Category: 51135-73-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51135-73-0,Ethyl 5-methylisoxazole-4-carboxylate,as a common compound, the synthetic route is as follows.

51135-73-0, EXAMPLE 4 Preparation of 5-Methylisoxazole-4-Carboxylic Acid A two-necked flask fitted with mechanical stirrer and a horizontal condenser for distillation was charged with 40.0 g of crude Ethyl-5-methylisoxazole-4-carboxylate and 44 g of 60% sulfuric acid and the mixture was heated to 85 C. with continuous distillation of ethanol from the reaction product. After four hours of heating at 85 C., TLC showed the complete disappearance of the upper spot of ester. The mixture was allowed to cool in the refrigerator and the solid acid was filtered (16.5 g) Filtrate kept at room temperature for second crop. Acid was crystallized in 60 mL 2% acetic acid-Toluene to obtain about 99.9% pure acid (9.5 g). Mother liquor of the final crystallization was kept for second crop. Crystallization was accomplished by: The crude acid was taken in 2% acetic acid-toluene mixture and heated for 30 minutes. Brown oil was separated at the bottom of the flask. The clear organic phase was neatly transferred and kept for crystallization.

The synthetic route of 51135-73-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ray, Anup Kumar; Patel, Hiren Kumar V.; Patel, Mahendra R.; US2003/139606; (2003); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

51135-73-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51135-73-0,Ethyl 5-methylisoxazole-4-carboxylate,as a common compound, the synthetic route is as follows.

(iii) 5-Methylisoxazol-4-yl carboxylic acid Ethyl 5-methylisoxazol-4-yl carboxylate (65 g) was heated under reflux in 10M HCl (500 ml) for 3 hours. On cooling the product crystallized out. This was filtered and dried giving 42 g of a white crystalline solid, m.p. 134-136 C.

51135-73-0 Ethyl 5-methylisoxazole-4-carboxylate 7009317, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Lilly Industries Limited; US4892963; (1990); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

51135-73-0, Ethyl 5-methylisoxazole-4-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,51135-73-0

(iii) 5-Methylisoxazol-4-yl carboxylic acid Ethyl 5-methylisoxazol-4-yl carboxylate (65 g) was heated under reflux in 10 M HCl (500 ml) for 3 hours. On cooling the product crystallized out. This was filtered and dried giving 42 g of a white crystalline solid, m.p. 134-136 C.

As the paragraph descriping shows that 51135-73-0 is playing an increasingly important role.

Reference£º
Patent; Lilly Industries Limited; US4983619; (1991); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

51135-73-0,51135-73-0, Ethyl 5-methylisoxazole-4-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ethyl-5-methylisoxazole-4-carboxylate 7 g (0.045 mol) was heated under reflux in aqueous sulphuric acid (20 % v/v, 30 ml) for 16 hr followed by cooling to room temperature with stirring for 4 h. The crystallized solid product was filtered and washed using toluene followed by water and dried. The product then was crystallized from ethanol to produce 3.5 g (60 %) of 5-Methylisoxazole-4-carboxylic acid as a white solid, mp. 147-148 C (reported mp. 144-147 C).

51135-73-0 Ethyl 5-methylisoxazole-4-carboxylate 7009317, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Article; Hamdi, Abdelrahman; Said, Eman; Farahat, Abdelbasset A.; El-Bialy, Serry A.A.; Massoud, Mohammed A.M.; Letters in drug design and discovery; vol. 13; 9; (2016); p. 912 – 920;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem