Tag: M.W=250-300

Zhu, Daqian published the artcileDiscovery of novel N-substituted carbazoles as neuroprotective agents with potent anti-oxidative activity, Related Products of isoxazole, the publication is European Journal of Medicinal Chemistry (2013), 81-88, database is CAplus and MEDLINE.

Carbazole moiety is an important scaffold with a variety of biol. applications, for example, anti-oxidative stress. Our previous synthesized carbazoles were screened for their neuroprotective properties against two individual oxidative stresses. Some of the new carbazole derivatives were observed with modest to good neuroprotective effects on neuronal cells HT22 against cell injury induced by glutamate or homocysteic acid (HCA). Substituents introduced to the carbazole ring system play crucial roles in their biol. activities. In particular, a bulky group favors the neuroprotective activity of the compounds One of the new compounds, I, showed the best neuroprotective effects, which might result from its anti-oxidative activity with a GSH-independent mechanism. These findings might provide an alternative strategy for the development of novel carbazole derivatives for the treatment of CNS diseases such as Alzheimer’s disease.

European Journal of Medicinal Chemistry published new progress about 57103-14-7. 57103-14-7 belongs to isoxazole, auxiliary class Fused Tricycles,Carbazoles, name is 9-(4-Fluorophenyl)-9H-carbazole, and the molecular formula is C26H25N5O3, Related Products of isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Ambrose, James F. published the artcileElectrochemical and spectroscopic properties of cation radicals. III. Reaction pathways of carbazolium radical ions, COA of Formula: C18H12FN, the publication is Journal of the Electrochemical Society (1975), 122(7), 876-94, database is CAplus.

The anodic oxidation pathways of seventy-six ring-substituted carbazoles are examined using electrochem. and spectral techniques. The reactivity of the substituted carbazole cation radicals is also determined The C-3, C-6, and N-9 positions are extremely reactive; if these sites are not blocked by inert substituents the cation radicals generated by electrolytic oxidation react rapidly via coupling-deprotonation. In some cases, substituents are eliminated from the C-3 and C-6 positions in the cation radicals followed by coupling to form substituted bicarbazyls. In other cases, relatively stable cation radicals are obtained and their EPR and visible absorption spectra are observed The reactivities of substituted carbazole cation radicals are greater than those of analogous di- and triphenylaminium ions due to the planarity of the carbazole aromatic rings.

Journal of the Electrochemical Society published new progress about 57103-14-7. 57103-14-7 belongs to isoxazole, auxiliary class Fused Tricycles,Carbazoles, name is 9-(4-Fluorophenyl)-9H-carbazole, and the molecular formula is C18H12FN, COA of Formula: C18H12FN.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem