With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3209-70-9,Ethyl isoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.,3209-70-9
(i) The preparation of 3-aminomethylisoxazole is described below: Di-isobutylaluminium hydride (1.5M in toluene, 29 ml) was added to a solution of ethyl isoxazole-3-carboxylate (6.1 g; Can. J. Chem., 1970, 48, 475) in toluene (20 ml) which was cooled in an ice-bath. The mixture was stirred at laboratory temperature for 16 hours. The analysis indicated that the reduction was incomplete. A second portion of di-isobutylaluminium hydride (28.8 ml) was added and the mixture was stirred for 16 hours. The bulk of the toluene was evaporated and the mixture was poured into a saturated aqueous ammonium chloride solution. The precipitate was filtered off and dried. There was thus obtained 3-hydroxymethylisoxazole (2.1 g).
The synthetic route of 3209-70-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Imperial Chemical Industries PLC; National Research Development Corporation; US5089499; (1992); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem