines, and pyridines. Alkyl substituents introduced in heterocyclic compounds decrease the δT_b.p. values, which is consistent with the data on the heats of self-association of heterocyclic compounds in pure liquids The reasons for the difference between the b.p. of a compound at standard pressure and its gas-chromatog. b.p. are discussed. In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6Category: isoxazole).

5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. Isoxazole are described as inhibitors of acetylcholinesterase (AChE). Isoxazole ligands bind to and inhibit the Sxc- antiporter. Isoxazoles are potent isosteres of pyridine and have been found to inhibit voltage-gated sodium channels for pain control, for the construction of tetracycline antibiotic derivatives, and as a therapeutic agent for depression.Category: isoxazole

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Synthesis of novel isoxazoline and isoxazolidine derivatives: carboxylic acids and delta bicyclic lactones via the nucleophilic addition of bis(trimethylsilyl)ketene acetals to isoxazoles was written by Rosales-Amezcua, Saulo C.;Ballinas-Indili, Ricardo;Lopez-Reyes, Morelia E.;Rosas-Castaneda, Hector A.;Toscano, R. Alfredo;Alvarez-Toledano, Cecilio. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2021.Category: isoxazole This article mentions the following:

Bis(trimethylsilyl)ketene acetals readily react with activated N-triflyl isoxazoles to selectively afford novel isoxazoline or isoxazolidine derivatives The regioselectivity of the reaction strongly depends on the substrate substituents. When the isoxazole was substituted at the 5-position by a Me or Ph group, the lactonization product, i.e., the isoxazolidine derivative, was formed as a result of double nucleophilic addition of the ketene acetal. When the isoxazole was not substituted, the main product was the corresponding carboxylic acid, i.e., the isoxazoline derivative In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6Category: isoxazole).

5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. Isoxazole rings are found in some natural products, such as ibotenic acid and muscimol. Isoxazole can be synthesised via a variety of methods. Examples include via the reaction of hydroxylamine with 1,3-diketones or derivatives of propiolic acid.Category: isoxazole

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Gold-catalyzed [4+3]- and [4+2]-annulations of 3-en-1-ynamides with isoxazoles via novel 6π-electrocyclizations of 3-azahepta trienyl cations was written by Giri, Sovan Sundar;Liu, Rai-Shung. And the article was included in Chemical Science in 2018.Recommanded Product: 5765-44-6 This article mentions the following:

New gold-catalyzed [4+3]-annulations of 3-en-1-ynamides with isoxazoles afforded 4H-azepines efficiently; this process involved 6π electrocyclizations of gold-stabilized 3-azaheptatrienyl cations. In the presence of Zn(OTf)₂, the resulting 4H-azepines underwent skeletal rearrangement to furnish substituted pyridine derivatives Subsequently a new catalytic [4+2]-annulations was developed between the same 3-en-1-ynamides and isoxazoles to deliver substituted pyridine products using Au(I)/Zn(II) catalysts. The first success of the 6π electrocyclizations of heptatrienyl cations that were unprecedented in literature reports were presented. In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6Recommanded Product: 5765-44-6).

5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. Isoxazoles also form the basis for a number of drugs, including the COX-2 inhibitor valdecoxib (Bextra) and a neurotransmitter agonist AMPA. As with isoxazolines, isoxazoles may be cleaved using low-valent titanium obtained from the Kulinkovich reaction.This procedure affords enaminoketones from 2,4-substituted isoxazoles.Recommanded Product: 5765-44-6

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Nitrogen-15 NMR spectroscopy. Part X. Nitrogen-15 NMR spectra of azoles with two heteroatoms was written by Chen, Ban Chin;Von Philipsborn, Wolfgang;Nagarajan, Kuppuswamy. And the article was included in Helvetica Chimica Acta in 1983.Related Products of 5765-44-6 This article mentions the following:

The ¹⁵N-NMR spectra of azoles, with natural isotope abundance, have been measured under different exptl. conditions, and chem. shifts are reported for imidazoles, pyrazoles, oxazoles, isoxazoles, thiazoles, and isothiazoles. General trends of substituent effects in this heterocyclic series are discussed based on the data of 67 substituted azoles, dihydro- and tetrahydroazoles. ¹⁵N, ¹H spin-coupling constants have been determined from spectra obtained by [¹H] → ¹⁵N polarization-transfer experiments, i.e. an application of INEPT and DEPT pulse sequences. Two-bond and three-bond coupling constants are fully assigned and are discussed in terms of the specific pathways in azoles. The potential of structural applications of the new data is illustrated for isomeric nitro-imidazoles and highly-substituted pyrazoles, and in the case of ring-chain tautomerism of 2-substituted tetrahydrooxazoles. In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6Related Products of 5765-44-6).

5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. Isoxazole rings are found in some natural products, such as ibotenic acid and muscimol. Isoxazole can be synthesised via a variety of methods. Examples include via the reaction of hydroxylamine with 1,3-diketones or derivatives of propiolic acid.Related Products of 5765-44-6

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Synthesis of novel bicyclic 2-amino-4(1H)-pyridones. Reaction of lactim ethers with α-cyanoacetone dianion was written by Jiang, Jack B.;Urbanski, Maud J.. And the article was included in Tetrahedron Letters in 1985.Category: isoxazole This article mentions the following:

Lactim ethers I (X = S, bond; Z = O,S; n = 1-4), treated with C^–H₂COC^–HCN followed by MeOH, yielded bicyclic 2-amino-4(1H)-pyridones II. The dianion was generated in situ by treating 5-methylisoxazole with LiN(CHMe₂)₂. In the absence of MeOH ring closure did not occur. O-, N-, And C-alkylation of II was demonstrated. In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6Category: isoxazole).

5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. Isoxazole are described as inhibitors of acetylcholinesterase (AChE). Isoxazole ligands bind to and inhibit the Sxc- antiporter. Isoxazoles are potent isosteres of pyridine and have been found to inhibit voltage-gated sodium channels for pain control, for the construction of tetracycline antibiotic derivatives, and as a therapeutic agent for depression.Category: isoxazole

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Enthalpies of combustion and formation of 3-methylisoxazole and 5-methylisoxazole was written by Hamilton, Walter S.;Benton, Susan;French, Jennifer;McCormick, Deborah;Pustejovsky, Sharon;Thompson, Patricia. And the article was included in Journal of Chemical and Engineering Data in 1978.HPLC of Formula: 5765-44-6 This article mentions the following:

The enthalpies of combustion of 3-methylisoxazole [30842-90-1] and 5-methylisoxazole [5765-44-6] were measured by precision O-bomb calorimetry. The following values, based on the mass of sample burned, are reported for the standard enthalpy of combustion, ΔH°_c (298.15 K)/kcal_th mol^-1, of these compounds in the liquid state: 3-methylisoxazole, -546.00 ± 0.14; 5-methylisoxazole, -545.65 ± 0.17. Enthalpies of vaporization, determined calorimetrically, are 3-methylisoxazole, 9.51 ± 0.05 kcal mol^-1, and 5-methylisoxazole, 9.48 ± 0.04 kcal mol^-1. These data were used to calculate standard enthalpies of formation for the gaseous compounds, ΔH°_f(g), which are 3-methylisoxazole, 8.52 ± 0.16 kcal mol^-1, and 5-methylisoxazole, 8.14 ± 0.18 kcal mol^-1. Throughout this paper cal_th = 4.184 J and atm = 101.325 kPa. In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6HPLC of Formula: 5765-44-6).

5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives.Synthetically, isoxazoles serve as valuable precursors for the construction of diverse molecules, including many natural products. The most common methods for N–O bond cleavage in isoxazoles are hydrogenation with palladium or platinum catalysts or with Raney Ni. Recent developments have shown that Mo(CO)6 efficiently cleaves the N–O bond in isoxazoles.HPLC of Formula: 5765-44-6

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Synthesis of some polyheterocyclic systems with isolated nuclei was written by Martin, Nazario;Quinteiro, Margarita;Seoane, Carlos;Soto, Jose L.. And the article was included in Revista de la Real Academia de Ciencias Exactas, Fisicas y Naturales de Madrid in 1987.Safety of 5-Methylisoxazole This article mentions the following:

Knoevenagel-type condensation reactions of heterocyclic aldehydes were carried out. Thus, treatment of RCHO (R = pyridyl, pyrrolyl, furyl, etc.) with active methylene compounds PhCOCH₂R¹ (R¹ = CN, CO₂Et) in EtOH containing piperidine afforded benzoylheteroarylacrylonitrile and -acrylates RCH:CR¹COPh (I). The I underwent cyclization with malononitrile to give 4H-pyrans II. In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6Safety of 5-Methylisoxazole).

5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. Isoxazole are described as inhibitors of acetylcholinesterase (AChE). Isoxazole ligands bind to and inhibit the Sxc- antiporter. Isoxazole can be synthesised via a variety of methods. Examples include via the reaction of hydroxylamine with 1,3-diketones or derivatives of propiolic acid.Safety of 5-Methylisoxazole

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Infrared spectra of ion exchanges on polystyrene base was written by Strasheim, A.;Buijs, K.. And the article was included in Spectrochimica Acta in 1961.Name: 5-Methylisoxazole This article mentions the following:

The resins studied were Amberlite IRA-400 and Dowex AG-50. Dispersion media were KBr, petroleum jelly, and hexachlorobutadiene. The spectral range was 700-4000 cm.^-1 The spectrum of a polystyrene film was also obtained for comparison. Vibrational assignments were made for many bands. The functional groups do not all occupy equivalent positions in the resin. In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6Name: 5-Methylisoxazole).

5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. An isoxazolyl group is found in many beta-lactamase-resistant antibiotics, such as cloxacillin, dicloxacillin and flucloxacillin. As with isoxazolines, isoxazoles may be cleaved using low-valent titanium obtained from the Kulinkovich reaction.This procedure affords enaminoketones from 2,4-substituted isoxazoles.Name: 5-Methylisoxazole

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Oxygen-17 nuclear magnetic resonance study of some five-membered heterocyclic derivatives was written by Chimichi, Stefano;Nesi, Rodolfo;De Sio, Francesco. And the article was included in Organic Magnetic Resonance in 1984.Recommanded Product: 5765-44-6 This article mentions the following:

¹⁷O NMR spectra were obtained in the Fourier-transform mode for some furan and isoxazole derivatives The chem. shifts, mainly governed by the electronegativities of the atoms bonded to the central O, are also affected by alkylation on the different positions of the ring systems, which gives rise to β and γ effects similar to those observed for simple aliphatic ethers. In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6Recommanded Product: 5765-44-6).

5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives.Synthetically, isoxazoles serve as valuable precursors for the construction of diverse molecules, including many natural products. As with isoxazolines, isoxazoles may be cleaved using low-valent titanium obtained from the Kulinkovich reaction.This procedure affords enaminoketones from 2,4-substituted isoxazoles.Recommanded Product: 5765-44-6

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem