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COMPOUNDS AND METHODS FOR MODULATING FXR

Compounds of formula (I): formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and diseases related to dyslipidemia.

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Isoxazole – Wikipedia,
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COMPOUNDS AND METHODS FOR MODULATING FXR

Compounds of formula. wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.

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The present technology is directed to compounds, compositions, and methods related to modulation of FXR. In particular, the present compounds and compositions may be used to treat FXR-mediated disorders and conditions, including, e.g., liver disease, hyperlipidemia, hypercholesteremia, obesity, metabolic syndrome, cardiovascular disease, gastrointestinal disease, and atherosclerosis, and renal disease.

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NOVEL FXR (NR1H4) BINDING AND ACTIVITY MODULATING COMPOUNDS

The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

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Application of 946426-89-7, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 946426-89-7, molcular formula is C13H11Cl2NO2, introducing its new discovery.

A substituted bicyclic compound as bile acid receptors agonist and used thereof

The present invention refers to substituted bicyclic compounds, compositions including same and said substituted bicyclic compounds to bath method number about number are disclosed. In particular the present invention refers to anti-cancer agents x receptor (fxr, nr1h 4) for activating a bile acid receiving chain trans substituted bicyclic compounds therapeutic composition about number are disclosed. (by machine translation)

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Discovery of 5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazole-4-methanol

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FXR MODULATORS AND METHODS OF THEIR USE

The present disclosure is directed to modulators of farnesoid X receptor. Methods of making and using these modulators is also described.

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The important role of 5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazole-4-methanol

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AN ISOXAZOLE DERIVATIVES AS NUCLEAR RECEPTOR AGONISTS AND USED THEREOF

The present invention relates to isoxazole derivatives, including pharmaceutical compositions and for the preparation of isoxazole derivatives. And more particularly the present invention provided a pharmaceutical composition of isoxazole derivatives for activation of Farnesoid X receptor(FXR, NR1H4).

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Heterocyclic cyclopropyl-substituted FXR binding compounds

The present invention relates to compounds defined by formula (I):or an enantiomer, diastereomer, tautomer, solvate or pharmaceutically acceptable salt thereof, where in R1 and R2 are independently from each other selected from hydrogen, fluorine and C1-C3 alkyl; X is which bind to the NR1H4 receptor (FXR) and act as agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, such as the prophylaxis and/or treatment of chronic intrahepaticor some forms of extrahepatic cholestatic conditions, liver fibrosis resulting from chronic cholestatic conditions, acute intraheptic cholestatic conditions, obstructive or chronic inflammatory disorders that arise out of improper bile composition, gastrointestinal conditions with a reduced uptake of dietary fat and fat-soluble dietary vitamins, inflammatory bowel diseases, lipid and lipoprotein disorders, Type II Diabetes, clinical complications of Type I and Type II Diabetes.

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Properties and Exciting Facts About 5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazole-4-methanol

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ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF

The present invention provides compounds of Formula I, pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.

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Novel FXR (NR1H4) binding and activity modulating compounds

The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds

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Reference£º
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