91252-54-9, Ethyl 5-(tert-butyl)isoxazole-3-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Synthesis of 5-tert-butyl-isoxazole-3-carboxylic acid (58) A solution of tert-butyl-substituted isoxazole ethyl ester (54) (2.97 g, 15.1 mmol) in ethanol (30 mL) was stirred at room temperature. To this solution was added a 2M NaOH solution (11.3 mL, 22.6 mmol). After 5 min., TLC showed a complete reaction. To the reaction mixture was added 0.5M HCl to adjust the pH to 3-4 before extracting with ethyl acetate (2¡Á75 mL). The organic extracts were combined, washed with brine, dried over sodium sulfate, and concentrated to afford 5-tert-butyl-isoxazole-3-carboxylic acid (58) as a colorless oil (1.54 g; 94%). 58: 1H NMR (500 MHz, CDCl3): delta 6.44 (s, 1H), 1.39 (s, 9H).
The synthetic route of 91252-54-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Mioskowski, Charles; Marin, Sandra De Lamo; Maruani, Martine; Gill, Manjinder; US2006/199853; (2006); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem