Category: 89102-73-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.89102-73-8,Isoxazol-3-ylmethanol,as a common compound, the synthetic route is as follows.,89102-73-8

A mixture of 10.0 g (100.9 mmol) isoxazol-3-ylmethanol and THF is cooled to 0C and 4.0 g (100.9 mmol) 60% NaH are added in small portions. The reaction mixture is stirred for 45 min, and then 16.4 g (84.6 mmol) 2-chloro-5-bromo-pyrimidine in DMF is added. The reaction mixture is stirred for 45 min at RT, then cooled to 0C and diluted with water. The precipitate is filtered off, washed with water and dried yielding 20.1 g 3-[(5-bromopyrimidin-2-yl)oxymethyl]isoxazole .

The synthetic route of 89102-73-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BLUM, Andreas; GODBOUT, Cedrickx; HEHN, Joerg, P.; PETERS, Stefan; (74 pag.)WO2017/194453; (2017); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

89102-73-8, Isoxazol-3-ylmethanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

89102-73-8, In 55 mL of N,N-dimethylformamide a suspension of 2.12 g (53 mmol) of 60% sodium hydride in paraffin was prepared under argon atmosphere. After cooling to 0C, a solution of 4.5 g (53 mmol) of isoxazol-3-ylmethanol (Intermediate 22) in 50 mL of N,N-dimethylformamide was added dropwise. The mixture was stirred at 40C for 15 minutes, and then allowed to cool down at room temperature. A solution of 15.2 g (52.4 mmol) of 3-(3,4-difluorophenyl)isoxazol-5-methyl methylsulfonate (Intermediate 4) in 110 mL deN,N-dimethylformamide was added dropwise. The mixture was stirred at 70C for 1 h, cooled, poured over 1.7 L of a 5% sodium bicarbonate solution, and extracted three times with ethyl acetate. The combined organic extracts were washed with 1.7 L of deionized water, and with 1.7 L of a saturated solution of sodium chloride, then dried over anhydrous sodium sulfate, and filtered. The solvent was distilled off under reduced pressure. The residue was chromatographed on a silica gel column, eluting with dichloromethane. Relevant fractions were combined to give, once evaporated the solvent, 14.5 g (quantitative yield) of a white solid. Mass spectrum (m/e): 278 (M+).

As the paragraph descriping shows that 89102-73-8 is playing an increasingly important role.

Reference£º
Patent; LABORATORIOS S.A.L.V.A.T., S.A.; EP1437349; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

89102-73-8,89102-73-8, Isoxazol-3-ylmethanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4- [4-(6-Amino-4-methoxypyridin-3-yl)piperidine-l -carbonyl] -3 -fluorophenol (25.0 mg; 0.07 mmol), (l,2-oxazol-3-yl)methanol (6.8 mg; 0.17 mmol), TPP (50.0 mg; 0.19 mmol) and DTAD (40.0 mg; 0.17 mmol) in l,4-dioxane (3 mL) are stirred for 1 hour at 60C. The reaction mixture is purified by RP-HPLC (ACN/water + TFA). Yield: 20.0 mg (39%) ESI-MS: m/z = 427 [M+H]+ Rt(HPLC): 0.52 min (method 11)

89102-73-8 Isoxazol-3-ylmethanol 12905096, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BERRY, Angela Kay; BOUYSSOU, Thierry; GOTTSCHLING, Dirk; HEINE, Niklas; NETHERTON, Matthew Russell; (119 pag.)WO2019/161010; (2019); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem