181696-35-5, 4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The compound of the formula 2 obtained by the filtration in the previous step was added to 50 ml of ethyl acetate and stirred to dissolve;After dissolution, add 48 ml (705.9 mmol, 10e.q) of ammonia water.After reacting at room temperature for 30 min, the aqueous layer was separated, and the organic layer was concentrated and evaporated.Add 25 ml of absolute ethanol to reflux for 30 minutes, cool to room temperature (15 ~ 30 C), and let stand for 10-15 h.Filter and collect the filter cake. Vacuum drying at 55¡À5C, vacuum degree -0.070-0.082Mpa for 4-6h,That is, 16.0 g of valdecoxib (formula 3 compound) was obtained, and the molar yield was 72.6%, and the purity was 99.9% by HPLC., 181696-35-5
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Reference£º
Patent; Kunyao Group Co., Ltd.; Xi Liang; Zhu Changcheng; Jin Yi; Ba Dewei; Wen Na; Hu Yanchao; (12 pag.)CN110256370; (2019); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem