Category: 108511-97-3

108511-97-3, Isoxazol-4-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 4 (11.51 g, 0.022 mol),Isoxazol-4-ylamine (11.85g, 0.022mol) and p-toluenesulfonic acid(~0.40g) of the suspension was placed in a mechanical stirrer,In a round bottom flask with an oil bath and a Dean-Stark condenser,The reaction mixture is heated to reflux (internal temperature 150-155 C,Oil bath temperature 170-180 C) 15-18 hours,The reaction was monitored by TLC at the same time. After completion of the reaction, the reaction mixture was cooled to 80 C, and methanol (27 mL) was slowly added through a dropping funnel.The reaction mixture was slowly cooled to room temperature with stirring.The resulting solid was filtered and washed with methanol (45 mL).And dried at 100-120 C for 2 hours.Obtained as a white solid ((3-((4,6-difluorobenzo[d]thiazol-2-yl)methyl)thio)-1-(isoxazol-4-ylamino)-1-oxyl Propane-2-carboxylic acid (9H-fluoren-9-yl)yl carbamate (Compound 5), 9.26 g,The yield was 71%.

The synthetic route of 108511-97-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Qin Jiwei; (13 pag.)CN108892664; (2018); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

108511-97-3, Isoxazol-4-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2-[(phenylmethyl)oxy]-5-(4-pyridinyl)benzoic acid (may be prepared as described in Description 79; 100 mg, 0.30 mmol), EDC (172 mg, 0.90 mmol) and HOBT (137 mg, 0.90 mmol) in dimethylformamide (3 ml) was stirred in air at room temperature for 1 h, then 4-isoxazolamine (may be prepared as described in Description 95; 100 mg, 1.189 mmol) was added in one charge. The reaction mixture was stirred at room temperature overnight. The reaction mixture was diluted with water (30 mi). The solid was filtered and dried in vacuo to obtain crude product, which was purified with Prep- HPLC (Waters, X-Bridge, 5Mm;30x100mm; A=0.05%NH3.H2O/water, B:MeCN;v=30ml/min;0-7min, 42%-54%; 7-12min, 95%; t=8.0min.) to yield the title compound as a white solid. 34 mg.’HNMR (400 MHz, DMSO-d6): 10.60 (s, 1 H), 9.27 (s, 1 H), 8.65 (s, 1 H), 8.62 (d, 2H, J=5.6), 8.08 {d, 1 H, J=2.0), 7.98 (dd, 1 H, J=2.0, 8.4), 7.74 (d, 2H, J=5.6), 7.52 (d, 2H, J=7.6), 7.42-7.33 (m, 4H), 5.36 (s, 2H).MS (electrospray); m/z [M+H]+ = 372.1

108511-97-3 Isoxazol-4-amine 13804278, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Patent; GLAXO GROUP LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; NICHOLS, Paula Louise; EATHERTON, Andrew John; BAMBOROUGH, Paul; JANDU, Karamjit Singh; PHILPS, Oliver James; ANDREOTTI, Daniele; WO2011/38572; (2011); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem