Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7063-99-2,Ethyl 5-phenylisoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.

7063-99-2, General procedure: Sodium hydroxide (2N) was added to a solution of intermediate 2a-i (1 equiv.) in methanol at ambient temperature. The reaction mixture was stirred for 4h and the methanol was removed by rotary evaporation. The resultant mixture was adjusted to pH=5-6 with 1N HCl solution. The precipitated white solid was collected by filtration and dried to give the carboxylic acid intermediate (1a-i). 4.13.1 5-Phenylisoxazole-3-carboxylic acid(1a) (0032) Light white solid; yield: 91.5%; 1H NMR (600MHz, DMSO-d6) delta 7.95 (dd, J=7.8, 1.7Hz, 2H), 7.58-7.53 (m, 3H), 7.41 (s, 1H).

As the paragraph descriping shows that 7063-99-2 is playing an increasingly important role.

Reference£º
Article; Zhao, Shizhen; Zhang, Xiangqian; Wei, Peng; Su, Xin; Zhao, Liyu; Wu, Mengya; Hao, Chenzhou; Liu, Chunchi; Zhao, Dongmei; Cheng, Maosheng; European Journal of Medicinal Chemistry; vol. 137; (2017); p. 96 – 107;,
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33282-15-4, 5-(4-Hydroxyphenyl)isoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of oximic acid (4a-k, 3.6 mmol in 50 mL THF) was added HOBt (3.6 mmol) in an ice-cooled bath. Next, a mixture of cystamine dihydrochloride (1.8 mmol) and TEA (1 mL) in DMSO (6 mL) were added, followed by the addition of EDCI (4.0 mmol). After stirring for 24 h at room temperature, the reaction was quenched with water and extracted with EtOAc (60 mL ¡Á 3). The combined organic extracts were washed with brine (50 mL), dried over MgSO4 and then evaporated. The resulting residue was then purified by column chromatography on silica gel as indicated., 33282-15-4

The synthetic route of 33282-15-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wen, Jiachen; Bao, Yu; Niu, Qun; Liu, Jiang; Yang, Jinyu; Wang, Wanqiao; Jiang, Tao; Fan, Yinbo; Li, Kun; Wang, Jian; Zhao, Linxiang; Liu, Dan; Bioorganic and Medicinal Chemistry Letters; vol. 26; 17; (2016); p. 4372 – 4376;,
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Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33282-23-4,5-(4-Bromophenyl)isoxazole-3-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: A solution of isoxazole acid derivative 1 (1mmol), EDCI (1.1mmol), and HOBt (1mmol) in dry acetonitrile (10mL) was stirred at room temperature for 30min. Then, 3-picolylamine 2a or 4-picolylamine 2b (1mmol) was added drop wise to the mixture and the reaction was continued at room temperature for 24h. After completion of the reaction, the solvent was reduced under vacuum and the residue was dissolved in dichloromethane and washed with sodium carbonate (10%, 3¡Á20). The organic phase was dried over Na2SO4 and the solvent was evaporated under vacuum to give compound 3 which was completely pure. Finally, the mixture of compound 3 (1mmol) and benzyl halide derivative 4 (1.2mmol) in dry acetonitrile (10mL) was heated at reflux for 10-15h. After completion of the reaction which was monitored by TLC, the mixture was allowed to be cool and the precipitates were filtered off to afford products 5a-q in good yields., 33282-23-4

The synthetic route of 33282-23-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Vafadarnejad, Fahimeh; Karimpour-Razkenari, Elahe; Sameem, Bilqees; Saeedi, Mina; Firuzi, Omidreza; Edraki, Najmeh; Mahdavi, Mohammad; Akbarzadeh, Tahmineh; Bioorganic Chemistry; vol. 92; (2019);,
Isoxazole – Wikipedia
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51677-09-9,51677-09-9, Methyl 5-phenylisoxazole-3-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of substrate 1 (1.0 equiv) in THF (0.2 M) was added Grignardreagent (5.0 equiv) or organolithium reagent (2.0 or 3.0 equiv) at -78 C and the resulting solution wasstirred at the same temperature under Ar. After the substrate 1 was consumed or the reaction did not proceedany more (judged by TLC), sat. NH4Cl aq. was added to the reaction mixture and the resultingsolution was warm to rt and extracted with AcOEt. The combined organic layer was dried overNa2SO4 and concentrated in vacuo. The crude product was purified by flash column chromatography onsilica gel.p-Fluorophenylmagnesium chloride was prepared form p-fluoroiodobenzene and iPrMgCl according to theliterature.4Organolithium reagents were prepared by adding n-butyl lithium (hexane solution, 1.0 equiv) to a solution ofalkyne (1.1 equiv) in THF (0.8M) at -78 C and stirring at rt for 1 h.

As the paragraph descriping shows that 51677-09-9 is playing an increasingly important role.

Reference£º
Article; Murai, Kenichi; Miyazaki, Shuji; Fujioka, Hiromichi; Tetrahedron Letters; vol. 53; 29; (2012); p. 3746 – 3749;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.946426-89-7,5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazole-4-methanol,as a common compound, the synthetic route is as follows.

To a solution of Compound 24a (120 mg, 0.31 mmol) and Compound INT-003 (90 mg, 0.32 mmol) in toluene (3 mL) was added CS2CO3 (200 mg, 0.61 mmol), Rockphos (13 mg, 0.03 mmol), [PdCl(allyl)]2(4 mg, 0.01 mmol). The reaction was stirred for 4 h at 80C under N2atmosphere. The filtrate was concentrated under vacuum after filtration. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1 : 1) This resulted in 110 mg (61%) of the title compound as a solid. LC-MS (ESI, m/z): [M+H]+= 582.3

946426-89-7, The synthetic route of 946426-89-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HEPAGENE THERAPEUTICS, INC.; XU, Xiaodong; (106 pag.)WO2018/75207; (2018); A1;,
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Isoxazole | C3H3NO – PubChem

51677-09-9,51677-09-9, Methyl 5-phenylisoxazole-3-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of substrate 1 (1.0 equiv) in THF (0.1 M) was added Grignardreagent (10 equiv) at -78 C and stirred at the same temperature under Ar. After the substrate 1 wasconsumed or the reaction did not proceed any more (judged by TLC), sat. NH4Cl aq. at -78 C was added tothe reaction mixtures and the resulting solution was extracted with AcOEt. The combined organic layerwas dried over Na2SO4 and concentrated in vacuo. The ratio of substrate 1, ketone 2, and tertiaryalcohol 3 was determined by 1H NMR spectrum of crude reaction mixtures.Tertiary alcohol 3ab-3db was prepared by the reaction of substrate 1 and Grignard reagent at rt.

The synthetic route of 51677-09-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Murai, Kenichi; Miyazaki, Shuji; Fujioka, Hiromichi; Tetrahedron Letters; vol. 53; 29; (2012); p. 3746 – 3749;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

946426-89-7, 5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazole-4-methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 5 4-Bromomethyl-5-cyclopropyl-3-f2.6-dichloro-phenvD-isoxazoleTo a 0 C solution of (5-cyclopropyl-3-(2,6-dichloro-phenyl)-isoxazol-4-yl)-methanol (0.124 g,0.44 mmol) in dichloromethane (4 mL) is added phosphorous tribromide (0.261 g, 0.963 mmol). The ice bath is removed after 20 minutes and the reaction is allowed to stir for an additional twenty minutes at room temperature. The reaction mixture is quenched with pH 7 buffer and extracted with dichloromethane several times. The organic layers are combined, washed with brine, dried over sodium sulfate, filtered, and concentrated under reduced pressure to yield the title compound (0.124 g, 82%). 1H-NMR (400 MHz CDCl3) delta 7.45-7.33 (m, 3H), 4.20(s, 2H), 2.09 (m, IH), 1.27 (m, 2H), 1.16 (m, 2H).

946426-89-7, 946426-89-7 5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazole-4-methanol 45790382, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2007/92751; (2007); A2;,
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Isoxazole | C3H3NO – PubChem

33282-23-4, 5-(4-Bromophenyl)isoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of carboxylic acid 21-29 (1 equiv) in anhydrous CH2Cl2 were successively added HBTU (1.5 equiv), HOBt (0.5 equiv) and DIPEA (2 equiv). The mixture was stirred for 45 min at room temperature. Then, the appropriate amine (1.1 equiv) was introduced and the stirring was continued for 24 h. At the end of the reaction, the mixture was filtered off and the filtrate was successively washed with saturated aqueous NaHCO3 solution, 1N aqueous HCl and distilled water. The organic layer was dried over MgSO4 and was concentrated in vacuo. The resulting residue was purified by TLC (cyclohexane/AcOEt, 7:3) and crystallized in absolute EtOH to give carboxamide 30-48.

33282-23-4, The synthetic route of 33282-23-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Andrzejak, Virginie; Muccioli, Giulio G.; Body-Malapel, Mathilde; El Bakali, Jamal; Djouina, Madjid; Renault, Nicolas; Chavatte, Philippe; Desreumaux, Pierre; Lambert, Didier M.; Millet, Regis; Bioorganic and Medicinal Chemistry; vol. 19; 12; (2011); p. 3777 – 3786;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1188032-12-3,5-(3-Fluorophenyl)isoxazole-3-carboxylic acid,as a common compound, the synthetic route is as follows.

1188032-12-3, Example 126 Synthesis of 5-(3-Fluoro-phenyl)-isoxazole-3-carboxylic acid {2-oxo-2-[4-(3-trifluoromethyl-phenoxy)-piperidin-1-yl]-ethyl}-amide DIPEA (131 mg, 1.0 mmol) was added to a stirred solution of 5-(3-fluoro-phenyl)-isoxazole-3-carboxylic acid (60 mg, 0.29 mmol) (prepared by the method used for the synthesis of Intermediate 25, starting from 3′-fluoroacetophenone) in DMF (2 mL) followed by HOBt (41 mg, 0.3 mmol) and EDCI.HCl (58 mg, 0.3 mmol). After 2 minutes 2-amino-1-[4-(3-trifluoromethyl-phenoxy)-piperidin-1-yl]-ethanone hydrochloride (125 mg, 0.37 mmol) (prepared according to Step 1 and 5 of the General Scheme) was added to the reaction mixture and stirring was continued at ambient temperature overnight. The reaction mixture was diluted with cold water, extracted with ethyl acetate, dried over sodium sulfate and concentrated under reduced pressure. Purification by recrystallisation from methanol afforded 84 mg (59.15% Yield) of 5-(3-fluoro-phenyl)-isoxazole-3-carboxylic acid {2-oxo-2-[4-(3-trifluoromethyl-phenoxy)-piperidin-1-yl]-ethyl}-amide. LC/MS [M+H]+: 492, 70.25%. 1H NMR (300 MHz, DMSO-d6): delta8.6 (t, 1H), 7.8 (m, 2H), 7.5 (m, 3H), 7.24 (m, 4H), 4.7 (m, 1H), 4.2 (d, 2H), 3.9 (m, 1H), 3.7 (m, 1H), 3.4 (m, 2H), 2.0 (m, 2H), 1.6 (m, 2H).

1188032-12-3 5-(3-Fluorophenyl)isoxazole-3-carboxylic acid 66591590, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Forest Laboratories Holdings Limited; US2009/239810; (2009); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1018297-63-6,(3-(4-Fluorophenyl)-5-methylisoxazol-4-yl)methanol,as a common compound, the synthetic route is as follows.

4.98 g (24.0 mmol) of [3-(4-fluorophenyl)-5-methyl-1 ,2-oxazol-4-yl]methanol (WO 2013/057123 A1 , Hoffmann-La Roche) was dissolved in 80 ml_ of anhydrous dichloromethane, and 9.76 g (3.39 ml_, 36.1 mmol) of phosphorus tribromide was added dropwise to the stirred solution. The reaction mixture was stirred for 1 hour at room temeprature, and poured into 50 ml_ of saturated sodium bicarbonate solution. The mixture was stirred for another 10 minutes, and the phases were separated. The organic phase was washed with water, dried over anhydrous sodium sulfate, and evaporated to afford 5.89 g (97%) of the title compound as a yellow-brownish solid. MS (ESI) m/z: 269.9 [M+H]+., 1018297-63-6

1018297-63-6 (3-(4-Fluorophenyl)-5-methylisoxazol-4-yl)methanol 28473136, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; RICHTER GEDEON NYRT.; SZABO, Gyoergy; TUROS, Gyoergy Istvan; ELIAS, Oliver; KAROLYI, Benedek Imre; ERDELYI, Peter; KAPUS, Gabor Laszlo; (75 pag.)WO2020/65597; (2020); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem