Category: 2510-36-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2510-36-3,3,5-Dimethylisoxasole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

Example 219 3,5-Dimethyl-isoxazole-4-carboxylic acid [4-chloro-5-(l-methyl-2-oxo-l,2,3,4- tetrahydro-quinolin-6-yl)-pyridin-3-ylmethyl]-amideTo a solution of 6-(5-aminomethyl-4-chloro-pyridin-3-yl)-l-methyl-3,4-dihydro-lH- quinolin-2-one hydrochloride (example 218, 0.05 g, 0.148 mmol) in dry DMF (1 mL) were added EDCI (0.034 g, 0.077 mmol), hydroxybenzotriazole (0.017 g, 0.077 mmol), Hunig’s base (0.057 g, 0.443 mmol) and 3,5-dimethyl-isoxazole-4-carboxylic acid (0.021 g, 0.148 mmol) and the resulting solution was stirred at room temperature for 2h. The reaction mixture was diluted with EtOAc, poured into sat. NaHC03 solution (10 mL) and extracted with EtOAc (2 x 20 mL). Combined organics were dried over Na2S04, filtered and evaporated to dryness. The residue was purified by silica gel flash chromatography eluting with a 0 to 5% MeOH-DCM gradient to give the title compound (0.03 g, 48 %) as a colorless solid. MS: 425.4 (M+H+)., 2510-36-3

The synthetic route of 2510-36-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; HORNSPERGER, Benoit; KNUST, Henner; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MAYWEG, Alexander V.; MOHR, Peter; TAN, Xuefei; ZHOU, Mingwei; WO2013/37779; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2510-36-3,3,5-Dimethylisoxasole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

A solution of 2-{3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2- fluorophenyl}acetohydrazide (400 mg, 0.98 mmol), 3,5-dimethyl-4- isoxazolecarboxylic acid (138 mg, 0.98 mmol), HATU (373 mg, 0.98 mmol) and DIPEA (0.34 mL, 1.96 mmol) in THF (5 mL) was heated at 45 C overnight. The reaction was cooled to rt, Burgess Reagent (933 mg, 3.92 mmol) was added and the reaction was stirred overnight. The reaction mixture was diluted with water (20 mL) and extracted with ethyl acetate (3 x 20 mL). The organic extracts were combined, dried over Na2SO4, filtered, concentrated and the crude material was purified by column chromatography (5% to 100% EtOAc/hexanes gradient) to afford the title compound (350 mg, 70%) as a white solid. 1H NMR (400 MHz, DMSO-c/6): delta ppm 7.55-7.48 (m, 3H), 7.15 (t, 1 H), 7.08 (t, 1 H), 4.46 (s, 2H), 2.62 (s, 3H), 2.38 (s, 3H).

2510-36-3, 2510-36-3 3,5-Dimethylisoxasole-4-carboxylic acid 75636, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/157273; (2008); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

2510-36-3, 3,5-Dimethylisoxasole-4-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,2510-36-3

General procedure: A solution of the deprotected azaspiro compound (0.134 mmol) in 2 mL of DMF, 0.14 mL of DIPEA (0.803 mmol), 51.8 mg of EDC (0.268 mmol) and 27.9 mg of HOBT (0.201 mmol) was stirred for 15 min at r.t. Then the proper acid (0.125 mmol) was added to the mixture and the reaction was maintained at 50 C for 12 h with stirring.

The synthetic route of 2510-36-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Francesconi, Valeria; Giovannini, Luca; Santucci, Matteo; Cichero, Elena; Costi, Maria Paola; Naesens, Lieve; Giordanetto, Fabrizio; Tonelli, Michele; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 229 – 243;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2510-36-3,3,5-Dimethylisoxasole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

3,5-Dimethylisoxazole-4-carboxylic acid (0.53 g), dicyclohexylcarbodiimide (1.55 g), HOBT (0.675 g) were dissolved in 30 ml of THF, and stirred for 10 minutes, then 1 g of compound 9 was added. The reaction was carried out under nitrogen for 12 hours.After the completion of the reaction, the reaction mixture was evaporated to dryness crystals crystals crystalsSpin over the column to give a white solid 0.32 g.The yield was 80%.

As the paragraph descriping shows that 2510-36-3 is playing an increasingly important role.

Reference£º
Patent; China Pharmaceutical University; Xiang Hua; Qiu Rongmao; Huang Ali; Zheng Fan; Li Haolin; Yang Qizhen; Hu Weikang; Zhang Jin; Liu Man; Chen Mingqi; Chen Deying; You Qidong; (9 pag.)CN107987116; (2018); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2510-36-3,3,5-Dimethylisoxasole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

Step A 3,5-Dimethyl-isoxazole4-carboxylic acid [2-(4-methoxy-2-methyl-phenylamino)-phenyl]-amide To a solution of N-(4-methoxy-2-methyl-phenyl)-benzene-1,2-diamine (0.200 g, 0.877 mmol), 3,5-dimethylisoxazole4-carboxylic acid (0.186 9, 1.3155 mmol), triethylamine (0.613 mL, 4.385 mmol), and a catalytic amount of 4-Dimethylaminopyridine in CH2Cl2 (2 ml), was added 50%1-propanephosphonic acid cyclic anhydride added (1.05 mL, 1.754 mmol) in ethyl acetate and stirred overnight at room temperature. The reaction material was diluted with CH2Cl2, washed with saturated sodium bicarbonate and extracted into CH2Cl2. The combined organic material was dried (MgSO4), filtered, and concentrated, giving 3,5-dimethyl-isoxazole-4-carboxylic acid [2-(4-methoxy-2-methyl-phenylamino)-phenyl]-amide. MS (M+1) 352.

The synthetic route of 2510-36-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chesworth, Richard; Gegnas, Laura D.; US2004/2524; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem