Tag: M.W=150-200

Poomathi, Nataraj published the artcileBronsted acid catalysed eco friendly synthesis of quaternary centred C-3 functionalized oxindole derivatives, Recommanded Product: 3-Phenylisoxazol-5(2H)-one, the publication is New Journal of Chemistry (2018), 42(18), 14817-14826, database is CAplus.

A facile atom economic and eco friendly protocol for the synthesis of biol. important quaternary centered C-3 functionalized oxindole derivatives, with a novel nucleus, in high yields was demonstrated by employing 3-hydroxy-2-oxindole, isoxazolone/pyrazolone and environmentally benevolent p-toluene sulfonic acid as a catalyst. The advantages of this protocol were wide substrate scope, practical simplicity, benign solvent and good yields. All the synthesized compounds were evaluated for their in-vitro anti-microbial activity. Several compounds exhibited good activities comparable to those of established standard drugs. Furthermore, the anti-cancer activity of compounds I [R = 5-Cl, , R¹ = H, R² = 5-Br, R = 5-Cl, , R¹ = Ph, R² = H] were preliminarly demonstrated by in-vitro evaluation against human tumor cell lines MCF-7 and Hep-2, using MTT-based assays with com. available standard drug cisplatin as a pos. control. Gratifyingly, compounds I [R = 5-Cl, , R¹ = H, R² = 5-Br, R = 5-Cl, , R¹ = Ph, R² = H] exhibited good in vitro inhibitory activities against Hep-2 and MCF-7 cell lines. These results indicate that 3-indolyl oxindole substituted isoxazole analogs may be potential lead compounds for further biol. screening.

New Journal of Chemistry published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, Recommanded Product: 3-Phenylisoxazol-5(2H)-one.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Yadav, Anubha published the artcileLewis-Base-Catalyzed Domino Reaction of Morita-Baylis-Hillman Carbonates of Isatins with Enolizable Cyclic Carbonyl Compounds: Stereoselective Access to Spirooxindole-Pyrans, Category: isoxazole, the publication is Asian Journal of Organic Chemistry (2018), 7(8), 1595-1599, database is CAplus.

An efficient, organocatalytic, environmentally friendly and stereoselective [3+3] one-pot allylic alkylation/oxa-Michael reaction of a wide range of Morita-Baylis-Hillman carbonates I (R¹ = H, 5-Cl, 5-F, 5,7-Br₂, 5-Me, 5-O₂N; R² = Me, Et, H₂C:CHCH₂, HCCCH₂, Boc, PhCH₂; R³ = EtO₂C, CN) with pharmacol. attractive enolizable C-H activated cyclic carbonyl compounds, such as pyrazolones II (R⁴ = Ph, 4-FC₆H₄, 4-ClC₆H₄, 4-NCC₆H₄; R⁵ = Me, Ph, 4-MeC₆H₄), isoxazolones, 4-hydroxycoumarins, 4-hydroxy-6-methyl-α-pyrone, lawsone and dimedone in a biomass-derived 2-MeTHF as green solvent catalyzed by DABCO as a solid Lewis-base catalyst is reported. This protocol delivers a unique class of medicinally promising spirooxindole-fused-dihydropyran scaffolds, e.g. III.

Asian Journal of Organic Chemistry published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C15H10O2, Category: isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Attanasi, Orazio A. published the artcileInvestigation on the reactivity of isoxazol-5-ones towards 1,2-diaza-1,3-dienes: new entry to variously substituted (imidazol-2-yl)acetate and 1,3-oxazin-6-one derivatives, SDS of cas: 1076-59-1, the publication is Tetrahedron (2012), 68(2), 608-613, database is CAplus.

1,2-Diaza-1,3-dienes (DDs) undergo, under neutral conditions, N-nucleophilic attack from a 4-ethoxycarbonylisoxazol-5-one derivative The first aza-Michael addition is followed by an intramol. second, affording a fused heterobicyclic system that, upon ring opening and decarboxylation processes, gives rise to novel substituted imidazoles e. g., I with an acetate functionality in the 2-position. On the contrary, under the same reaction conditions, 3-phenylisoxazol-5-one provides a double Michael addition at two units of DD involving first the C-4 and then the N-2 of the heterocycle. The resulting diadduct spontaneously undergoes ring-opening/ring-closing process that concludes with a ring enlargement of the heterocycle providing the 1,3-oxazin-6-one deriv II(R¹ = CO₂Me, R² =Ph, Me, 4-NO₂-C₆H₄; R¹ = CO₂tBu,CONHPh, R² = Ph).

Tetrahedron published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, SDS of cas: 1076-59-1.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem