Category: 2402-95-1

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Chloropyridine 1-oxide( cas:2402-95-1 ) is researched.Related Products of 2402-95-1.Liu, Rui; Liu, Shan; Zhu, Hongjun published the article 《Synthesis of 2-mercaptopyridine-1-oxide zinc salt and its crystal structure》 about this compound( cas:2402-95-1 ) in Nanjing Gongye Daxue Xuebao, Ziran Kexueban. Keywords: mercaptopyridine oxide zinc salt synthesis chloropyridine crystal structure. Let’s learn more about this compound (cas:2402-95-1).

2-Chloropyridine-N-oxide was synthesized by treating 2-chloropyridine with hydrogen peroxide in glacial acetic acid. The final product 2-mercaptopyridine-1-oxide zinc salt was obtained from 2-chloropyridine-N-oxide via reaction with NaSH, preparation of the sodium salt and chelation with ZnSO4. The structure of the product was characterized by m.p., 1HNMR and single crystal diffractometer. The crystal belonged to monoclinic space group of P21/C with a = 0.84010(17) nm, b = 1.0184(2) nm, c = 1.3736(3) nm, α = 90.00°, β = 97.23(3)°, γ = 90.00°, Dx = 1.810 g/cm3, Z = 4, F(000) = 640, μ = 2.453 mm-1, and the final deviation factor R = (0.0325) and wR = (0.0728).

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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Name: 2-Chloropyridine 1-oxide. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Chloropyridine 1-oxide, is researched, Molecular C5H4ClNO, CAS is 2402-95-1, about Study in synthesis of N-oxide-2-pyridine phenyl sulfide derivative. Author is Li, Shuyan.

N-oxide-2-pyridine Ph sulfide derivatives were prepared by mercapto-reaction of 4-methylthiophenol or 4-chlorothiophenol with N-oxide-2-chloropyridine prepared by oxygenation of 2-chloropyridine with 30% H2O2 in acetic acid. The reaction of nucleophilic displacement on the ring of 2-chloropyridine was discussed. The structures of the synthesized compounds were characterized by IR, 1H NMR, and 13C NMR.

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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Product Details of 2402-95-1. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Chloropyridine 1-oxide, is researched, Molecular C5H4ClNO, CAS is 2402-95-1, about Research on synthesis of 2-chloro-4-nitropyridine-N-oxide. Author is Li, Quanliang; Wang, Jun; Li, Shujing.

2-Chloro-4-nitropyridine-N-oxide was synthesized from 2-chloropyridine by N-oxidation and mixed acid nitrifying with one pot reaction. The intermediate yield of 2-chloropyridine-N-oxide was 96.5% when n(2-chloropyridine):n(H2O2):n(CH3COOH) = 1:3.5:1.5, the reaction temperature was 80°C and the reaction time was 3 h. Synthetic liquid proceeded nitration reaction directly after enrichment. The production yield of 2-chloro-4-nitropyridine-N-oxide was 85.8% when n(2-chloropyridine-N-oxide):n(HNO3) = 1:3.5, V(H2SO4)/V(HNO3) = 1:1, the reaction temperature was 80°C and the reaction time was 6 h. The structures of intermediate and target product were confirmed by M.p., IR, MS and elemental anal. The final product was gained.

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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Formula: C5H4ClNO. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Chloropyridine 1-oxide, is researched, Molecular C5H4ClNO, CAS is 2402-95-1, about Broad single-minimum proton potential and proton polarizability of the hydrogen bonds in trifluoroacetic acid + pyridine N-oxide systems as a function of donor and acceptor properties and environment. Infrared studies. Author is Boehner, Ulrich; Zundel, Georg.

F3CCO2H + pyridine-N-oxide (1:1) system properties were studied in CCl4 and MeCN as functions of the basicity of the N-oxide. In CCl4, acid-base complexes are formed almost completely, whereas in MeCN the degree of complex formation increases with increasing basicity of the N-oxide. In the O-…H+…ON bonds, a single-min. proton potential is present, and if the degree of symmetry of this potential is sufficiently large continua indicate that these H bonds show a large proton polarizability caused by the fluctuating proton. The broad single-min. potential well shifts with increasing basicity of the N-oxide, from the donor to the acceptor. This shift is larger in MeCN solutions than in CCl4 solutions since in the polar solvent the interaction of the H-bond dipole with the reaction field induced by it in the solvent is larger.

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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2402-95-1, is researched, Molecular C5H4ClNO, about Study on catalytic oxidation preparation of crystals of 2-mercaptopyridine N-oxide sodium, the main research direction is mercaptopyridine oxide sodium salt production.Reference of 2-Chloropyridine 1-oxide.

The title compound was prepared by oxidation of 2-chloropyridine with H2O2 in the presence of the Diels-Alder adduct of anthracene and maleic anhydride, followed by reaction with NaHS. Under optimum conditions, the overall product yield reached 63.7%.

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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Oxidation reactions using magnesium monoperphthalate: a comparison with m-chloroperoxybenzoic acid, published in 1987-11-30, which mentions a compound: 2402-95-1, mainly applied to oxidant magnesium monoperphthalate; perphthalate magnesium oxidant; chloroperoxybenzoic acid oxidant, Product Details of 2402-95-1.

Magnesium monoperphthalate hexahydrate, a newly developed reagent with high stability at ambient temperatures, has been shown to oxidize a wide range of substrates under mild conditions. The substrates include alkenes, ketones, sulfides and sulfoxides, pyridine, and dipotassium p-tolylpentafluorosilicate.

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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Category: isoxazole. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Chloropyridine 1-oxide, is researched, Molecular C5H4ClNO, CAS is 2402-95-1, about Protective role of reactive oxygen species scavengers against toxicity of 3-chloropyridine and 2-chloropyridine N-oxide. Author is Anuszewska, E. L.; Koziorowska, J. H..

The nature of biol. effects of substituted pyridines and their N-oxides is a matter for discussion. The previous study demonstrated that 3-chlopyridine is cytotoxic and clastogenic. No cytotoxic activity was observed with 2-chloropyridine tested in the same dose range. In this study experiments were performed to assess cytotoxicity and clastogenicity of 2-chloropyridine N-oxide and 3-chloropyridine N-oxide. In the dose range from 800 to 3200 μg 2-chloropyridine/mL, N-oxide showed a dose-dependent cytotoxicity and clastogenicity. In the same dose range, 3-chloropyridine N-oxide was found to be non-cytotoxic and non-clastogenic. The nature of the effects induced by 3-chloropyridine and 2-chloropyridine N-oxide was analyzed on the basis of possible protection by scavengers of reactive oxygen species. The cytotoxicity of both compounds was effectively suppressed by catalase and hydroxyl radicals scavengers. Pretreatments of V3 cells with DMSO or catalase provided protection against the ability of both compounds to induce chromosomal aberrations. From the data of this study the authors conclude that cytotoxicity and clastogenicity of 3-chloropyridine and 2-chloropyridine N-oxide are linked to the generation of reactive oxygen species.

There is still a lot of research devoted to this compound(SMILES：ClC1=CC=CC=[N+]1[O-])Category: isoxazole, and with the development of science, more effects of this compound(2402-95-1) can be discovered.

Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2402-95-1, is researched, SMILESS is ClC1=CC=CC=[N+]1[O-], Molecular C5H4ClNOJournal, Jingxi Shiyou Huagong called Synthesis of 2-chloropyridine-n-oxide on supported phosphotungstic acid catalyst, Author is Qiu, Tao; Zhao, Hongxu; Lu, Xinyu, the main research direction is chloropyridine oxide phosphotungstic acid silicon dioxide oxidation catalyst.COA of Formula: C5H4ClNO.

Phosphotungstic acid immobilized on silicon dioxide is prepared as catalyst. 2-Chloropyridine-N-oxide is synthesized from 2-chloropyridine, H2O2 and catalyst. By single factor experiment, effects of mass fraction of phosphotungstic acid, catalyst dosage, molar ratio of reactants, reaction temperature and reaction time on oxidation is studied. Through repeat examinations, the optimal reaction conditions is mass fraction of phosphotungstic acid 30%, mass of catalyst 3.3%; n(2-chloropyridine):n(H2O2)=1:6.0; reaction temperature 80°C and reaction time 30 h. The optimal yield is 89.8%.

If you want to learn more about this compound(2-Chloropyridine 1-oxide)COA of Formula: C5H4ClNO, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(2402-95-1).

Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Chloropyridine 1-oxide, is researched, Molecular C5H4ClNO, CAS is 2402-95-1, about Synthesis of 2-chloropyridine-n-oxide on supported phosphotungstic acid catalyst.Application In Synthesis of 2-Chloropyridine 1-oxide.

Phosphotungstic acid immobilized on silicon dioxide is prepared as catalyst. 2-Chloropyridine-N-oxide is synthesized from 2-chloropyridine, H2O2 and catalyst. By single factor experiment, effects of mass fraction of phosphotungstic acid, catalyst dosage, molar ratio of reactants, reaction temperature and reaction time on oxidation is studied. Through repeat examinations, the optimal reaction conditions is mass fraction of phosphotungstic acid 30%, mass of catalyst 3.3%; n(2-chloropyridine):n(H2O2)=1:6.0; reaction temperature 80°C and reaction time 30 h. The optimal yield is 89.8%.

There is still a lot of research devoted to this compound(SMILES：ClC1=CC=CC=[N+]1[O-])Application In Synthesis of 2-Chloropyridine 1-oxide, and with the development of science, more effects of this compound(2402-95-1) can be discovered.

Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

COA of Formula: C5H4ClNO. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Chloropyridine 1-oxide, is researched, Molecular C5H4ClNO, CAS is 2402-95-1, about Aqueous biphasic oxidation: a water-soluble polyoxometalate catalyst for selective oxidation of various functional groups with hydrogen peroxide. Author is Sloboda-Rozner, Dorit; Witte, Peter; Alsters, Paul L.; Neumann, Ronny.

A “”sandwich”” type polyoxometalate, Na12[WZn3(H2O)2][(ZnW9O34)2], was used as an oxidation catalyst in aqueous biphasic reaction media to effect oxidation of alcs., diols, pyridine derivatives, amines and aniline derivatives with hydrogen peroxide. The catalyst was shown by 183W NMR to be stable in aqueous solutions in the presence of H2O2 and showed only minimal non-productive decomposition of the oxidant. Secondary alcs. were selectively oxidized to ketones, while primary alcs. tended to be oxidized to the corresponding carboxylic acids, although secondary alcs. were selectively oxidized in the presence of primary alcs. Vicinal diols yielded carbon-carbon bond cleavage products in very high yields. Pyridine derivatives were oxidized to the resp. N-oxides, but strongly electron-withdrawing moieties inhibited the oxidation reaction. Primary amines were oxidized to the oximes, but significantly hydrolyzed in situ. Aniline derivatives were oxidized to the corresponding azoxy or nitro products depending on the substitution pattern in the aromatic ring. Catalyst recovery and recycle was demonstrated.

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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem