Tag: M.W=100-150

Domagalina, E.; Slawik, T. published the artcile< Thermoanalytical studies of organic compounds. Part V. Rearrangement of acylated 3-hydroxy-1,2-benzisoxazoles>, Product Details of C7H5NO2, the main research area is benzisoxazole acyl thermal decomposition; benzoxazolinone acyl.

Thermal anal. of new benzoyl- and methoxy- and ethoxycarbonyl-3-hydroxybenzisoxazole (e.g., I) was carried out derivatog. In the serial stages of tautomeric, isomeric and decarboxylic transformation, new N-acylated benzisoxazolin-3-ones and -2-ones and 3-alkylbenzoxazolin-2-ones were obtained.

Journal of Thermal Analysis published new progress about Thermal decomposition. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Product Details of C7H5NO2.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Yoshji, Kiyotaka; Ohba, Yoshihiro; Nishiwaki, Tarozaemon published the artcile< β-Ribo- and α-arabinonucleosides containing the 1,2-benzisoxazole and 1,2-benzisothiazole rings>, Quality Control of 21725-69-9, the main research area is benzisoxazole containing ribonucleoside arabinonucleoside; benzisothiazole containing ribonucleoside; ribofuranose condensation benzisoxazole benzisothiazole; arabinofuranose condensation benzisoxazole.

The reaction of the silylated base of 1,2-benzisoxazol-3(2H)-one (I, R = R1 = H, X = O), its 7-Me derivative I (R = Me, R1 = H, X = O), and the 5-methylbenzisothiazolone I (R = H, R1 = Me, X = S), resp., with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose followed by basic deprotection gave the corresponding β-D-ribonucleosides II. Similarly, 1-O-acetyl-2,3,5-tri-O-benzoyl-α-D-arabinofuranose reacted with I (R = R1 = H, X = O) in the presence of stannic chloride, to afford the corresponding α-arabinonucleoside III. Structural proofs for these nucleosides are provided from elemental analyses and 1H and 13C NMR spectra.

Journal of Heterocyclic Chemistry published new progress about Glycosylation. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Quality Control of 21725-69-9.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Szilagyi, Bence; Kovacs, Peter; Ferenczy, Gyorgy G.; Racz, Anita; Nemeth, Krisztina; Visy, Julia; Szabo, Pal; Ilas, Janez; Balogh, Gyorgy T.; Monostory, Katalin; Vincze, Istvan; Tabi, Tamas; Szoko, Eva; Keseru, Gyorgy M. published the artcile< Discovery of isatin and 1H-indazol-3-ol derivatives as D-amino acid oxidase (DAAO) inhibitors>, Category: isoxazole, the main research area is isatin indazolol derivative preparation amino acid oxidase inhibitor schizophrenia; Binding thermodynamics; Optimization; Protonation state; d-Amino acid oxidase.

D-Amino acid oxidase (DAAO) is a potential target in the treatment of schizophrenia as its inhibition increases brain D-serine level and thus contributes to NMDA receptor activation. Inhibitors of DAAO were sought testing [6+5] type heterocycles and identified isatin derivatives as micromolar DAAO inhibitors. A pharmacophore and structure-activity relationship anal. of isatins and reported DAAO inhibitors led the authors to investigate 1H-indazol-3-ol derivatives and nanomolar inhibitors were identified. The series was further characterized by pKa and isothermal titration calorimetry measurements. Representative compounds exhibited beneficial properties in in vitro metabolic stability and PAMPA assays. 6-Fluoro-1H-indazol-3-ol (37) significantly increased plasma D-serine level in an in vivo study on mice. These results show that the 1H-indazol-3-ol series represents a novel class of DAAO inhibitors with the potential to develop drug candidates.

Bioorganic & Medicinal Chemistry published new progress about Antipsychotics. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Category: isoxazole.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Uno, Hitoshi; Kurokawa, Mikio published the artcile< Studies on 3-substituted 1,2-benzisoxazole derivatives. IV. Rearrangement of N-substituted 2H-1,2-benzisoxazolin-3-one to 2-substituted 2H-1,3-benzoxazin-4-one>, Category: isoxazole, the main research area is benzoxazinone; benzisoxazolinone ring expansion rearrangement; alkylation hydroxybenzisoxazole.

The base catalyzed ring expansion of 2-substituted 2H-1,2-benzisoxazolin-3-ones I (R = Ph, CO2Me, COPh, COMe, CCH, R1 = H; R = R1 = Ph; R = CO2Et, R1 = Me) to 2-substituted 2H-1,3-benzoxazin-4-ones II occurred during the alkylation of hydroxy-1,2-benzisoxazole.

Chemical & Pharmaceutical Bulletin published new progress about Rearrangement. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Category: isoxazole.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Kinstle, Thomas H.; Darlage, Larry J. published the artcile< Thermal conversion of 3-hydroxy-1,2-benzisoxazole to benzoxazolinone>, HPLC of Formula: 21725-69-9, the main research area is benzisoxazoles pyrolysis; pyrolysis benzisoxazoles; oxazolinones benz; benzoxazolinones; isoxazoles benz pyrolysis.

3-Hydroxy-1,2-benzisoxazole (I), prepared according to known methods, is pyrolyzed at 0.10 mm. at 340-450° to give benzoxazolinone (II); N.M.R. data for II are given; ir data are given for I and II. Mechanisms in which the nitrene, o-HOC6H4CON, and 3,5-cyclohexadien-1-one-2-spiro-3′-aziridin-2′-one are intermediates are discussed.

Journal of Heterocyclic Chemistry published new progress about 21725-69-9. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, HPLC of Formula: 21725-69-9.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Kalkote, Uttam R.; Goswami, Das D. published the artcile< New synthesis of 1,2-benzisoxazole derivatives>, Related Products of 21725-69-9, the main research area is benzisoxazole; salicylohydroxamic acid thionyl chloride cyclization; acetophenone oxime hydroxy cyclization; salicylaldoxime cyclization thionyl chloride.

N-Phenylsalicylohydroxamic acids (I, R = H, Cl, Br, I) were treated with SOCl2 in the presence of pyridine in anhydrous ether at 0° to give II (via III). IV (R3 = H, OH, Me; R2 = H, Me, Cl, Br, etc.) were similarly treated to give V.

Australian Journal of Chemistry published new progress about 21725-69-9. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Related Products of 21725-69-9.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Jin, Wen Bin; Xu, Chen; Cheung, Qipeng; Gao, Wei; Zeng, Ping; Liu, Jun; Chan, Edward W. C.; Leung, Yun-Chung; Chan, Tak Hang; Wong, Kwok-Yin; Chen, Sheng; Chan, Kin-Fai published the artcile< Bioisosteric investigation of ebselen: Synthesis and in vitro characterization of 1,2-benzisothiazol-3(2H)-one derivatives as potent New Delhi metallo-β-lactamase inhibitors>, HPLC of Formula: 21725-69-9, the main research area is benzoisothiazolone preparation metallo beta lactamase inhibitor SAR; 1,2-benzisothiazol-3(2H)-one; Bioisosteric replacement; Carbapenem-resistant Enterobacteriaceae; Ebselen; New Delhi metallo-β-lactamase inhibitors.

In the present study, by employing the concept of bioisosteric replacement of the selenium moiety of ebselen, a small compound library of 2-substituted 1,2-benzisothiazol-3(2H)-ones, compounds I [R = 4-lCC6H4, 4-HOCH2C6H4, cyclohexyl, etc.] were designed, synthesized and evaluated their cytotoxicity and synergistic activity in combination with meropenem against the E. coli Tg1 (NDM-1) strain. The most promising compound I [R = 4-lCC6H4] demonstrated potent synergistic activity against a panel of clin. isolated NDM-1 pos. CRE strains with FICI as low as 0.09. Moreover, its IC50 value and inhibition mechanism were also confirmed by using the enzyme inhibition assay and the ESI-MS anal. resp. Importantly, compound I [R = 4-lCC6H4] has acceptable toxicity and is not a PAINS. Because of its structural simplicity and potent synergistic activity in combination with meropenem, we propose that compound 3a may be a promising meropenem adjuvant and a new series of such compounds may worth further investigations.

Bioorganic Chemistrypublished new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, HPLC of Formula: 21725-69-9.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Ueda, Mitsuru; Harada, Toshiaki; Aoyama, Shigeto; Imai, Yoshio published the artcile< Synthesis of polyamides from active diacyl derivatives of 3-hydroxy-1,2-benzisoxazole and diamines under mild conditions>, Application In Synthesis of 21725-69-9, the main research area is benzisoxazole ester amide polymer; polyamide benzisoxazole; aminolysis benzoisoxazole ester amide.

New active diesters and diamides derived by O- or N-acylation of 3-hydroxy-1,2-benzisoxazole [21725-69-9] were prepared for use in polyamide synthesis. The active esters and amides reacted readily with amines to give quant. yields of amides. The high reactivity of these active esters and amides was discussed in relation to the electron-withdrawing effect of the leaving group and intramol. general-base catalysis. Solution polycondensation of the new diesters and diamides with aliphatic and aromatic diamines proceeded slowly under mild conditions to produce polyamides with inherent viscosities up to 1.5.

Journal of Polymer Science, Polymer Chemistry Editionpublished new progress about Aminolysis. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Application In Synthesis of 21725-69-9.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Van Eker, Daniel; Chauhan, Jay; Murphy, William A.; Conlon, Ivie L.; Fletcher, Steven published the artcile< Chromatography-free, Mitsunobu-triggered heterocyclizations of salicylhydroxamic acids to 3-hydroxybenzisoxazoles>, Quality Control of 21725-69-9, the main research area is hydroxybenzisoxazole preparation; salicylhydroxamic acid heterocyclization Mitsunobu.

A swift and efficient preparation of 3-hydroxybenzisoxazoles I (R = H, 6-F, 6-Cl, 7-OCH3, 5-NO2, etc.) by the Mitsunobu-triggered heterocyclizations of salicylhydroxamic acids, which can be isolated by an acid-base work-up was reported. As expected, a range of functional groups was compatible with the chem.

Tetrahedron Letterspublished new progress about Heterocyclization. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Quality Control of 21725-69-9.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Raw, Steven A.; O’Kearney-McMullan, Anne M.; Graham, Mark A. published the artcile< Unexpected ring-expansion of 1,2-benzisoxazol-3-ones>, Related Products of 21725-69-9, the main research area is benzisoxazolone ring expansion reaction mechanism; benzoxazinone preparation.

A novel and unexpected ring-expansion reaction of 1,2-benzisoxazol-3-ones is identified. The scope of this reaction is exemplified and the proposed mechanism is also implicated in another degradation process. This reaction also represents a new method for accessing the 4H-1,3-benzoxazin-4-one, e.g., I, skeleton.

Tetrahedron Letterspublished new progress about Azoles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Related Products of 21725-69-9.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem