Category: 14248-66-9

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Andoh, Toshiwo; Ide, Toshinori; Saito, Morihiko; Kawazoe, Yutaka researched the compound: 3,5-Dimethyl-4-nitropyridine 1-oxide( cas:14248-66-9 ).Product Details of 14248-66-9.They published the article 《Breakage of a DNA-protein complex inducd by 4-nitroquinoline 1-oxide, 4-nitropyridine 1-oxide, and their derivatives in cultured mouse fibroblasts》 about this compound( cas:14248-66-9 ) in Cancer Research. Keywords: carcinogen protein DNA complex; nitroquinoline oxide DNA protein complex; nitropyridine oxide DNA protein complex. We’ll tell you more about this compound (cas:14248-66-9).

The effects of a number of 4-nitroquinoline 1-oxide and 4-nitropyridine 1-oxide derivatives, with varying carcinogenic potencies, on the scission of proteins-DNA complexes were studied in cultured mouse fibroblasts, strain L·P3. With 22 4-nitroquinoline 1-oxide derivatives and 12 4-nitropyridine 1-oxide derivatives tested, an excellent correlation was found between the scission effect of each compound and its carcinogenicity. All carcinogens, whether strong or weak, showed pos. results in the scission test. Strong carcinogens such as 4-nitroquinoline 1-oxide (I) [56-57-5], 2-methyl-4-nitroquinoline 1-oxide [4831-62-3], 6-methyl-4-nitroquinoline 1-oxide [715-48-0], 6-chloro-4-nitroquinoline 1-oxide [3741-12-6], and 4-hydroxyaminoquinoline 1-oxide [4637-56-3] induced the scission at a low concentration of 1 × 10-5M., while weak carcinogens such as 3-methyl-4-nitroquinoline 1-oxide [14073-00-8], 6-n-butyl-4-nitroquinoline 1-oxide [21070-32-6], 6-tert-butyl-4-nitroquinoline 1-oxide [23484-01-7], 6-n-hexyl-4-nitroquinoline 1-oxide [23484-03-9], and 6-carboxy-4-nitroquinoline 1-oxide [1425-67-8] only produced the same effect at dose levels higher than 5 × 10-5M. On the other hand, some noncarcinogenic derivatives such as 8-nitroquinoline 1-oxide [14753-18-5], 4-hydroxy-quinoline 1-oxide [3039-74-5], 4-aminoquinoline 1-oxide [2508-86-3], and 6-nitroquinoline [613-50-3] could not induce the scission, while other noncarcinogens such as 3-nitroquinoline 1-oxide [7433-86-5], 5-nitroquinoline 1-oxide [7613-19-6], and 5-nitroquinoline [607-34-1] did induce scission at concentrations >1 × 10-4M. Throughout these tests the effective concentrations of active compounds were generally much lower than the concentration at which the compounds were cytotoxic; the implication of the results and the feasibility of the present method of anal. as a screening procedure for potential carcinogens and mutagens are discussed.

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Cox, Robin A.; Yates, Keith published the article 《Thermodynamics of protonation of weak bases in sulfuric acid-water media, determined using the excess acidity method》. Keywords: thermodn protonation weak base; heat protonation base; entropy protonation base; nitroaniline protonation thermodn; phenylmethanol protonation thermodn; cyano compound protonation thermodn; ketone protonation thermodn; pyridine protonation thermodn; azine oxide protonation thermodn.They researched the compound: 3,5-Dimethyl-4-nitropyridine 1-oxide( cas:14248-66-9 ).Synthetic Route of C7H8N2O3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:14248-66-9) here.

The excess acidity method was used to investigate the thermodn. of the protonation process for those weak bases for which the ionization ratios (or optical densities) at several temperatures were measured in aqueous H2SO4. Standard enthalpies and entropies, at 25° in the aqueous reference state, are given for 13 primary, 1 secondary, and 2 tertiary nitroanilines, 3 cyclocompds., 13 triphenylmethanols, 3 other carbocation precursors, 2 ketones, 9 pyridines, and 9 azine N-oxides. Guidelines for estimating pKBH+ at any temperature for other weak bases are discussed.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Titanium(0) reagents. III. A convenient preparation of 4-pyridinamine derivatives, published in 1988, which mentions a compound: 14248-66-9, mainly applied to nitropyridine oxide reduction titanium; pyridinamine, Application of 14248-66-9.

Ti(0) slurry, easily accessible by the reduction of TiCl4 with LiAlH4 or Mg in THF, is an excellent reagent for the reduction of N-nitropyridine N-oxides, e.g., I (R = H, Me, F, Cl) to 4-aminopyridines, e.g., II. The reaction proceeds smoothly and fast at room temperature giving the amines in >90% yields.

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Liu, Xiulan published an article about the compound: 3,5-Dimethyl-4-nitropyridine 1-oxide( cas:14248-66-9,SMILESS:O=[N+](C1=C(C)C=[N+]([O-])C=C1C)[O-] ).Application In Synthesis of 3,5-Dimethyl-4-nitropyridine 1-oxide. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:14248-66-9) through the article.

The title compound was prepared from 5-methoxy-1H-benzimidazole-2-thiol by condensation with 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine followed by oxidation with m-chloroperoxybenzoic acid. The yield was 84.6%.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 14248-66-9, is researched, SMILESS is O=[N+](C1=C(C)C=[N+]([O-])C=C1C)[O-], Molecular C7H8N2O3Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Inorganic Biochemistry called Systematic coordination chemistry and cytotoxicity of copper(II) complexes with methyl substituted 4-nitropyridine N-oxides, Author is Puszko, Aniela; Brzuszkiewicz, Anna; Jezierska, Julia; Adach, Anna; Wietrzyk, Joanna; Filip, Beata; Pelczynska, Marzena; Cieslak-Golonka, Maria, the main research direction is preparation copper methylnitropyridine oxide; crystal structure copper methylnitropyridine oxide; antitumor activity copper methylnitropyridine oxide.Reference of 3,5-Dimethyl-4-nitropyridine 1-oxide.

Three new nitrato Cu(II) complexes of di-Me substituted 4-nitropyridine N-oxide were synthesized and characterized by elemental anal., magnetic, spectroscopic, thermal and x-ray methods, resp. They were isolated as trans isomers, mononuclear (μ = 1.70-1.88 μB), five-(1-2) and four-(3) coordinate species [Cu(NO3)2(H2O)L2] where L = 2,3-dimethyl- or 2,5-dimethyl-4-nitropyridine N-oxide and [Cu(NO3)2L2], L = 3,5-dimethyl-4-nitropyridine N-oxide, resp. The x-ray crystal structure of (1) (L = 2,3-dimethyl-4-nitropyridine N-oxide) was determined The organic ligands, the complexes and copper hexaqua ion as a reference were tested in vitro on the cytotoxic activity against human cancer cell lines: MCF-7 (breast), SW-707 (colon) and P-388 (murine leukemia). The complexes are relatively strong cytotoxic agents towards P-388 cell line. Comparative anal. was performed for all known Cu(II) complexes containing Me derivatives of the 4-nitropyridine N-oxide from their composition, structure and cytotoxic activities. To obtain the typical structure for these species (i.e., 4-coordinate mononuclear trans-[Cu(inorganic anion)2L2]), two Me groups must be situated on both sides of N atom(s) (i.e., NO and NO2) in the ligand. The biol. activity is strongly dependent upon the number of the Me groups and the type of cell line. The best cytotoxic results were found for the complexes without substituents or with one Me group. Generally, for all cell lines, the complexation increased cytotoxicity when compared with the free ligands.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 14248-66-9, is researched, Molecular C7H8N2O3, about Electronic spectra and structure of methyl derivatives of 4-nitropyridine N-oxide, the main research direction is methylnitropyridine oxide dipole moment intramol charge transfer.Name: 3,5-Dimethyl-4-nitropyridine 1-oxide.

The UV spectra of seven Me derivatives of 4-nitropyridine N-oxide in ethanol have been examined The electronic spectra were calculated by a modified INDO method. Transition energies, intensities and assignments were compared with UV spectra. Spectroscopic manifestations of intramol. interaction indicate that Me groups modify the electronic interaction between the N-oxide and NO2 groups mainly through a steric strain.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3,5-Dimethyl-4-nitropyridine 1-oxide, is researched, Molecular C7H8N2O3, CAS is 14248-66-9, about Electronic spectra and structure of methyl derivatives of 4-nitropyridine N-oxide.COA of Formula: C7H8N2O3.

The UV spectra of seven Me derivatives of 4-nitropyridine N-oxide in ethanol have been examined The electronic spectra were calculated by a modified INDO method. Transition energies, intensities and assignments were compared with UV spectra. Spectroscopic manifestations of intramol. interaction indicate that Me groups modify the electronic interaction between the N-oxide and NO2 groups mainly through a steric strain.

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Recommanded Product: 3,5-Dimethyl-4-nitropyridine 1-oxide. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3,5-Dimethyl-4-nitropyridine 1-oxide, is researched, Molecular C7H8N2O3, CAS is 14248-66-9, about Breakage of a DNA-protein complex inducd by 4-nitroquinoline 1-oxide, 4-nitropyridine 1-oxide, and their derivatives in cultured mouse fibroblasts. Author is Andoh, Toshiwo; Ide, Toshinori; Saito, Morihiko; Kawazoe, Yutaka.

The effects of a number of 4-nitroquinoline 1-oxide and 4-nitropyridine 1-oxide derivatives, with varying carcinogenic potencies, on the scission of proteins-DNA complexes were studied in cultured mouse fibroblasts, strain L·P3. With 22 4-nitroquinoline 1-oxide derivatives and 12 4-nitropyridine 1-oxide derivatives tested, an excellent correlation was found between the scission effect of each compound and its carcinogenicity. All carcinogens, whether strong or weak, showed pos. results in the scission test. Strong carcinogens such as 4-nitroquinoline 1-oxide (I) [56-57-5], 2-methyl-4-nitroquinoline 1-oxide [4831-62-3], 6-methyl-4-nitroquinoline 1-oxide [715-48-0], 6-chloro-4-nitroquinoline 1-oxide [3741-12-6], and 4-hydroxyaminoquinoline 1-oxide [4637-56-3] induced the scission at a low concentration of 1 × 10-5M., while weak carcinogens such as 3-methyl-4-nitroquinoline 1-oxide [14073-00-8], 6-n-butyl-4-nitroquinoline 1-oxide [21070-32-6], 6-tert-butyl-4-nitroquinoline 1-oxide [23484-01-7], 6-n-hexyl-4-nitroquinoline 1-oxide [23484-03-9], and 6-carboxy-4-nitroquinoline 1-oxide [1425-67-8] only produced the same effect at dose levels higher than 5 × 10-5M. On the other hand, some noncarcinogenic derivatives such as 8-nitroquinoline 1-oxide [14753-18-5], 4-hydroxy-quinoline 1-oxide [3039-74-5], 4-aminoquinoline 1-oxide [2508-86-3], and 6-nitroquinoline [613-50-3] could not induce the scission, while other noncarcinogens such as 3-nitroquinoline 1-oxide [7433-86-5], 5-nitroquinoline 1-oxide [7613-19-6], and 5-nitroquinoline [607-34-1] did induce scission at concentrations >1 × 10-4M. Throughout these tests the effective concentrations of active compounds were generally much lower than the concentration at which the compounds were cytotoxic; the implication of the results and the feasibility of the present method of anal. as a screening procedure for potential carcinogens and mutagens are discussed.

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Application In Synthesis of 3,5-Dimethyl-4-nitropyridine 1-oxide. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 3,5-Dimethyl-4-nitropyridine 1-oxide, is researched, Molecular C7H8N2O3, CAS is 14248-66-9, about A potentiometric study of (acid + base) equilibria in substituted 4-nitropyridine N-oxide systems in methanol and dimethyl sulfoxide. Author is Gurzynski, Lukasz; Puszko, Aniela; Makowski, Mariusz; Chmurzynski, Lech.

The acid dissociation constants for cationic acids conjugated with 4-nitropyridine N-oxides have been determined using potentiometric titration method. The measurements in the systems of thirteen 4-nitropyridine N-oxide derivatives were carried out in the polar amphiprotic methanol (MeOH) and in the aprotic protophilic DMSO (DMSO). Likewise as in the polar aprotic protophobic solvents (acetonitrile, acetone, the literature data) it was found that in MeOH for all N-oxides studied the pKa values were readily determinable, whereas in DMSO the pKa values were hardly determinable or indeterminable by using the potentiometric method. In addition, just like in our previous investigations it was revealed that the sequence of the pKa values of the cationic acids in methanol is the same as in the water and the values are lower than those determined in acetonitrile and acetone. Also, it was found that the phenomenon of cationic homoconjugation equilibrium was not present in the systems involving 4-nitropyridine N-oxide derivatives in both solvents used. Furthermore, protonation energies, ΔEprot, and Gibbs free energies, ΔGprot, in vacuo have been compared with acid dissociation constants (expressed as pKMeOHa values) of the protonated N-oxides determined by potentiometric titration in methanol to establish a correlation between these magnitudes.

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Isoxazole – Wikipedia,
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Quality Control of 3,5-Dimethyl-4-nitropyridine 1-oxide. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3,5-Dimethyl-4-nitropyridine 1-oxide, is researched, Molecular C7H8N2O3, CAS is 14248-66-9, about N-Oxides of 11-deficient N-heteroaromatics. VIII. Photochemical rearrangement of pyridine and quinoline 1-oxides having sterically hindered 4-nitro group. Author is Kaneko, Chikara; Yokoe, Ichiro; Yamada, Sachiko.

EtOH (550 ml.) containing 1 g. 3,5,4-Me2(O2N)C5H2NO irradiated (N atm.) 1.5 hrs. by a Hanovia 450 w. high-pressure Hg-arc lamp placed inside a watercooled pyrex immersion well, the solvent evaporated, and the residue recrystallized from 1:10 MeOH-Me2CO yielded 30% 3,5,4-Me2(HO)C5H2NO, m. 184°, (Hertog and Combe, CA 47, 5938c). A mechanistic pathway involving nitro-nitrite rearrangement as a key step was tentatively suggested. Steric hindrance by the 2 ortho Me groups may prevent abstraction of H from the solvents by the excited species and thus inhibit formation of the 4-hydroxyamino compound Under the above conditions photolysis of 4-nitroquinoline 1-oxide gave only 7% 2,4-dihydroxyquinoline, m. 300°, whereas 3-methyl-4-nitroquinoline 1-oxide gave 30% 3-methyl-2,4-dihydroxyquinoline, m. 264-5°; monoacetate, m. 241-3°. Contrary to the photolysis of 4-nitro derivatives of pyridine, 2-picoline, 3-picoline, and 2,6-lutidine 1-oxides, the presence of O did not affect the formative of these products but the yields of the corresponding 4-hydroxy derivatives were somewhat lower.

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Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem