Tag: M.W:400-500

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228690-37-6,(R)-1-Phenylethyl (5-(4-bromophenyl)-3-methylisoxazol-4-yl)carbamate,as a common compound, the synthetic route is as follows.

Step 6: l-{4′-[3-Methyl-4-((R)-l-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4- yl}-cyclopropanecarboxylic acid: [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-carbamic acid (R)- l- phenyl-ethyl ester (0.248g, 0.62mmol), 4-(l’-carboxyl-cyclopropyl)phenylboronic acid (0.160g, 0.62mmol), and sodium carbonate (0.155g, 1.85mmol) were combined in 2: 1 DME:H20. The solution was purged with N2 for 10 minutes, and then bis(triphenylphosphine)palladium(II) dichloride (0.047g, 0.06mmol) was added. The reaction was purged with N2 for an additional 10 minutes, and then stirred in a sealed tube at 80C for 2 hours. The mixture was partitioned between EtOAc and H20, and the aqueous layer was extracted with EtOAc. The combined organic layers were dried over MgSO/t, filtered, and concentrated, and the residue was purified by silica gel chromatography to give the title compound. Mass spec, data (M+H) = 483.

1228690-37-6, The synthetic route of 1228690-37-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMIRA PHARMACEUTICALS, INC.; BRISTOL-MYERS SQUIBB COMPANY; BRITTAIN, Jason, Edward; SEIDERS, Thomas, Jon; HUTCHINSON, John, Howard; KING, Christopher, David; ROSSO, Victor, W.; WO2012/78805; (2012); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

1228690-37-6, (R)-1-Phenylethyl (5-(4-bromophenyl)-3-methylisoxazol-4-yl)carbamate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Argon was bubbled through the mixture of compound CIII-7 (200 mg, 0.6 mmol), compound CIII-8 (242 mg, 0.6 mmol) and Na2C03 (127 mg, 1.20 mmol) in a mixed solvent of DME/H20 (6 mL, v/v = 3/1). Then the catalyst Pd(dppf)Cl2 (22 mg, 0.03 mmol) was added. The mixture was heated to 80 C and stirred for 2 hours. The mixture was filtered through Celite and the filtrate was concentrated. The residue was purified by column chromatography over silica gel (PE/EA = 5/1) to yield compound CIII-9 (290 mg, yield 91 >). MS (ESI) m/z (M+H)+ 526.3., 1228690-37-6

The synthetic route of 1228690-37-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.; WO2013/25733; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem