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PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF

Disclosed are compounds of Formula I effective as cytotoxic agents. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

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Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

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Direct synthesis of anilines and nitrosobenzenes from phenols

A one-pot synthesis of anilines and nitrosobenzenes from phenols has been developed using an ipso-oxidative aromatic substitution (iSOAr) process. The products are obtained in good yields under mild and metal-free conditions. The leaving group effect on reactions that proceed through mixed quionone monoketals has also been investigated and a predictive model has been established.

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Rapid Syntheses of Some Indole Alkaloids of the Calabar Bean

A rapid, efficient route to 3,3-disubstituted oxindoles from o-iodo anilines has been developed.It involves the cyclisation of the corresponding fumarate amides 4 and 15 with butyllithium at -100 deg C in the presence of an excess of trimethylchlorosilane.An X-ray crystal structure of 4 suggests that the speed and efficiency of this intramolecular Michael addition is dependent on the conformation adopted by 4 which is particularly suitable for the reaction.This method has been applied to the synthesis of the alkaloids physovenine, physostigmine and esermethole in very high overall yields.

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Methanol dehydrogenation by iridium N-heterocyclic carbene complexes

A series of homogeneous iridium bis(N-heterocyclic carbene) catalysts are active for three transformations involving dehydrogenative methanol activation: acceptorless dehydrogenation, transfer hydrogenation, and amine monoalkylation. The acceptorless dehydrogenation reaction requires base, yielding formate and carbonate, as well as 2-3 equivalents of H2. Of the few homogeneous systems known for this reaction, our catalysts tolerate air and employ simple ligands. Transfer hydrogenation of ketones and imines from methanol is also possible. Finally, N-monomethylation of anilines occurs through a borrowing hydrogen reaction. Notably, this reaction is highly selective for the monomethylated product.

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Isoxazole – Wikipedia,
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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Product Details of 33282-15-4, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 33282-15-4, name is 5-(4-Hydroxyphenyl)isoxazole-3-carboxylic acid. In an article£¬Which mentioned a new discovery about 33282-15-4

Chemoenzymatic Synthesis of Substituted Azepanes by Sequential Biocatalytic Reduction and Organolithium-Mediated Rearrangement

Enantioenriched 2-aryl azepanes and 2-arylbenzazepines were generated biocatalytically by asymmetric reductive amination using imine reductases or by deracemization using monoamine oxidases. The amines were converted to the corresponding N?-aryl ureas, which rearranged on treatment with base with stereospecific transfer of the aryl substituent to the 2-position of the heterocycle via a configurationally stable benzyllithium intermediate. The products are previously inaccessible enantioenriched 2,2-disubstituted azepanes and benzazepines.

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Isoxazole – Wikipedia,
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New explortion of 5-(4-Hydroxyphenyl)isoxazole-3-carboxylic acid

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Nickel-Catalyzed Asymmetric Propargylic Amination of Propargylic Carbonates Bearing an Internal Alkyne Group

We have achieved the nickel-catalyzed asymmetric propargylic amination of propargylic carbonates bearing an internal alkyne group. A wide variety of propargylic carbonates and N-methylaniline derivatives were tolerated under the reaction conditions, providing the corresponding chiral propargylic amines in up to 97% yield with up to 97% ee.

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Electric Literature of 33282-15-4, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 33282-15-4, molcular formula is C10H7NO4, introducing its new discovery.

A process for preparing N – methyl-P-anisidine method (by machine translation)

The invention discloses a method for preparing N – methyl-P-anisidine method, to the anisidine and methanol as the reaction raw materials, in order to molecular sieve catalyst load as the active component, at the reaction temperature of 150 – 350 C, the liquid volume airspeed is 0.1 – 2.0 h- 1 , N2 Under the condition of the gas as the carrier gas in a fixed bed continuous flow reactor for reaction, to obtain the N – methyl-P-anisidine; Cu and Ni as the active component in at least one of, its content of the catalyst is 0.01 – 30 wt %; molecular sieve as 3 A, 4 A, 5 A molecular sieve in a. The present invention has high yield, the operation is simple, mild condition, catalyst performance is stable, low cost, low pollution. (by machine translation)

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Preparation of unsymmetrical sulfonylureas from N,N?-sulfuryldiimidazoles

The synthetic methods reported in the literature for the preparation of sulfonylureas tend to be restricted in scope or unsuitable for use in parallel synthesis. We have developed a method for preparing sterically congested sulfonylureas based on N,N?-sulfuryldiimidazole that is both convenient and amenable to parallel synthesis. Sequential activation by way of alkylation of the imidazole group using methyl triflate followed by nucleophilic displacement with a variety of amines and anilines afford the unsymmetrical sulfonylurea. Sulfonylureas prepared from anilines were obtained in high yields using N,N?-sulfuryldiimidazole, while the somewhat more sterically congested analogue, N,N?-sulfurylbis-2-methylimidazole, proved to be superior for alkylamines.

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Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C10H7NO4, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 33282-15-4, Name is 5-(4-Hydroxyphenyl)isoxazole-3-carboxylic acid, molecular formula is C10H7NO4

Indium-catalyzed N -formylation of amines under solvent-free conditions

We have developed a simple, mild method for N-formylation of a wide variety of amines in the presence of indium metal as a catalyst under solvent-free conditions. This reaction is applicable to the chemoselective N-formylation of amino groups and -amino acid esters without epimerization. Georg Thieme Verlag Stuttgart.

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Isoxazole – Wikipedia,
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Triflic anhydride-mediated tandem formylation/cyclization of cyanoacetanilides: a concise synthesis of glycocitlone alkaloids

A method is presented for the concise synthesis of 3-formyl-4-hydroxyquinolin-2(1H)-ones through triflic anhydride-mediated tandem formylation/cyclization of cyanoacetanilides. This tandem process was successfully used for the rapid syntheses of glycocitlones A and C.

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Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem