Category: 5765-44-6

5765-44-6, 5-Methylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5765-44-6, To a solution of 5-methyl isoxazole (5.0 g) in ethyl acetate (100 ml), N-bromo succinate imide (23.6 g) and 2,2′-azobisisobutyronitrile (200 mg) were added to the mixture, and the mixture was refluxed overnight under nitrogen atmosphere. After cooling to 0C, the insolubles were filtered off, the filtrate was washed with an aqueous solution of sodium thiosulfate and saturated brine, and dried over magnesium sulfate. The solvent was distilled off under reduced pressure and the residue was separated and purified by silica gel column chromatography (hexane:ethyl acetate = 10:1), to give 5-bromomethyl isoxazole (1.0 g) as oil. 1H-NMR (200 MHz, CDCl3) delta 4.50 (2H, s), 6.34 (1H, d, J = 1.8 Hz), 8.23 (1H, d, J = 1.8 Hz)

5765-44-6 5-Methylisoxazole 79833, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; EP1422228; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5765-44-6,5-Methylisoxazole,as a common compound, the synthetic route is as follows.,5765-44-6

In 50 ml double-mouth bottle is added sodium hydroxide (0.24 g, 6.0 mmol) and anhydrous methanol (10 ml), in the 30 C dropping under 5 – methyl isoxazole (0.49 ml, 6.0 mmol), then stir at room temperature overnight. Steams solvent, the residue with ethyl ether (80 ml) washing, filtering, the filter cake by vacuum drying to obtain a white solid (0.57 g, 90%).

The synthetic route of 5765-44-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Wang Xiaojun; Zuo Yinglin; Yang Chuanwen; Wang Jiancheng; Wang Hui; (26 pag.)CN109721536; (2019); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

5765-44-6, 5-Methylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5765-44-6

Sodium (7.36 g, 320 mmol) was reacted with ethanol (368 ml) and then 5-methylisoxazole (26.56 g, 320 mmol) was added to the mixture at 20 C. The mixture wasstirred at 20 oc for 1.5 h and at 0 oc for 1.5h. The white solid was collected by filtration,washed with ether, dried in vacuo to provide the titled compound (1 0.168 g, 30%) as awhite solid.

As the paragraph descriping shows that 5765-44-6 is playing an increasingly important role.

Reference£º
Patent; GLAXOSMITHKLINE LLC; LIN, Hong; MOORE, Michael Lee; QU, Junya; RIVERO, Ralph A.; TEDESCO, Rosanna; YU, Hongyi; LUENGO, Juan Ignacio; WO2013/28263; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem