Tag: 33282-16-5

33282-16-5, 5-(4-Methoxyphenyl)isoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of compound 2 (1 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDCI) (0.21 g, 1.1 mmol) and hydroxybenzotriazole (HOBt) (0.13 g, 1 mmol) in dry acetonitrile (10 mL) was stirred at room temperature for 30 min. Then, tryptamine 3 (0.16 g, 1 mmol) was added to the mixture and the reaction was continued at room temperature for 24 h. After completion of reaction, the solvent was reduced under vacuum at 40 C and the residue was dissolved in dichloromethane (50%) and washed with sodium carbonate (10%). The organic phase was dried over Na2SO4 and the solvent was evaporated. The obtained compound 4a-k was completely pure., 33282-16-5

As the paragraph descriping shows that 33282-16-5 is playing an increasingly important role.

Reference£º
Article; Vafadarnejad, Fahimeh; Saeedi, Mina; Mahdavi, Mohammad; Rafinejad, Ali; Karimpour-Razkenari, Elahe; Sameem, Bilqees; Khanavi, Mahnaz; Akbarzadeh, Tahmineh; Letters in drug design and discovery; vol. 14; 6; (2017); p. 712 – 717;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33282-16-5,5-(4-Methoxyphenyl)isoxazole-3-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: A solution of isoxazole acid derivative 1 (1mmol), EDCI (1.1mmol), and HOBt (1mmol) in dry acetonitrile (10mL) was stirred at room temperature for 30min. Then, 3-picolylamine 2a or 4-picolylamine 2b (1mmol) was added drop wise to the mixture and the reaction was continued at room temperature for 24h. After completion of the reaction, the solvent was reduced under vacuum and the residue was dissolved in dichloromethane and washed with sodium carbonate (10%, 3¡Á20). The organic phase was dried over Na2SO4 and the solvent was evaporated under vacuum to give compound 3 which was completely pure. Finally, the mixture of compound 3 (1mmol) and benzyl halide derivative 4 (1.2mmol) in dry acetonitrile (10mL) was heated at reflux for 10-15h. After completion of the reaction which was monitored by TLC, the mixture was allowed to be cool and the precipitates were filtered off to afford products 5a-q in good yields.

The synthetic route of 33282-16-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Vafadarnejad, Fahimeh; Karimpour-Razkenari, Elahe; Sameem, Bilqees; Saeedi, Mina; Firuzi, Omidreza; Edraki, Najmeh; Mahdavi, Mohammad; Akbarzadeh, Tahmineh; Bioorganic Chemistry; vol. 92; (2019);,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem