Month: October 2022

Kalkote, Uttam R.; Goswami, Das D. published the artcile< New synthesis of 1,2-benzisoxazole derivatives>, Related Products of 21725-69-9, the main research area is benzisoxazole; salicylohydroxamic acid thionyl chloride cyclization; acetophenone oxime hydroxy cyclization; salicylaldoxime cyclization thionyl chloride.

N-Phenylsalicylohydroxamic acids (I, R = H, Cl, Br, I) were treated with SOCl2 in the presence of pyridine in anhydrous ether at 0° to give II (via III). IV (R3 = H, OH, Me; R2 = H, Me, Cl, Br, etc.) were similarly treated to give V.

Australian Journal of Chemistry published new progress about 21725-69-9. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Related Products of 21725-69-9.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Kinstle, Thomas H.; Darlage, Larry J. published the artcile< Thermal conversion of 3-hydroxy-1,2-benzisoxazole to benzoxazolinone>, HPLC of Formula: 21725-69-9, the main research area is benzisoxazoles pyrolysis; pyrolysis benzisoxazoles; oxazolinones benz; benzoxazolinones; isoxazoles benz pyrolysis.

3-Hydroxy-1,2-benzisoxazole (I), prepared according to known methods, is pyrolyzed at 0.10 mm. at 340-450° to give benzoxazolinone (II); N.M.R. data for II are given; ir data are given for I and II. Mechanisms in which the nitrene, o-HOC6H4CON, and 3,5-cyclohexadien-1-one-2-spiro-3′-aziridin-2′-one are intermediates are discussed.

Journal of Heterocyclic Chemistry published new progress about 21725-69-9. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, HPLC of Formula: 21725-69-9.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Uno, Hitoshi; Kurokawa, Mikio published the artcile< Studies on 3-substituted 1,2-benzisoxazole derivatives. IV. Rearrangement of N-substituted 2H-1,2-benzisoxazolin-3-one to 2-substituted 2H-1,3-benzoxazin-4-one>, Category: isoxazole, the main research area is benzoxazinone; benzisoxazolinone ring expansion rearrangement; alkylation hydroxybenzisoxazole.

The base catalyzed ring expansion of 2-substituted 2H-1,2-benzisoxazolin-3-ones I (R = Ph, CO2Me, COPh, COMe, CCH, R1 = H; R = R1 = Ph; R = CO2Et, R1 = Me) to 2-substituted 2H-1,3-benzoxazin-4-ones II occurred during the alkylation of hydroxy-1,2-benzisoxazole.

Chemical & Pharmaceutical Bulletin published new progress about Rearrangement. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Category: isoxazole.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Sieser, Janice E.; Singer, Robert A.; McKinley, Jason D.; Bourassa, Dennis E.; Teixeira, John J.; Long, James published the artcile< Synthesis of a bicyclic piperazine from l-aspartic acid and application of a fluoride-promoted SNAr coupling>, Electric Literature of 21725-69-9, the main research area is benzoisoxazolyloctahydropyridopyrazinylmethanol preparation chem resolution nucleophilic aromatic substitution.

The process development is reported of a pivotal C-N bond formation involving ((7R,9aS)-octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol I undergoing nucleophilic aromatic substitution with 3-chlorobenzo[d]isoxazole to furnish ((7R,9aS)-2-(benzo[d]isoxazol-3-yl)octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol II(R = H) as a key intermediate for a family of compounds II(R =aryl). Essential to the success of the coupling is the use of fluoride in combination with a phase transfer catalyst. The development of an alternative route to bicyclic piperazine II (R = H) that uses L-aspartic acid as a starting material to avoid the need for a classical salt resolution is described.

Organic Process Research & Development published new progress about Cyclization. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Electric Literature of 21725-69-9.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Szilagyi, Bence; Kovacs, Peter; Ferenczy, Gyorgy G.; Racz, Anita; Nemeth, Krisztina; Visy, Julia; Szabo, Pal; Ilas, Janez; Balogh, Gyorgy T.; Monostory, Katalin; Vincze, Istvan; Tabi, Tamas; Szoko, Eva; Keseru, Gyorgy M. published the artcile< Discovery of isatin and 1H-indazol-3-ol derivatives as D-amino acid oxidase (DAAO) inhibitors>, Category: isoxazole, the main research area is isatin indazolol derivative preparation amino acid oxidase inhibitor schizophrenia; Binding thermodynamics; Optimization; Protonation state; d-Amino acid oxidase.

D-Amino acid oxidase (DAAO) is a potential target in the treatment of schizophrenia as its inhibition increases brain D-serine level and thus contributes to NMDA receptor activation. Inhibitors of DAAO were sought testing [6+5] type heterocycles and identified isatin derivatives as micromolar DAAO inhibitors. A pharmacophore and structure-activity relationship anal. of isatins and reported DAAO inhibitors led the authors to investigate 1H-indazol-3-ol derivatives and nanomolar inhibitors were identified. The series was further characterized by pKa and isothermal titration calorimetry measurements. Representative compounds exhibited beneficial properties in in vitro metabolic stability and PAMPA assays. 6-Fluoro-1H-indazol-3-ol (37) significantly increased plasma D-serine level in an in vivo study on mice. These results show that the 1H-indazol-3-ol series represents a novel class of DAAO inhibitors with the potential to develop drug candidates.

Bioorganic & Medicinal Chemistry published new progress about Antipsychotics. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Category: isoxazole.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Yoshji, Kiyotaka; Ohba, Yoshihiro; Nishiwaki, Tarozaemon published the artcile< β-Ribo- and α-arabinonucleosides containing the 1,2-benzisoxazole and 1,2-benzisothiazole rings>, Quality Control of 21725-69-9, the main research area is benzisoxazole containing ribonucleoside arabinonucleoside; benzisothiazole containing ribonucleoside; ribofuranose condensation benzisoxazole benzisothiazole; arabinofuranose condensation benzisoxazole.

The reaction of the silylated base of 1,2-benzisoxazol-3(2H)-one (I, R = R1 = H, X = O), its 7-Me derivative I (R = Me, R1 = H, X = O), and the 5-methylbenzisothiazolone I (R = H, R1 = Me, X = S), resp., with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose followed by basic deprotection gave the corresponding β-D-ribonucleosides II. Similarly, 1-O-acetyl-2,3,5-tri-O-benzoyl-α-D-arabinofuranose reacted with I (R = R1 = H, X = O) in the presence of stannic chloride, to afford the corresponding α-arabinonucleoside III. Structural proofs for these nucleosides are provided from elemental analyses and 1H and 13C NMR spectra.

Journal of Heterocyclic Chemistry published new progress about Glycosylation. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Quality Control of 21725-69-9.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Domagalina, E.; Slawik, T. published the artcile< Thermoanalytical studies of organic compounds. Part V. Rearrangement of acylated 3-hydroxy-1,2-benzisoxazoles>, Product Details of C7H5NO2, the main research area is benzisoxazole acyl thermal decomposition; benzoxazolinone acyl.

Thermal anal. of new benzoyl- and methoxy- and ethoxycarbonyl-3-hydroxybenzisoxazole (e.g., I) was carried out derivatog. In the serial stages of tautomeric, isomeric and decarboxylic transformation, new N-acylated benzisoxazolin-3-ones and -2-ones and 3-alkylbenzoxazolin-2-ones were obtained.

Journal of Thermal Analysis published new progress about Thermal decomposition. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Product Details of C7H5NO2.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Zhang, Xuqing; Qiu, Yuhong; Li, Xiaojie; Bhattacharjee, Sheela; Woods, Morgan; Kraft, Patricia; Lundeen, Scott G.; Sui, Zhihua published the artcile< Discovery and structure-activity relationships of a novel series of benzopyran-based KATP openers for urge urinary incontinence>, Computed Properties of 21725-69-9, the main research area is hydroxybenzopyran stereoselective preparation sulfonylurea receptor modulator potassium channel opener; structure hydroxybenzopyran potassium channel opening activity selectivity sulfonylurea receptor.

Substituted hydroxybenzopyrans such as hydroxybenzopyranyl benzoisoxazolone I are prepared as selective modulators of sulfonylurea receptors (SUR) in ATP-sensitive potassium channels for use as potassium channel openers for treatment of urinary incontinence. The structure-activity relationships of 4-substituted benzopyranols are evaluated. I shows EC50 values of 0.67 μM in SUR2B-containing cells, 99.8 μM in SUR1-containing cells, and 1.67 μM in SUR2A-containing cells; in two rat models of myogenic bladder overactivity, I inhibits spontaneous bladder contractions.

Bioorganic & Medicinal Chemistry published new progress about ATP-sensitive potassium channels Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Computed Properties of 21725-69-9.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Ueda, Mitsuru; Harada, Toshiaki; Aoyama, Shigeto; Imai, Yoshio published the artcile< Synthesis of polyamides from active diacyl derivatives of 3-hydroxy-1,2-benzisoxazole and diamines under mild conditions>, Application In Synthesis of 21725-69-9, the main research area is benzisoxazole ester amide polymer; polyamide benzisoxazole; aminolysis benzoisoxazole ester amide.

New active diesters and diamides derived by O- or N-acylation of 3-hydroxy-1,2-benzisoxazole [21725-69-9] were prepared for use in polyamide synthesis. The active esters and amides reacted readily with amines to give quant. yields of amides. The high reactivity of these active esters and amides was discussed in relation to the electron-withdrawing effect of the leaving group and intramol. general-base catalysis. Solution polycondensation of the new diesters and diamides with aliphatic and aromatic diamines proceeded slowly under mild conditions to produce polyamides with inherent viscosities up to 1.5.

Journal of Polymer Science, Polymer Chemistry Editionpublished new progress about Aminolysis. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Application In Synthesis of 21725-69-9.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Van Eker, Daniel; Chauhan, Jay; Murphy, William A.; Conlon, Ivie L.; Fletcher, Steven published the artcile< Chromatography-free, Mitsunobu-triggered heterocyclizations of salicylhydroxamic acids to 3-hydroxybenzisoxazoles>, Quality Control of 21725-69-9, the main research area is hydroxybenzisoxazole preparation; salicylhydroxamic acid heterocyclization Mitsunobu.

A swift and efficient preparation of 3-hydroxybenzisoxazoles I (R = H, 6-F, 6-Cl, 7-OCH3, 5-NO2, etc.) by the Mitsunobu-triggered heterocyclizations of salicylhydroxamic acids, which can be isolated by an acid-base work-up was reported. As expected, a range of functional groups was compatible with the chem.

Tetrahedron Letterspublished new progress about Heterocyclization. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Quality Control of 21725-69-9.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem