Category: 42831-50-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42831-50-5,5-Methylisoxazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

Stage a) 5-Methylisoxazole-4-carboxylic acid (4-aminophenyl)amide 10.1 g (0.08 mol) of 5-methylisoxazole-4-carboxylic acid and 8.65 g (0.08 mol) of p-phenylenediamine are dissolved in 300 ml of tetrahydrofuran and 18.05 g (0.088 mol) of dicyclohexyicarbodiimide are added. After 5 hours (“h”), the deposited precipitate is filtered off with suction, the organic phase is concentrated and the product is chromatographed on silica gel by means of ethyl acetate/petroleum ether with addition of 1% glacial acetic acid and then crystallized from ethyl acetate/petroleum ether. The yield of the process was 6.8 g of acetate salt with a melting point of 123 C. to 128 C.

42831-50-5, As the paragraph descriping shows that 42831-50-5 is playing an increasingly important role.

Reference£º
Patent; Hoechst Aktiengesellschaft; US5977151; (1999); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

42831-50-5, 5-Methylisoxazole-4-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-Methylisoxazole-4-carboxylic acid (1 g, 7.86 mmol) was added to SOCl 2 (3 mL) and stirred at 50 C. After completion of the reaction, the reaction mixture was cooled and then distilled under reduced pressure to remove volatile materials to obtain crude yellow oil (96%)

The synthetic route of 42831-50-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Erica Hanyang University Academic Cooperation; Ha, Jung Mi; Jung, Gyung Jin; (27 pag.)KR2016/34632; (2016); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

42831-50-5, 5-Methylisoxazole-4-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 5: To generate the acid chloride a suspension of 5-methyl-1 ,2-oxazole-4-carboxylic acid (39 mg, 0.30 mmol) in CH2CI2 (0.5 mL) at 0 C was added oxalyl chloride (50 muIota_, 1.2 mmol) and DMF (1 drop). The suspension was allowed to stir for a further 15 min at 0 C followed by 2 h at room temperature. The resulting mixture was concentrated in vacuo to give a dark oil. The oil was twice suspended in n-hexanes (2 x 1 mL) and concentrated in vacuo. A solution of 7-acetyl-10a-(4-chlorophenyl)-2,3, 10, 10a-tetrahydro-1 H,5H-imidazo[1 ,2- a]pyrrolo[1 ,2-c ]pyrazin-5-one (20 mg, 61 muetaetaomicronIota) in pyridine (0.5 mL) was added to a suspension of the acid chloride (generated as above; 0.30 mmol) in pyridine (0.5 mL) and CH2CI2 (0.5 mL) at 0 C . The resultant mixture was warmed to room temperature and stirred for 16 h. The reaction mixture was diluted with a saturated aqueous solution of NaHC03 (25 mL) and extracted with CH2CI2 containing 20% of propan-2-ol (3 x 25 mL). The organic layers were combined, dried and concentrated in vacuo to yield a crude brown residue that was partially purified using flash chromatography (Biotage SP4, 12 g cartridge, 0-10%MeOH gradient in CH2CI2) to give a mixture (10 mg) containing the desired product which was further purified by flash chromatography (2 x Biotage SP4, 12 g cartridge, C18 phase, 20-40% acetonitrile gradient in water) to give 7-acetyl-10a-(4-chlorophenyl)-1-[(5-methyl-1 ,2- oxazol-4-yl)carbonyl]-2,3, 10, 10a-tetrahydro-1 H,5H-imidazo[1 ,2-a]pyrrolo[1 ,2-c ]pyrazin-5-one (24) as a solid (3.5 mg, yield 14%).

As the paragraph descriping shows that 42831-50-5 is playing an increasingly important role.

Reference£º
Patent; BIOTA SCIENTIFIC MANAGEMENT PTY LTD; MITCHELL, Jeffrey Peter; PITT, Gary; DRAFFAN, Alistair George; MAYES, Penelope Anne; ANDRAU, Laura; ANDERSON, Kelly; WO2011/94823; (2011); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem