Category: 3209-70-9

Chemistry is traditionally divided into organic and inorganic chemistry. COA of Formula: C6H7NO3, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 3209-70-9

Efficient and regioselective one-pot synthesis of 3-substituted and 3,5-disubstituted isoxazoles

(Figure Presented) A series of 3-substituted and 3,5-disubstituted isoxazoles have been efficiently synthesized in moderate to excellent yields by the reaction of N-hydroxyl-4-toluenesulfonamide with alpha,beta-unsaturated aldehydes/ketones. This novel strategy is associated with readily available starting materials, mild conditions, high regioselectivity, and wide scope.

If you are interested in 3209-70-9, you can contact me at any time and look forward to more communication. COA of Formula: C6H7NO3

Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

3209-70-9, Ethyl isoxazole-3-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3209-70-9, (a) 3-Hydroxymethyl isoxazole A solution of ethyl isoxazole-3-carboxylate (9.92 g, 70 mmol) in anhydrous ether (10 ml) was added dropwise to a stirred suspension of lithium aluminium hydride (2.67 g, 70 mmol) in ether (100 ml). The mixture was then refluxed until tlc indicated the reaction was complete (ca. 30 min) then the reaction was cautiously quenched with 2% sulphuric acid. The ether layer was separated, dried (MgSO4) and the solvent removed under reduced pressure to yield the 3-hydroxymethylisoxazole (4.23 g, 42.7 mmol, 61%); deltaH (CDCl3) 4.00 (1H, bs, OH), 4.70 (2H, s, CH2 –OH), 6.40 (1H, d, J 2 Hz, CH-4), 8.30 (1H, d, J 2 Hz, CH-5).

3209-70-9 Ethyl isoxazole-3-carboxylate 10034712, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Beecham Group p.l.c.; US4812470; (1989); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3209-70-9,Ethyl isoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.

A solution of ethyl nitroacetate (133 g, 1.0 mol) in dry dioxane (3 L) was treated with phenylisocyanate (130 g, 1.1 mol). Acetylene was bubbled through a solution, and triethylamine (111 g, 1.1 mol) was added dropwise for 5 h. The mixture was filtered, and the precipitate was washed with dioxane. The filtrate was evaporated, and the residue was distilled, providing the fraction with a boiling point of 110-112 C at 12 mmHg as the product isoxazole ester (89 g, 63%). This material was diluted into toluene (1 L), and this solution then added dropwise to a solution of diisobutyl aluminum hydride (630 mL, 0.63 mol, 1M toluene) at-75 C with stirring. The reaction mixture was stirred for 30 min, and 10% aqueous ammonium chloride (excess) was added. The organic partition was separated, washed with water (100 mL) and evaporated. The residue was distilled to provide the fraction with a boiling point of 85-90 C at 12 MMHG as the title compound (42 g, 43%).

3209-70-9, As the paragraph descriping shows that 3209-70-9 is playing an increasingly important role.

Reference£º
Patent; MERCK & CO., INC.; WO2004/58702; (2004); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

3209-70-9, Ethyl isoxazole-3-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(a) 3-Hydroxymethyl isoxazole A solution of ethyl isoxazole-3-carboxylate (9.92 g, 70 mmol) in anhydrous ether (10 ml) was added dropwise to a stirred suspension of lithium aluminium hydride (2.67 g, 70 mmol) in ether (100 ml). The mixture was then refluxed until tlc indicated the reaction was complete (ca. 30 min) then the reaction was cautiously quenched with 2% sulphuric acid. The ether layer was separated, dried (MgSO4) and the solvent removed under reduced pressure to yield the 3-hydroxymethylisoxazole (4.23 g, 42.7 mmol, 61%); deltaH (CDCl3) 4.00 (1H, bs, OH), 4.70 (2H, s, CH2 –OH), 6.40 (1H, d, J 2 Hz, CH-4), 8.30 (1H, d, J 2 Hz, CH-5)., 3209-70-9

As the paragraph descriping shows that 3209-70-9 is playing an increasingly important role.

Reference£º
Patent; Beecham Group p.l.c.; US4812470; (1989); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem