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In this study, nitrogen, sulfur and oxygen co-doped carbon armored cobalt sulfide (Co/Co9S8@N-S-O-C) composite was synthesized, characterized and used to activate peroxymonosulfate (PMS) for the degradation of sulfamethoxazole (SMX). SMX (0.04 mM) can be completely degraded within 20 min in the presence of 0.8 mM PMS and 0.1 g/L Co/Co9S8@N-S-O-C composite. The first-order kinetics constant of SMX degradation was 0.307 min-1, and the mineralization of SMX was 30.1 %. The Quenching experiments of the free radicals and the identification of degradation products demonstrated that sulfate radicals played a dominant role in SMX degradation. The degradation rate of SMX increased with temperature, and activation energy was calculated to be 48.6 kJ/mol. The degradation rate of SMX increased firstly then decreased with increase of pH. Chloridion and humic acid decreased the degradation rate of SMX no matter what their initial concentration was. The effect of carbonate on SMX degradation depended on its initial concentration. Co/Co9S8@N-S-O-C composite showed good stability, the removal efficiency of SMX was 98.4 % in the fifth experiment. Based on the characterization results of the catalyst before and after use, it was concluded that cobalt, sulfur, pyridnic N and graphitic N were responsible for PMS activation.

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Isoxazole | C3H3NO – PubChem

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The key intermediates, 3-(5-methyl-3-isoxazolyl)-2-arylimino-1,3-thiazolan- 4-ones (3), were obtained from 3-amino-5-methylisoxazole (1) by reaction with chloroacetyl chloride followed by treatment with aryl isothiocyanates. Cyclocondensation of 3 with mercapto acetic acid furnished novel isoxazolyl 1,6-dithia-4,9-diazaspiro[4,4]nonane-3,8-diones (4). Cycloaddition of 3 with benzonitrile oxides afforded novel isoxazolyl 1-oxa-6-thia-2,4,9-triazaspiro[4, 4]non-2-ene-8-ones (5).

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Endocrine disrupting chemicals (EDCs) can be present as trace-level organic pollutants in aquatic environments and are difficult to measure and remove. In this study, a method was developed using a modified quartz crystal microbalance (QCM) to investigate the adsorption of EDCs by zeolite filter. Bisphenol A (BPA), oestrone (E1), oestradiol (E2), and sulfamethoxazole (SMZ) were selected as four representative endocrine disruptors in a water environment and their adsorption on zeolite was measured by QCM in real-time. The adsorption results were well described by a pseudo-first-order kinetic model and by a Sips isotherms model. The adsorption of the four adsorbents is related to their molecular structure, molecular polarity, and chargeability. The removal rate of EDCs by zeolite for different initial concentrations appeared to plateau, with the removal rates of the four selected EDCs all above 80% except for the maximum initial concentration. Changes of pH and ionic strength had no effect on the adsorption capacity of the four EDCs, with a removal rate of about 90%. However, the response time at pH 5.50 was about 300 s faster than that at pH 8.50 and the addition of electrolyte shortened the mass response time of several organic compounds on QCM.

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The efficient cycloaddition reactions were carried out to afford the novel 3,5-disubstituted-dihydroisoxazoles from methyl undec-10-enoate and isoxazoles, triazole and tetrazolo-triazole from methyl undec-10-ynoate. The reactions occurred under relatively mild conditions and afforded the desired products in good yields.

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A first-principle method has been successfully developed for the prediction of pKa values of aromatic heterocyclic compounds in DMSO solution with a precision of 1.1 pKa units. Comparison of theoretical results and experimental data (where available) also shows excellent consistency. Armed with this useful approach, the pKa values for a series of aromatic heterocycles were calculated in DMSO. Moreover, a discussion of the relationships between hydrogen acidities and molecular structures is conducted for the first time (determinants of C-H acidities, substituent effects, and some practical use of dehydrometalation). These statistics could be useful for synthetic chemists to design proper routes for introduction of aromatic heterocyclic moiety, especially when dehydrometalation reactions are used.

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The review presents the first analysis and systematic discussion of data published in the last 35 – 40 years on the use of molybdenum compounds and complexes in organic synthesis and catalysis of various ion coordination and radical reactions. Detailed account is given of the key trends in the use of molybdenum complexes as catalysts of alkene epoxidation and oxyketonation, oxidation of sulfur, nitrogen and phosphorus compounds, hydrosilylation of 1,3-dienes, ketones and aldehydes, hydrostannylation of acetylenes and hydrogermylation of norbornadienes. Considerable attention is paid to the description of new reactions and in situ generation of highly reactive hypohalites, ROX and HOX, induced by molybdenum complexes and the use of hypohalites in oxidative transformations. Data on the application of molybdenum complexes in well-known reactions are discussed, including Kharasch and Pauson – Khand reactions, allylic alkylation of C-nucleophiles, aminocarbonylation of halo derivatives and oligomerization of cyclic dienes, trienes, alkynes and 1,3-dienes. The last Section of the review considers ‘unusual’ organic reactions involving molybdenum compounds and complexes.

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3,5-Di hydroxy morpholine derivatives having antitumor activity and methods of preparation thereof, are disclosed.

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Factors affecting the ability of potentially chelating amine ligands to form chelated fluoroboron cations are explored by19F and 11B NMR spectroscopy and fast atom bombardment mass spectrometry (FAB-MS). Five-membered chelate rings form much more readily than six-membered. Some potentially chelating ligands give rise to additional fluoroboron species by various redistribution and decomposition reactions.

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A series of 2-phenyl-4-methyl-1,3-selenazole-5-carboxylic acid derivatives (8a-f, 9a-m) were synthesized and evaluated for inhibitory activity against xanthine oxidase in vitro. Structure-activity relationship analyses have also been presented. Most of the target compounds exhibited potency levels in the nanomolar range. Compound 9e emerged as the most potent xanthine oxidase inhibitor (IC50 Combining double low line 5.5 nM) in comparison to febuxostat (IC50 Combining double low line 18.6 nM). Steady-state kinetics measurements with the bovine milk enzyme indicated a mixed type inhibition with Ki and Ki’ values of 0.9 and 2.3 nM, respectively. A molecular modeling study on compounds 9e was performed to gain an insight into its binding mode with xanthine oxidase, and to provide the basis for further structure-guided design of new non-purine xanthine oxidase inhibitors related with 2-phenyl-4-methyl-1,3-selenazole-5-carboxylic acid scaffold.

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Isoxazole – Wikipedia,
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Cyclocondensation of methyl 2-(5-methylisoxazol-3-yl)imino-3,3,3- trifluoropropionate with 1,3-binucleophiles such as benzamidines, aminothiazoline, and 2-aminocrotonic acid nitrile results in trifluoromethyl-containing 3,5-dihydro-4-ones, 2,3-dihydro-6H-imidazo[2,1-b] thiazol-5-one, and 4,5-dihydro-1H-pyrrole-3-carbonitrile.

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Isoxazole – Wikipedia,
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