Heterocyclic Building Blocks-isoxazole

Proton spin-spin coupling constants in isothiazole, isoxazole, and some of their alkyl derivatives was written by Wasylishen, Roderick E.;Rowbotham, J. Brian;Schaefer, Ted. And the article was included in Canadian Journal of Chemistry in 1974.Computed Properties of C4H5NO This article mentions the following:

The signs and magnitudes of the spin-spin coupling constants over three to six bonds between protons in isothiazole, isoxazole, and in 10 of their alkyl derivatives are discussed in terms of the coupling mechanisms. The chem. shifts of ring protons and Me protons arise from a common mechanism originating in the ring but are not simply related to electron ds. calculated by MO theory at the CNDO/2 level of approximation In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6Computed Properties of C4H5NO).

5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. Isoxazoles are aromatic heterocycles containing an N–O bond. The weakness of this bond allows the ring opening of these heterocycles under reductive conditions. Isoxazole can be synthesised via a variety of methods. Examples include via a 1,3-dipolar cycloaddition of nitrile oxides with alkynes.Computed Properties of C4H5NO

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Relationship between CYP2D6 genotype, activity score and phenotype in a pediatric Thai population treated with risperidone was written by Hongkaew, Yaowaluck;Gaedigk, Andrea;Wilffert, Bob;Ngamsamut, Nattawat;Kittitharaphan, Wiranpat;Limsila, Penkhae;Sukasem, Chonlaphat. And the article was included in Scientific Reports in 2021.Formula: C23H27FN4O3 This article mentions the following:

Recently, the Clin. Pharmacogenetics Implementation Consortium (CPIC) have revised recommendations for the translation of CYP2D6 genotype to phenotype. Changes affect phenotype grouping, as well as the value used to calculate activity score for the CYP2D6*10 allele to better reflect the substantially decreased activity of this allele which is the most frequent allele found in Asian populations. This study aimed to evaluate whether the lower value for CYP2D6*10 as recommended, and the revised phenotype groupings improve the relationship between CYP2D6 genotype and risperidone measures. One hundred and ninety-nine children and adolescents with autism treated with a risperidone-based regimen for at least four weeks were included. CYP2D6 genotype was determined using the Luminex xTAG CYP2D6 Kit assay and translated into phenotype using different translation methods. Plasma concentrations of risperidone and 9-hydroxyrisperidone were measured using LC/MS/MS. Plasma levels of risperidone, risperidone concentration/dose ratio, and risperidone/9-hydroxyrisperidone ratio in patients with an activity score < 1 were significantly higher than those ≥ 1 (P value < 0.001 for all three parameters). Plasma risperidone levels and risperidone concentration/dose ratios were significantly higher in intermediate metabolizers (defined as AS = 0.25-0.75) than normal metabolizer (defined as AS = 1-2) patients (1.44 vs. 0.23 ng/mL, P < 0.001 and 1.63 vs. 0.29 ng/mL/ng, P < 0.001, resp.) as well as risperidone/9-hydroxyrisperidone ratio (0.20 vs. 0.04, P < 0.001). This is the first study in an Asian population utilizing the revised CPIC-recommended method for translating the CYP2D6 genotype to phenotype. In addition to validating that CYP2D6 genetic variation significantly impacts risperidone metabolism, we demonstrated that revised value for the CYP2D6*10 was superior for genotype to phenotype translation. However, at least for risperidone, subjects with an activity score of 1 presented as phenotypic normal, and not intermediate metabolizers, suggesting that phenotype classification is substrate dependent. In the experiment, the researchers used many compounds, for example, 3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (cas: 144598-75-4Formula: C23H27FN4O3).

3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (cas: 144598-75-4) belongs to isoxazole derivatives. Isoxazoles are aromatic heterocycles containing an N–O bond. The weakness of this bond allows the ring opening of these heterocycles under reductive conditions. Isoxazole can be synthesised via a variety of methods. Examples include via a 1,3-dipolar cycloaddition of nitrile oxides with alkynes.Formula: C23H27FN4O3

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Paliperidone Extended Release Versus Olanzapine in Treatment-Resistant Schizophrenia: A Randomized, Double-Blind, Multicenter Study was written by Wang, Dandan;Wei, Ning;Hu, Fangzhen;Li, Jianhua;Wang, Yucheng;Qian, Zhiwei;Yang, Miao;Yao, Mingrong;Xia, Yong;Yu, Hong;Tu, Wenzhen;Ye, Minjie;Qian, Cheng;Hu, Jianbo;Chen, Jingkai;Hu, Chanchan;Huang, Manli;Xu, Yi;Hu, Shaohua. And the article was included in Journal of Clinical Psychopharmacology in 2022.Application In Synthesis of 3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one This article mentions the following:

Paliperidone is an atypical antipsychotic as effective as other atypical antipsychotics for schizophrenia. However, few studies have explored the efficacy of paliperidone for treatment-resistant schizophrenia. This study aimed to compare the efficacy and safety of paliperidone extended release (ER) vs. olanzapine in schizophrenia patients with either poor treatment response or intolerable adverse effects due to standardized antipsychotic therapy. This 12-wk randomized, double-blind, multicenter study compared the treatment efficacy on psychotic symptoms, cognitive functions, and tolerance between paliperidone ER (6-15 mg/d, n = 45) and olanzapine (10-30 mg/d, n = 41) in treatment-resistant or treatment-intolerant patients with schizophrenia. The severity of psychotic symptoms was evaluated by the Pos. and Neg. Syndrome Scale and the Clin. Global Impression Severity of Illness Scale. The cognitive functions were assessed by the MATRICS Consensus Cognitive Battery. In addition, the metabolic impacts were evaluated by weight gain and waist circumference. Patients with either paliperidone ER or olanzapine treatment showed apparent improvement in psychotic symptoms, without significant intergroup difference. Twelve-week paliperidone ER or olanzapine treatment did not improve the cognitive functions. Both paliperidone ER and olanzapine treatment caused significant increase in weight and waist circumference, and olanzapine had a greater impact on waist circumference than paliperidone ER. In addition, both drugs were well tolerated. Paliperidone ER could be a safe alternative for treatment-resistant schizophrenia. In the experiment, the researchers used many compounds, for example, 3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (cas: 144598-75-4Application In Synthesis of 3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one).

3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (cas: 144598-75-4) belongs to isoxazole derivatives. Isoxazoles are aromatic heterocycles containing an N–O bond. Isoxazoles are commonly used as enaminoketone or β-diketone surrogate. Some alternative routes for the synthesis of isoxazoles have also been developed and reported. The 2-benzoyl-2-halo-2H-azirines provide 4-haloisoxazoles in good yields after heating in toluene at reflux temperature.Application In Synthesis of 3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Preparation of β-oxo nitriles through acylation of trimethylsilyl cyanoacetate by mixed anhydrides was written by Goasdoue, Claude;Couffignal, Rene. And the article was included in Tetrahedron Letters in 1979.SDS of cas: 5765-44-6 This article mentions the following:

Treating Me₃SiO₂CCHLiCN (I) and EtCHLiCN with RCO₂CO₂Et (R = Pr, Ph) gave 59 and 74% RCOCH₂CN, and 55 and 74% RCOCHEtCN, resp. I was prepared by treating HO₂CCH₂CN with Me₃SiCl (90%) followed by lithiation. In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6SDS of cas: 5765-44-6).

5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. Isoxazole are described as inhibitors of acetylcholinesterase (AChE). Isoxazole ligands bind to and inhibit the Sxc- antiporter. Isoxazoles are potent isosteres of pyridine and have been found to inhibit voltage-gated sodium channels for pain control, for the construction of tetracycline antibiotic derivatives, and as a therapeutic agent for depression.SDS of cas: 5765-44-6

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Development of antiinflammatory agents. I. Isoxazole derivatives was written by Park, No Sang;Kim, Hyun Sook;Min, Changhee;Choi, Joong Kwon. And the article was included in Yakhak Hoechi in 1990.Application In Synthesis of 3-(Trifluoromethyl)isoxazol-5-amine This article mentions the following:

3-Substituted 5-aminoisoxazole-4-carboxylates I (R = CF₃, CHF₂, Ph, 4-MeOC₆H₄, 2-, 3-, or 4-R¹C₆H₄; R¹ = F, Cl, CF₃, NO₂; R² = Me) were prepared by the reaction of corresponding bromoaldoximes with cyanoacetate. I (R = CF₃, R² = Me) (II) was acylated with various aminopyridine derivatives to afford diamides. The ester group of II was hydrolyzed and decarboxylated easily to give 3-trifluoromethyl-5-aminoisoxazole. The aminoisooxazole was also converted to amides. The synthesized compounds were tested for antiinflammatory activities. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)isoxazol-5-amine (cas: 108655-63-6Application In Synthesis of 3-(Trifluoromethyl)isoxazol-5-amine).

3-(Trifluoromethyl)isoxazol-5-amine (cas: 108655-63-6) belongs to isoxazole derivatives. Isoxazoles present in various natural products and synthetic compounds of biological importance like antibacterial, antagonists, antiinflammatory, analgesics, and also show the applications in functional materials. The electrophilic cyclization of various 2-alkynone O-methyl oximes with a wide range of substrates such as ICl, I2, Br2, PhSeBr, etc. provides a variety of 3,4,5-trisubstituted isoxazoles in good to excellent yields.Application In Synthesis of 3-(Trifluoromethyl)isoxazol-5-amine

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Acetylenic compounds, XLIV. Synthesis of 3-aminoisoxazoles and 3-hydroxyisoxazoles (3-isoxazolones) was written by Iwai, Issei;Nakamura, Norio. And the article was included in Chemical & Pharmaceutical Bulletin in 1966.Recommanded Product: 14678-05-8 This article mentions the following:

A solution of β,4-dibromocinnamonitrile (0.0028 mole) in 10 ml. EtOH was mixed with NH2OH.HCl (0.016 mole) in 10 ml. 10% NaOH. After standing overnight, the mixture was extracted with ether. The ethereal layer was extracted with 10% HCl solution After neutralization with aqueous NaOH, yellow precipitate was taken up in ether. After evaporation of the solvent, the residue was crystallized from aqueous MeOH to yield 57% yellow 3-amino-5-(p-bromophenyl)isoxazole (I), m. 147-9°. To a solution of 12.2 g. ClCN in 150 ml. absolute ether was added a solution of Grignard reagent prepared from p-methoxyphenylpropiolonitrile (II), m. 78.5-80°. To a mixture of 0.018 mole NH2OH.HCl and 0.062 mole 10% NaOH was added a solution of 0.006 mole (II) in 25 ml. EtOH. After standing overnight the mixture was extracted with ether to give 41% 3-amino-5-(p-methoxyphenyl)isoxazole (III), m. 171-2°. Similarly prepared was 3-methyl-5-aminoisoxazole (IV) m. 84-5°, 3:1 mixture of 3-amino-5-phenylisoxazole and IV, 3-sulfanilamido-5-methylisoxazole, m. 166-7°, 5-aminoisoxazole, m. 75-7°, 5-benzamidoisoxazole, m. 134-5° (62% yield), 3 aminoisoxazole, b. 75-6°, 3-benzamidoisoxazole, m. 148-9°, 3-acetylsulfanilamidoisoxazole, m. 245-7° (decomposition), 3-sulfanilamidoisoxazole, m. 124-6°, 3-hydroxy-5-phenylisoxazole, m. 163-5°, 3-hydroxy-5-(p-nitrophenyl)isoxazole, m. 232-4° (decomposition), 3-hydroxy-5-(p-chlorophenyl)isoxazole, m. 220-1° (decomposition), 3-hydroxy-5-(p-methoxyphenyl)isoxazole, m. 212-14° (decomposition), 3-hydroxy-5-methylisoxazole, m. 84-5°, 3-hydroxyisoxazole, m. 98-9°, 3-phenyl-5-isoxazolone, m. 151-2°. In the experiment, the researchers used many compounds, for example, Isoxazol-5-amine (cas: 14678-05-8Recommanded Product: 14678-05-8).

Isoxazol-5-amine (cas: 14678-05-8) belongs to isoxazole derivatives. Isoxazoles present in various natural products and synthetic compounds of biological importance like antibacterial, antagonists, antiinflammatory, analgesics, and also show the applications in functional materials. Some alternative routes for the synthesis of isoxazoles have also been developed and reported. The 2-benzoyl-2-halo-2H-azirines provide 4-haloisoxazoles in good yields after heating in toluene at reflux temperature.Recommanded Product: 14678-05-8

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

2,2,2-Trichloroethyl Aryldiazoacetates as Robust Reagents for the Enantioselective C-H Functionalization of Methyl Ethers was written by Guptill, David M.;Davies, Huw M. L.. And the article was included in Journal of the American Chemical Society in 2014.Category: isoxazole This article mentions the following:

A new class of reagents is described for C-H functionalization by means of C-H insertion using donor/acceptor-substituted rhodium(II) carbene intermediates. The 2,2,2-trichloroethyl aryl and heteroaryl diazoacetates, together with the dirhodium triarylcyclopropane carboxylate catalyst Rh₂(R-BPCP)₄, enabled the enantioselective intermol. C-H functionalization of a range of Me ethers with high levels of site selectivity and enantioselectivity. In the experiment, the researchers used many compounds, for example, 3-Methylisoxazole-5-acetic Acid (cas: 19668-85-0Category: isoxazole).

3-Methylisoxazole-5-acetic Acid (cas: 19668-85-0) belongs to isoxazole derivatives. Isoxazoles are aromatic heterocycles containing an N–O bond. Isoxazoles are commonly used as enaminoketone or β-diketone surrogate. Isoxazole can be synthesised via a variety of methods. Examples include via a 1,3-dipolar cycloaddition of nitrile oxides with alkynes.Category: isoxazole

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Aromatic compounds of Sinkiang thick-skinned melons storaged in different conditions by method of solid phase micro-extraction was written by Chen, Cunkun;Wang, Wensheng;Feng, Jiongqi;Dong, Chenghu;Gao, Yuanhui. And the article was included in Shipin Gongye Keji in 2008.Recommanded Product: 14678-05-8 This article mentions the following:

The aromatic compounds of the thick-skinned melon “Golden Phoenix” were detected by combining solid phase micro-extraction with GC-MS method. The “Golden Phoenix” melons were stored in two different conditions (CA conditions: temperature 6±0.5°C, O₂ 4%-6%, CO₂ 0.2%-0.5%, and ozone storage conditions: 0.45 μL/L ozone for 3 min every 48 h). More 30 volatile compounds of thick-skinned melons were detected after they were stored for 52 d. Of them 20 esters were identified tentatively and their peak areas reached 85.49% with CA storage, and 17 esters were identified tentatively and their peak areas reached 67.15% with ozone storage. The esters were the main aromatic compounds of the thick-skinned melons. The results showed that the compounds and concentrations of the melons stored with the different conditions had significant difference, and the aromatic compounds of the melons could be better maintained in the CA condition than those in the ozone condition. In the experiment, the researchers used many compounds, for example, Isoxazol-5-amine (cas: 14678-05-8Recommanded Product: 14678-05-8).

Isoxazol-5-amine (cas: 14678-05-8) belongs to isoxazole derivatives. Isoxazoles present in various natural products and synthetic compounds of biological importance like antibacterial, antagonists, antiinflammatory, analgesics, and also show the applications in functional materials. The electrophilic cyclization of various 2-alkynone O-methyl oximes with a wide range of substrates such as ICl, I2, Br2, PhSeBr, etc. provides a variety of 3,4,5-trisubstituted isoxazoles in good to excellent yields.Recommanded Product: 14678-05-8

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Antipsychotic Use During Pregnancy and Risk for Gestational Diabetes: A National Register-Based Cohort Study in Sweden was written by Heinonen, Essi;Forsberg, Lisa;Noerby, Ulrika;Wide, Katarina;Kaellen, Karin. And the article was included in CNS Drugs in 2022.Application In Synthesis of 3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one This article mentions the following:

We aimed to study whether antipsychotic use during pregnancy is associated with gestational diabetes. This was a Swedish national register-based cohort study on the Medical Birth Register and the Prescribed Drug Register including all 1,307,487 singleton births between July 2006 and Dec. 2017. Antipsychotics were divided into first-generation antipsychotics (n = 728), high-risk metabolic second-generation antipsychotics including olanzapine, clozapine and quetiapine (n = 1710), and other second-generation antipsychotics (n = 541). The risks for gestational diabetes, fetal growth disturbances, pre-eclampsia, caesarean section and preterm labour were assessed. Women treated during pregnancy were compared to women not treated during pregnancy and to women who used antipsychotics before/after but not during pregnancy. The crude risk ratio for gestational diabetes for women treated with high-risk metabolic second-generation antipsychotics during pregnancy was 2.2 (95% confidence interval [CI] 1.6-2.9) compared to untreated pregnant women (n = 1,296,539) and 1.8 (95% CI 1.4-2.5) compared to women treated before/after pregnancy (n = 34,492). After adjustment for maternal factors including body mass index, the risk ratios were 1.8 (95% CI 1.3-2.4) and 1.6 (95% CI 1.2-2.1). Exposed infants had an increased risk of being large for gestational age: adjusted risk ratios 1.6 (95% CI 1.3-1.9) and 1.3 (95% CI 1.1-1.6) compared to no maternal antipsychotic use during pregnancy and maternal use before/after the pregnancy. Other antipsychotics were not associated with metabolic risks. Olanzapine, clozapine and quetiapine used during pregnancy were associated with increased risks for gestational diabetes and the infant being large for gestational age. Enhanced metabolic monitoring should be considered for pregnant women using these drugs. In the experiment, the researchers used many compounds, for example, 3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (cas: 144598-75-4Application In Synthesis of 3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one).

3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (cas: 144598-75-4) belongs to isoxazole derivatives. Isoxazoles also form the basis for a number of drugs, including the COX-2 inhibitor valdecoxib (Bextra) and a neurotransmitter agonist AMPA. Isoxazole can be synthesised via a variety of methods. Examples include via the reaction of hydroxylamine with 1,3-diketones or derivatives of propiolic acid.Application In Synthesis of 3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

MAP Bayesian modelling combining striatal dopamine receptor occupancy and plasma concentrations to optimize antipsychotic dose regimens in individual patients was written by Ismail, Mohamed;Straubinger, Thomas;Uchida, Hiroyuki;Graff-Guerrero, Ariel;Nakajima, Shinichiro;Suzuki, Takefumi;Caravaggio, Fernando;Gerretsen, Philip;Mamo, David;Mulsant, Benoit H.;Pollock, Bruce G.;Bies, Robert. And the article was included in British Journal of Clinical Pharmacology in 2022.Computed Properties of C23H27FN4O3 This article mentions the following:

Aims : Develop a robust and user-friendly software tool for the prediction of dopamine D2 receptor occupancy (RO) in patients with schizophrenia treated with either olanzapine or risperidone, in order to facilitate clinician exploration of the impact of treatment strategies on RO using sparse plasma concentration measurements. Methods : Previously developed population pharmacokinetic models for olanzapine and risperidone were combined with a pharmacodynamic model for D2 RO and implemented in the R programming language. Maximum a posteriori Bayesian estimation was used to provide predictions of plasma concentration and RO based on sparse concentration sampling. These predictions were then compared to observed plasma concentration and RO. Results : The average (standard deviation) response times of the tools, defined as the time required for the application to predict parameter values and display the output, were 2.8 (3.1) and 5.3 (4.3) seconds for olanzapine and risperidone, resp. The mean error (95% confidence interval) and root mean squared error (95% confidence interval) of predicted vs. observed concentrations were 3.73 ng/mL (-2.42-9.87) and 10.816 ng/mL (6.71-14.93) for olanzapine, and 0.46 ng/mL (-4.56-5.47) and 6.68 ng/mL (3.57-9.78) for risperidone and its active metabolite (9-OH risperidone). Mean error and root mean squared error of RO were -1.47% (-4.65-1.69) and 5.80% (3.89-7.72) for olanzapine and -0.91% (-7.68-5.85) and 8.87% (4.56-13.17) for risperidone. Conclusion : Our monitoring software predicts concentration-time profiles and the corresponding D2 RO from sparsely sampled concentration measurements in an accessible and accurate form. In the experiment, the researchers used many compounds, for example, 3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (cas: 144598-75-4Computed Properties of C23H27FN4O3).

3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (cas: 144598-75-4) belongs to isoxazole derivatives. Isoxazole rings are found in some natural products, such as ibotenic acid and muscimol. Isoxazoles are potent isosteres of pyridine and have been found to inhibit voltage-gated sodium channels for pain control, for the construction of tetracycline antibiotic derivatives, and as a therapeutic agent for depression.Computed Properties of C23H27FN4O3

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem