Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5765-44-6,5-Methylisoxazole,as a common compound, the synthetic route is as follows.,5765-44-6

In 50 ml double-mouth bottle is added sodium hydroxide (0.24 g, 6.0 mmol) and anhydrous methanol (10 ml), in the 30 C dropping under 5 – methyl isoxazole (0.49 ml, 6.0 mmol), then stir at room temperature overnight. Steams solvent, the residue with ethyl ether (80 ml) washing, filtering, the filter cake by vacuum drying to obtain a white solid (0.57 g, 90%).

The synthetic route of 5765-44-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Wang Xiaojun; Zuo Yinglin; Yang Chuanwen; Wang Jiancheng; Wang Hui; (26 pag.)CN109721536; (2019); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

13999-39-8, 3-Amino-4,5-dimethylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[19]; 2-(6-Chlorobenzotriazol-l-yl)-l,l,3,3-tetramethyluronium tetrafluoroborate was used in place of 2-(7-azabenzotriazol-l-yl)-l,l,3,3-tetramethyluronium hexafluorophosphate(V) as the coupling agent. The reaction product was purified using column chromatography on silica and a solvent gradient from methylene chloride to a 19:1 mixture of methylene chloride and methanol as eluent. The product gave the following characterising data :- 1H NMR Spectrum: (DMSOd6) 1.8 (s, 3H), 2.3 (s, 3H), 3.71 (s, 2H)5 3.78 (s, 3H)5 4.02 (s, 3H)5 6.53 (d, IH)5 6.89 (m, IH), 7.04 (d, IH), 7.23 (s, IH), 7.38 (d, IH), 8.77 (d, IH)5 9.43 (s, IH), 10.27 (br s, IH); Mass Spectrum: M+H+ 435., 13999-39-8

As the paragraph descriping shows that 13999-39-8 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/113565; (2007); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33282-16-5,5-(4-Methoxyphenyl)isoxazole-3-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: To a solution of oximic acid (4a-k, 3.6 mmol in 50 mL THF) was added HOBt (3.6 mmol) in an ice-cooled bath. Next, a mixture of cystamine dihydrochloride (1.8 mmol) and TEA (1 mL) in DMSO (6 mL) were added, followed by the addition of EDCI (4.0 mmol). After stirring for 24 h at room temperature, the reaction was quenched with water and extracted with EtOAc (60 mL ¡Á 3). The combined organic extracts were washed with brine (50 mL), dried over MgSO4 and then evaporated. The resulting residue was then purified by column chromatography on silica gel as indicated.

33282-16-5, As the paragraph descriping shows that 33282-16-5 is playing an increasingly important role.

Reference£º
Article; Wen, Jiachen; Bao, Yu; Niu, Qun; Liu, Jiang; Yang, Jinyu; Wang, Wanqiao; Jiang, Tao; Fan, Yinbo; Li, Kun; Wang, Jian; Zhao, Linxiang; Liu, Dan; Bioorganic and Medicinal Chemistry Letters; vol. 26; 17; (2016); p. 4372 – 4376;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

1136-45-4, 5-Methyl-3-phenylisoxazole-4-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1136-45-4, 5-Methyl-3-phenylisooxazole-4-carboxylic acid (40 mg, 0.197 mmol), 4-hydroxy-4-phenylpiperidine (28.8 mg, 0.151 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (37.7 mg, 0.197 mmol) and triethylamine (59.8 mg, 0.591 mmol) were mixed in dichloromethane (2 mL) and stirred at room temperature over night. Solvent was evaporated in vacuo, and the residue was taken up in methanol (1 mL), filtered and purified by preparative chromatography. The combined fractions were partitioned between NaHCO3 (sat) and ethylacetate. The organic layer was washed with water and concentrated in vacuo to afford the title compound. HRMS (ESI, pos. ion) m/z calcd for C22H22N2O3: 362.1630, found 362.1627.

The synthetic route of 1136-45-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Amgen Inc.; Biovitrum AB; US2008/21022; (2008); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

13999-39-8, 3-Amino-4,5-dimethylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The iV-(4,5-dimethylisoxazol-3-yl)-2-(4-hydroxy-2-methoxyphenyl)acetamide used as starting material was prepared as follows :-Using a similar procedure to that described in the portion of Example 17 that is concerned with the preparation of starting materials, 2-(4-benzyloxy-2-methoxyphenyl)acetic acid (0.1 g) was reacted with oxalyl chloride (0.093 ml) and DMF (3 drops) in methylene chloride (5 ml). The reaction mixture was stirred at ambient temperature for 1 hour. The mixture was evaporated to give 2-(4-benzyloxy-2-methoxyphenyl)acetyl chloride. A mixture of the material so obtained, 3-amino-4,5-dimethylisoxazole (0.062 g), diisopropylethylamine (0.065 ml), 4-dimethylaminopyridine (0.005 g) and methylene chloride (5 ml) was stirred at ambient temperature for 14 hours. The resultant mixture was evaporated and the residue was purified by column chromatography on silica using increasingly polar mixtures of methylene chloride and ethyl acetate as eluent. There was thus obtained iV-(4,5-dimethylisoxazol-3-yl)- 2-(4-benzyloxy-2-methoxyphenyl)acetamide; 1H NMR: (DMSOd6) 1.77 (s, 3H), 2.28 (s, 3H), 3.55 (s, 2H)5 3.74 (s, 3H)5 5.09 (s, 2H)5 6.54 (m, IH)5 6.63 (d, IH)5 7.09 (d, IH)5 7.33 (m, IH)5 7.39 (m, 2H)5 7.45 (m, 2H), 10.15 (br s, IH); Mass Spectrum: M+H+ 367.

13999-39-8, As the paragraph descriping shows that 13999-39-8 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/99326; (2007); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31329-64-3,3,5-Dimethylisoxazol-4-amine,as a common compound, the synthetic route is as follows.

EXAMPLE 8 7-Difluoromethoxy-2-(tetrahydrofuran-3-yl)-benzofuran-4-carboxylic acid (3,5-dimethylisoxazol-4-yl)-amide Oxalyl chloride (0.09 ml) was added to a stirred solution of 7-difluoromethoxy-2-(tetrahydrofuran-3-yl)-benzofuran-4-carboxylic acid (0.15 g) in dry dichloromethane (20 ml) at room temperature under a dry nitrogen atmosphere. N,N-dimethylformamide (catalytic amount) was added and the reaction allowed to stir for 2 hours. The solvent was removed in vacuo to furnish the corresponding acid chloride as a yellow oil. 3,5-Dimethylisoxazol-4-ylamine (0.11 g) was added to a stirred solution of the acid chloride in dry dichloromethane (30 ml) at room temperature under a dry nitrogen atmosphere. Triethylamine (0.14 ml) was added and the reaction allowed to stir at room temperature for 2 hours. The reaction was washed with water (30 ml) and 1N hydrochloric acid (30 ml). The organic phase was dried over magnesium sulphate, filtered and preadsorbed onto silica. Purification by column chromatography on silica eluding with 30% heptane in ethyl acetate yielded the title compound as a white solid (0.16 g). TLC Rf 0.17 (50% ethyl acetate in heptane) Mp 155.5-156.5 C.

31329-64-3, The synthetic route of 31329-64-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Dyke, Hazel Joan; Lowe, Christopher; Montana, John Gary; US2001/31777; (2001); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.181696-35-5,4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonic acid,as a common compound, the synthetic route is as follows.

5-methyl-3-phenyl-4- (4-sulfonic acid phenyl) isoxazole 11.7g (50mmol) dissolved in dichloromethaneOf thionyl chloride was added dropwise 9.3g (100mmol) at 0 ~ 5 reaction was stirred 40 minutes,Quenched with ice water, extracted with dichloromethane,Methylene chloride phase directly into the aqueous ammonia,The reaction temperature was raised to 20 deg.] C continued for 1 hourAfter the reaction, dichloromethane extraction,Washed, concentrated,Methanol to obtain 14.4 g of vediloxib,The yield was 91.4% and the purity was 99.54%.

181696-35-5, 181696-35-5 4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonic acid 11565904, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Wang, Xiaoyue; (7 pag.)CN106008387; (2016); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.123770-62-7,Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.

Reference Production Example 293 (0936) Ethyl 5-hydroxymethylisoxazole-3-carboxylate (0.86 g, 5.0 mmol) was added to dry tetrahydrofuran (25 ml), under a nitrogen atmosphere, and the mixture was cooled to 0C. 60% sodium hydride (0.40 g, 10.0 mmol) was added thereto, and the mixture was further stirred for 30 minutes. 2-Methoxybenzyl chloride (0.94 g, 6.0 mmol) was added thereto, and the reaction solution was heated to room temperature, and then the mixture was stirred for 16 hours. The reaction mixture was poured into a saturated aqueous ammonium chloride solution, and the mixture was extracted twice with ethyl acetate. The organic layer was washed with water and saturated saline water, and then dried over sodium sulfate. The solvent was concentrated under reduced pressure, then the residue was added to ethanol (25 mL), and 2 N sodium hydroxide (15 mL) was added thereto, and then the mixture was stirred at room temperature for 16 hours. Thereafter, the resulting mixture was concentrated under reduced pressure. Dilute hydrochloric acid was added to the reaction mixture, the mixture was cooled to 0C, and the precipitated solid was filtered. The solid was dried under reduced pressure to obtain 1.15 g of 5-(2-methoxybenzyloxymethyl)isoxazole-3-carboxylic acid represented by the following formula. 1H-NMR(CDCl3, TMS, delta(ppm)) : 7.28-7.35(m, 2H), 6.87-6.97(m, 2H), 6.74(s, 1H), 4.71(s, 2H), 4.65(s, 2H).3.83(s, 3H), 123770-62-7

As the paragraph descriping shows that 123770-62-7 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

2510-36-3, 3,5-Dimethylisoxasole-4-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2510-36-3, General procedure: The aldehyde (0.8 equivalent) and amine (0.7 equivalent) were dissolved in methanol (2.0 mL) and stirred for two to 3 h depending upon the starting material. The acid (100 mg, 1 equivalent) and isocyanide (0.7 equivalent) were added in the reaction mixture and further stirred. The reaction mixture was monitored using TLC analysis.Water (4 mL) was added upon completion of the reaction.The resulted solid was filtered off and dissolved in ethyl acetate(10 mL), washed with water (2 3 mL) and dried over sodium sulphate. The crude product was purified using silica gel column chromatography. The ethyl acetate:hexane (6:4) solvent system was used for the purification of these compounds.

The synthetic route of 2510-36-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Makane, Vitthal B.; Krishna, Vagolu Siva; Krishna, E. Vamshi; Shukla, Manjulika; Mahizhaveni; Misra, Sunil; Chopra, Sidharth; Sriram, Dharmarajan; Dusthackeer, V.N. Azger; Rode, Haridas B.; European Journal of Medicinal Chemistry; vol. 164; (2019); p. 665 – 677;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.

62348-13-4, To PS-HOBT resin (0.1 mmol) was added anhydrous dichloromethane (“DCM”) (1 mL) followed by pyridine (0.5 mmol) and isoxazole-5-carbonyl chloride (Lancaster) (0.3 MMOL). The mixture was shaken at room temperature for 3 h and was then filtered. The resin was washed successively with tetrahydrofuran (“THF”) (3x) and DCM (3x) and dried III vacuo. To this acylated resin was added a solution of 2- piperidinoaniline (Lancaster) (0.05 mmol, 0.5 eq) in anhydrous THF (1 mL) and the mixture was shaken at room temperature for 16 H. THE MIXTUE WAS THEN FILTERED AND the resin washed with THF and DCM as described above. The combined filtrate and washings were concentrated under reduced pressure to yield the product. Yield: 100%. MS: 272 (M+1). LC/MS PURITY : 100%. IHNMR (CDCL3, 300MHZ) : 58. 2 (d, 1H), 7.85 (t, 2H), 7.55 (m, 1H), 7.4 (m, 2H), 3.8-3. 2 (bm, 4H), 2.7-1. 9 (bm, 4H).

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Patent; 3-DIMENSIONAL PHARMACEUTICALS, INC.; WO2004/96795; (2004); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem