Category: 2251-79-8

Lobbecke, Stefan published the artcileThermoanalytical screening of nitrogen-rich substances, Formula: C8H5F3N4, the publication is Propellants, Explosives, Pyrotechnics (1999), 24(3), 168-175, database is CAplus.

The thermal decomposition behavior of ∼60 nitrogen-rich tetrazole-class and tetrazine-class compounds was investigated by thermoanal. methods. The decomposition mechanisms initiated by ring opening of the heterocycles could be established. Substituent effects on the exothermic decomposition characteristics of nitrogen-rich compounds were demonstrated.

Propellants, Explosives, Pyrotechnics published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H5F3N4, Formula: C8H5F3N4.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Gutmann, Bernhard published the artcileSafe generation and synthetic utilization of hydrazoic acid in a continuous flow reactor, Safety of 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, the publication is Journal of Flow Chemistry (2012), 8-19, database is CAplus.

Hydrazoic acid (HN₃) was used in a safe and reliable way for the synthesis of 5-substituted-1H-tetrazoles and for the preparation of N-(2-azidoethyl)acylamides in a continuous flow format. Hydrazoic acid was generated in situ either from an aqueous feed of sodium azide upon mixing with acetic acid, or from neat trimethylsilyl azide upon mixing with methanol. For both processes, subsequent reaction of the in situ generated hydrazoic acid with either organic nitriles (tetrazole formation) or 2-oxazolines (ring opening to β-azido-carboxamides) was performed in a coil reactor in an elevated temperature/pressure regime. Despite the explosive properties of HN₃, the reactions could be performed safely at very high temperatures to yield the desired products in short reaction times and in excellent product yields. The scalability of both protocols was demonstrated for selected examples. Employing a com. available bench top flow reactor, productivities of 18.9 g/h of 5-phenyltetrazole and 23.0 g/h of N-(1-azido-2-methylpropan-2-yl)acetamide were achieved.

Journal of Flow Chemistry published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H5F3N4, Safety of 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Yapuri, Umanadh published the artcileLigand-free nano copper oxide catalyzed cyanation of aryl halides and sequential one-pot synthesis of 5-substituted-1H-tetrazoles, Related Products of isoxazole, the publication is Tetrahedron Letters (2013), 54(35), 4732-4734, database is CAplus.

An expedient and sequential one-pot synthesis of 5-substituted-1H-tetrazoles via [2+3] cycloaddition of aryl nitriles with sodium azide is reported. The required aryl nitriles were synthesized via the nano-copper oxide promoted cyanation of aryl iodides generated in situ.

Tetrahedron Letters published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C13H16O2, Related Products of isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Osyanin, Vitaly A. published the artcileAlkylation of 5-aryltetrazoles with 2- and 4-hydroxybenzyl alcohols, Formula: C8H5F3N4, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2015), 51(11-12), 984-990, database is CAplus.

The reaction of salicylic alc. with 5-aryltetrazoles gave mixtures of 2-[(5-aryl-1H-tetrazol-1-yl)methyl]- and 2-[(5-aryl-2H-tetrazol-2-yl)methyl]phenols. In the case of other ortho- and para-hydroxybenzyl alcs., 2,5-disubstituted products were formed selectively. The criteria for detecting 1,5- and 2,5-disubstituted N-benzyltetrazoles by standard 1H and 13C NMR spectroscopy have been identified.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H5F3N4, Formula: C8H5F3N4.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Katane, Masumi published the artcileIdentification of Novel d-Amino Acid Oxidase Inhibitors by in Silico Screening and Their Functional Characterization in Vitro, Computed Properties of 2251-79-8, the publication is Journal of Medicinal Chemistry (2013), 56(5), 1894-1907, database is CAplus and MEDLINE.

D-Amino acid oxidase (DAO) is a degradative enzyme that is stereospecific for d-amino acids, including d-serine and d-alanine, which are potential coagonists of the N-methyl-d-aspartate (NMDA) receptor. Dysfunction of NMDA receptor-mediated neurotransmission has been implicated in the onset of various mental disorders such as schizophrenia. Hence, a DAO inhibitor that augments the brain levels of d-serine and/or d-alanine and thereby activates NMDA receptor function is expected to be an antipsychotic drug, for instance, in the treatment of schizophrenia. In the search for potent DAO inhibitor(s), a large number of compounds were screened in silico, and several compounds were estimated as candidates. These compounds were then characterized and evaluated as novel DAO inhibitors in vitro. The results reported in this study indicate that some of these compounds are possible lead compounds for the development of a clin. useful DAO inhibitor and have the potential to serve as active site probes to elucidate the structure-function relationships of DAO.

Journal of Medicinal Chemistry published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H5F3N4, Computed Properties of 2251-79-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Hosseini-Sarvari, Mona published the artcileNano TiO₂/SO^2-₄ as a heterogeneous solid acid catalyst for the synthesis of 5-substituted-1H-tetrazoles, Synthetic Route of 2251-79-8, the publication is Comptes Rendus Chimie (2014), 17(10), 1007-1012, database is CAplus.

An efficient and economical protocol for the synthesis of 5-substituted-1H-tetrazoles from various nitriles and sodium azide is reported using nano TiO₂/SO^2-₄ as an effective heterogeneous catalyst. A wide variety of aryl nitriles underwent [3 + 2] cycloaddition to afford tetrazoles in good to excellent yields.

Comptes Rendus Chimie published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H5F3N4, Synthetic Route of 2251-79-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Coca, Adiel published the artcilePreparation of 5-substituted 1H-tetrazoles catalyzed by scandium triflate in water, SDS of cas: 2251-79-8, the publication is Synthetic Communications (2015), 45(2), 218-225, database is CAplus.

Several 5-substituted 1H-tetrazoles I (R = 4-O₂NC₆H₄, 4-BrC₆H₄, 4-ClC₆H₄, etc.) were prepared in water or isopropanol/water mixtures using microwave heating. Good yields were obtained for the [2 + 3] cycloaddition of sodium azide with aryl nitriles, aliphatic nitriles, and vinyl nitriles when catalyzed by scandium triflate. The reactions were typically heated for 1h at 160°C in a 3:1 isopropanol/water mixture to obtain the best yields.

Synthetic Communications published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H5F3N4, SDS of cas: 2251-79-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Spinks, Daniel published the artcileDesign, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors, COA of Formula: C8H5F3N4, the publication is ChemMedChem (2012), 7(1), 95-106, database is CAplus and MEDLINE.

Trypanothione synthetase (TryS) is essential for the survival of the protozoan parasite Trypanosoma brucei, which causes human African trypanosomiasis. It is one of only a handful of chem. validated targets for T. brucei in vivo. To identify novel inhibitors of TbTryS we screened our inhouse diverse compound library that contains 62,000 compounds This resulted in the identification of six novel hit series of TbTryS inhibitors. Herein we describe the SAR exploration of these hit series, which gave rise to one common series with potency against the enzyme target. Cellular studies on these inhibitors confirmed on-target activity, and the compounds have proven to be very useful tools for further study of the trypanothione pathway in kinetoplastids.

ChemMedChem published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C4H10O2, COA of Formula: C8H5F3N4.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Kobayashi, Eiji published the artcileFacile one-pot preparation of 5-aryltetrazoles and 3-arylisoxazoles from aryl bromides, Computed Properties of 2251-79-8, the publication is Tetrahedron (2018), 74(31), 4226-4235, database is CAplus.

The successive treatment of aryl bromides with n-BuLi, DMF, hydroxylamine hydrochloride, and finally diphenylphosphoryl azide provided efficiently the corresponding 5-aryltetrazoles in good to moderate yields. Similarly, the successive treatment of aryl bromides with n-BuLi, DMF, hydroxylamine hydrochloride, and finally di-Et acetylenedicarboxylate and Oxone provided efficiently the corresponding di-Et 3-arylisoxazole-4,5-dicarboxylates in good to moderate yields. Aromatic aldoximes are the key intermediates in both reactions, and 5-aryltetrazoles and 3-arylisoxazoles could be obtained from aryl bromides in one pot under transition-metal-free conditions.

Tetrahedron published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H5F3N4, Computed Properties of 2251-79-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Seliverstova, D. V. published the artcileSynthesis, Structure, and Anti-influenza Activity of 2-(Adamantan-1-yl)-5-aryl-1,3,4-oxadiazoles and 2-(Adamantan-1-yl)-5-aryltetrazoles, Recommanded Product: 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, the publication is Russian Journal of Organic Chemistry (2018), 54(4), 633-638, database is CAplus.

Two series of new adamantyl derivatives of polynitrogen heterocycles, 2-(adamantan-1-yl)-5-aryl- 1,3,4-oxadiazoles and 2-(adamantan-1-yl)-5-aryl-2H-tetrazoles, have been synthesized, and their structure has been determined by NMR spectroscopy, mass spectrometry, and X-ray anal. Biol. studies in vitro have revealed high inhibitory activity of some of the synthesized 2-(adamantan-1-yl)-5-aryl-2H-tetrazoles against H1N1 influenza A viruses in combination with a relatively low selectivity.

Russian Journal of Organic Chemistry published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C7H6Cl2O, Recommanded Product: 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem