Category: 80348-66-9

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Pyrrolidine compounds of Formula (I), (wherein R1, R2 , R3, R4, R5, R6a, R6b, R 7 and R8 are defined herein) are described. The compounds are modulators of CCR5 chemokine receptor activity. The compounds are useful, for example, in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Synthetic Route of 80348-66-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 80348-66-9, Name is Isoxazol-4-ol, molecular formula is C3H3NO2. In a Patent，once mentioned of 80348-66-9

The present invention is directed to pyrrolidine compounds of the formula 1: (wherein R 1, R 2, R 3, R 4, R 5, R 6 and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.

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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Reference of 80348-66-9, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 80348-66-9, Isoxazol-4-ol, introducing its new discovery.

ISOLATION, STRUCTURE AND SYNTHESIS OF 4-HYDROXYISOXAZOLE (TRIUMFEROL), A SEED GERMINATION INHIBITOR FROM AN AFRICAN PLANT

The isolation, characterization and an efficient synthesis of 4-hydroxyisoxazole 1, a plant growth regulator isolated from an African plant is reported.It is a new compound, which despite the simple structure, had eluded synthesis.

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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem