Heterocyclic Building Blocks-isoxazole

1228689-61-9, Methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[00478] Step 4: 5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid[00479] Lithium hydroxide (2g, 48mmol) was added to a solution of 5-(4-bromo-phenyl)-3-methyl- isoxazole-4-carboxylic acid methyl ester (39mmol) in methanol (50mL) and water (lOmL), and the reaction was stirred at 60C for 1 hour. Acidic work-up gave the title compound.

1228689-61-9, The synthetic route of 1228689-61-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMIDRA PHARMACEUTICALS, INC.; BRITTAIN, Jason, Edward; SEIDERS, Thomas, Jon; KING, Christopher, David; WO2011/159550; (2011); A2;,
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62348-13-4,62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of the corresponding acyl chloride (9.18 mmol) in chloroform (25 mL) was slowly added dropwise to a stirred solution of methyl imidoselenocarbamate hydroiodide (4.59 mmol) in dry chloroform (40 mL) and pyridine (5 mL). The mixture was stirred for 48 h at room temperature. Solvents were removed under vacuum by rotatory evaporation and the residue was treated with water (100 mL) and purified as indicated in Table 1. The spectroscopic data are shown in Table 2.

The synthetic route of 62348-13-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Font, Maria; Lizarraga, Elena; Ibanez, Elena; Plano, Daniel; Sanmarti?, Carmen; Palop, Juan A.; European Journal of Medicinal Chemistry; vol. 66; (2013); p. 489 – 498;,
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51135-73-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51135-73-0,Ethyl 5-methylisoxazole-4-carboxylate,as a common compound, the synthetic route is as follows.

(iii) 5-Methylisoxazol-4-yl carboxylic acid Ethyl 5-methylisoxazol-4-yl carboxylate (65 g) was heated under reflux in 10M HCl (500 ml) for 3 hours. On cooling the product crystallized out. This was filtered and dried giving 42 g of a white crystalline solid, m.p. 134-136 C.

51135-73-0 Ethyl 5-methylisoxazole-4-carboxylate 7009317, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Lilly Industries Limited; US4892963; (1990); A;,
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10558-25-5, 4-Bromo-3,5-dimethylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-bromo-3,5-dimethylisoxazole (1.0 equiv.), 3,5-difluorophenylboronic acid (1.3 equiv.), and PdCl2(dppf).CH2Cl2 adduct (0.1 equiv.) were combined in a microwave vial and 1,4-Dioxane (0.3 M) was added followed by 2M sodium carbonate (2.0 equiv.). The mixture was purged with N2, sealed and heated at 120 C. for 40 min in the microwave. The mixture was partitioned between EtOAc and brine. The organic layer was dried over sodium sulfate, filtered and concentrated to afford a black solid. The crude black material was purified by ISCO SiO2 chromatography eluting with 0-100% DCM in Heptanes to afford 4-(3,5-difluorophenyl)-3,5-dimethylisoxazole in 60% yield. LC/MS (m/z): 210.1 (MH+), Rt=0.88 min. 1H NMR (400 MHz, ) delta 6.73-6.87 (m, 3H), 2.43 (s, 3H), 2.29 (s, 3H).

10558-25-5, The synthetic route of 10558-25-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Burger, Matthew; Ding, Yu; Han, Wooseok; Nishiguchi, Gisele; Rico, Alice; Simmons, Robert Lowell; Smith, Aaron R.; Tamez, JR., Victoriano; Tanner, Huw; Wan, Lifeng; US2012/225061; (2012); A1;,
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7063-99-2, Ethyl 5-phenylisoxazole-3-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,7063-99-2

10298] Acetophenone (3 g, 25 mmol) was taken up in 30 mE of dry toluene and NaR (780 mg, 32 mmol) was then added. The resulting reaction mixture was stirred at room temperature for 60 minutes. A solution of diethyl oxalate (5.5 g, 37.5 mmol) in dry toluene (25 mE) was then added drop wise and stirred at room temperature for 1 hout The reaction mixture was concentrated under reduced pressure and the resulting residue was diluted with ice watet The precipitated solids were collected by filtration and dried to afford 2.85 g of ethyl 2,4-dioxo-4-phenylbutanoate (52% yield) as a yellow solid. This material (2.85 g, 12.9 mmol) was taken up in EtOR (25 mE) along with NH2OH.HC1 (1.16 g, 16.8 mmol) and then stirred under reflux for 3 hours. The reaction mixture was concentrated under reduced presresulting sure. The resulting residue was diluted with water and extracted with EtOAc. The combined organic layers were washed with H20, dried (Na2SO4) and concentrated under reduced pressure. Purification by silica gel chromatography (pentanes/EtOAc) afforded ethyl 5-phenylisoxazole-3-car- boxylate (2.53 g, 90% yield) as a white solid. This material (2.53 g, 11.6 mmol) was taken up in THF/H20 (45 mE/S mE) along with EiOH.H20 (1.0 g, 23.3 mmol) and thereaction mixture was stirred at room temperature for 2 hours. The reaction mixture was then concentrated under reduced pressure. Sufficient 1 N HC1 was added to the resulting residue to bring the pH to about 5. The resulting solids were collected by filtration and dried under high vacuum to afford 1.5 g of 5-phenylisoxazole-3-carboxylic acid (69%) as a white solid. 5-Phenylisoxazole-3-carboxylic acid was then coupled with (4Z,7Z,10Z,13Z,16Z,19Z)- N-((R)-1 -amino-3-(((R)-3-amino-4-((1 ,3-dihydroxypro- pan-2-yl)amino)-2-methyl-4-oxobutan-2-yl)disulfanyl)-1 – oxopropan-2-yl)docosa-4,7, 10,13,16,1 9-hexaenamide using the same amide coupling procedure as detailed in example 4. The final product was purified by silica gel chromatography (CH2C12/MeOH). MS, calculated for C43H59N50752:821.39; found 822 [M+H].

7063-99-2 Ethyl 5-phenylisoxazole-3-carboxylate 571142, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Catabasis Pharmaceuticals, Inc.; Vu, Chi B.; (90 pag.)US2017/342046; (2017); A1;,
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108655-63-6, 3-(Trifluoromethyl)isoxazol-5-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 1 3-Trifluoromethyl-5-hydroxyisoxazole A solution of 36% HCl (9.12 g, 15 eq.) and n-propanol (9.0 ml) was added to 5-amino-3-trifluoromethylisoxazole (0.91 g, 6.0 mmole) from Preparation 1 and heated at reflux for 23 hours. The reaction mixture was cooled, extracted with methylene chloride and distilled under reduced pressure to give 0.006 g (0.7%) of the titled compound as a colorless liquid, b.p. 35-37 C./1.4 mmHg., 108655-63-6

The synthetic route of 108655-63-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shionogi & Co., Ltd.; US5082947; (1992); A;,
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62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62348-13-4, Example 189-329 The general method described in Examples 74-113 was used to treat 9,10, 11,12- tetrahydro-8H-[1, 4] diazepino [l’, 2′ : 1,2] imidazo [4,5-c] quinolin-6-amine hydrochloride (32.5 mg, 0.100 mmol) with N, N diisopropylethylamine (0.0525 mL, 0.30 mmol) and the reagent (0.108 mmol) indicated in the table below. The compounds were purified by prep HPLC using the method described above. The table below shows the acid chloride, sulfonyl chloride, isocyanate, carbamoyl chloride, or sulfamoyl chloride used for each example, the structure of the resulting compound, and the observed accurate mass for the isolated trifluoroacetate salt.

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Patent; 3M INNOVATIVE PROPERTIES COMPANY; WO2005/66172; (2005); A1;,
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123770-62-7, Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 376 ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate (50.0 mg, 0.29 mmol) in 311 DCM (2 mL) was added 378 diethylaminosulfur trifluoride (70.6 mg, 0.06 ml, 0.44 mmol). The mixture was stirred at 40 C. for 1 hour. 55 Water (3 mL) was added and the mixture was extracted with ethyl acetate (5 mL¡Á3). The combined organic layers were washed with brine (5 mL), dried over Na2SO4 and concentrated. The crude mixture was purified by flash chromatography with heptane:ethyl acetate=1:0 to 0:1 to give 379 ethyl 5-(fluoromethyl)isoxazole-3-carboxylate (41.0 mg).

123770-62-7, As the paragraph descriping shows that 123770-62-7 is playing an increasingly important role.

Reference£º
Patent; H. Lundbeck A/S; Juhl, Karsten; Jessing, Mikkel; Langgard, Morten; Vital, Paulo Jorge Vieira; Kehler, Jan; Rasmussen, Lars Kyhn; Clementson, Carl Martin Sebastian; Marigo, Mauro; (154 pag.)US2019/194189; (2019); A1;,
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16401-14-2, Isoxazole-5-carbaldehyde is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 91 7-Bromo-2-isoxazol-5-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine The title compound, MS m/e (%): 280 (M+, 100), was prepared in accordance with the general method of example 63 from 4-bromo-pyridine-2,6-diamine, O-mesitylene-sulfonylhydroxylamine, and isoxazole-5-carbaldehyde. The purification was performed with reversed phase HPLC eluting with an acetonitrile/water gradient.

16401-14-2, As the paragraph descriping shows that 16401-14-2 is playing an increasingly important role.

Reference£º
Patent; Hoffmann-La Roche Inc.; US6355653; (2002); B1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2510-36-3,3,5-Dimethylisoxasole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

2-(2-(3,5-dimethylisoxazole-4-carbonyl)benzofuran-5-yl)-N-((2,4-dimethylphenyl)(phenyl)methyl) acetamidea) methyl 3,5-dimethylisoxazol -4-carboxylateTo a solution of 3,5-dimethylisoxazole-4-carboxylic acid (9.2 g, 65.2 mmol) in MeOH (50 mL) was added SOCI2 (15.3 g, 130.4 mmol) very slowly. The reaction mixture was heated to 70 C overnight. The reaction mixture was then cooled to rt, concentrated, and purified by column chromatography (10% EtO Ac/petroleum ether) to afford the title compound (9.0 g, 89%). LCMS- Pl : 156 [M+H]+; Rt: 1.404 min., 2510-36-3

As the paragraph descriping shows that 2510-36-3 is playing an increasingly important role.

Reference£º
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard; WO2013/19682; (2013); A1;,
Isoxazole – Wikipedia
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