Category: 1750-42-1

Simple exploration of 1750-42-1

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1750-42-1, Isoxazol-3-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 1 mmol aldehyde, 3 volume of acetonitrile and 1 equivalent volume of aminewere added to 0.6 equivalent of quinoline derivatives and 1% (v/v) formic acid. The reaction mixturewas stirred at higher temperature (75 C). The reaction was monitored by TLC (eluent: hexaneisomeric mixture:acetone). If the product precipitated, it was filtered, washed with hexane, and dried.If the reaction mixture was homogeneous, it was evaporated to dryness and was purified by columnchromatography (eluent: hexane:acetone from 20:1 to 4:1, v/v). The crude product was crystallizedfrom hexane/ethyl-acetate. The molecular structures were determined by means of 1D and 2D-NMRtechnologies (see Supplementary Materials), 1750-42-1

Big data shows that 1750-42-1 is playing an increasingly important role.

Reference£º
Article; Kanizsai, Ivan; Madacsi, Ramona; Hackler, Laszlo; Gyuris, Mario; Szebeni, Gabor J.; Huzian, Orsolya; Puskas, Laszlo G.; Molecules; vol. 23; 8; (2018);,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

Downstream synthetic route of 1750-42-1

As the paragraph descriping shows that 1750-42-1 is playing an increasingly important role.

1750-42-1, Isoxazol-3-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 64 Preparation of 2-{3-[2-(4-chlorophenyl)ethyl]-5-oxo-1-phenyl-2-sulfanylideneimidazolidin-4-yl}-N-(1,2-oxazol-3-yl)acetamide. Oxalyl chloride (44.8 muL; 0.51 mmol; 2 eq) and dimethylformamide (0.3 mL) were added to a solution of 2-{3-[2-(4-chlorophenyl)ethyl]-5-oxo-1-phenyl-2-sulfanylideneimidazolidin-4-yl}acetic acid (1-3) (100 mg; 0.26 mmol; 1 eq) in dichloromethane (6 mL). The reaction mixture was stirred at room temperature for 3 hours. Then, pyridine (62 muL; 0.77 mmol; 3 eq) and 1,2-oxazol-3-amine (38 muL; 0.51 mmol; 2 eq) were added. The mixture was stirred at room temperature over the week-end. Saturated ammonium chloride (30 mL) was added and the aqueous layer was extracted with ethyl acetate (3 x 30 mL). The combined organic layers were washed with saturated sodium chloride (3 x 30 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure. The crude was purified on silica gel using dichloromethane/ethyl acetate (95/5 to 50/50) as an eluent. After trituration in diethyl ether and lyophilisation, the title compound 2- {3-[2-(4-chlorophenyl)ethyl]-5-oxo-1-phenyl-2-sulfanylideneimidazolidin-4-yl}-N-(1,2-oxazol-3-yl)acetamide was obtained in 25% yield (29.25 mg) as a white powder. 1H-NMR (DMSO-d6): delta (ppm) 2.89 (m, 1H), 3.03 (m, 1H), 3.18 (m, 1H), 3.39 (m, 1H), 3.71 (m, 1H), 4.17 (m, 1H), 4.8 (t, 1H), 6.9 (d, 1H), 7.32 (m, 4H), 7.38 (m, 2H), 7.48 (m, 3H), 8.81 (d, 1H), 11.34 (s, 1H); MS (ESI+): m/z = 454.8, 456.8 [M+H]+.

As the paragraph descriping shows that 1750-42-1 is playing an increasingly important role.

Reference£º
Patent; Vivalis; Guedat, Philippe; Berecibar, Amaya; Ciapetti, Paola; Venkata Pithani ,Subhash; Trouche, Nathalie; EP2664616; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem