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Herein we described an optimised synthesis of isoxazoloazepinone and novel heterocycle pyrazoloazepinone. These syntheses are modular in nature and fast to execute. The title compounds were obtained pure without the intervention of chromatography.

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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

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This chapter discusses the five-membered ring systems with O & N atoms such as isoxazoles, isoxazolines, isoxazolidines, oxazoles, oxazolines, oxazolidines, and oxadiazoles. The novel reactions, applications as synthetic intermediates or ligands, and synthetic methods of this class of heterocycles published in the calendar year 2018 are reviewed.

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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

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The enantioselective vinylogous Henry reaction of 3,5-dimethyl-4-nitroisoxazole with trifluoromethyl ketones employing a bifunctional squaramide organocatalyst has been developed. A series of isoxazole bearing trifluoromethyl-substituted tertiary alcohols, 2-substituted (R)-1,1,1-trifluoro-3-(3-methyl-4-nitroisoxazol-5-yl)propan-2-ols, were obtained under these mild reaction conditions in good yields and moderate to good enantioselectivities

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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

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A multicomponent synthesis of cyclopropanes is described. The title compounds were obtained in high yields from commercially available materials.

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Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

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A method allowing the selective oxygen labelling of aliphatic polyacids, for example, succinic and glutaric acids, is reported. This process is based on the hydrolysis of a 3-alkyl-4-nitroisoxazol-5-yl group by Na18OH and affords the products in high yields. The same procedure was applied for the preparation of labelled aliphatic carboxylic acids.

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The GIAO (Gauge Including Atomic Orbitals) DFT (Density Functional Theory) method is applied at the B3LYP/6-31+G(d,p)//B3LYP/6-31+G(d), B3LYP/6-311++G(d,p)//B3LYP/6-31+G(d), B3LYP/6-311+G (2d,p)//B3LYP/6-31+G(d) and B3LYP/6-311++G(d,p)//B3LYP/6-311++G(d,p) levels of theory for the calculation of proton and carbon chemicals shifts and coupling constants for 25 nitro-substituted five-membered heterocycles. Difference (1D NOE) spectra in combination with long-range gHMBC experiments were used as tools for the structural elucidation of nitro-substituted five-membered heterocycles. The assigned NMR data (chemical shifts and coupling constants) for all compounds were found to be in good agreement with theoretical calculations using the GIAO DFT method. The magnitudes of one-bond (1JCH) and long-range (nJCH, n > 1) coupling constants were utilized for unambiguous differentiation between regioisomers of nitro-substituted five-membered heterocycles. Copyright

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Reference:
Isoxazole – Wikipedia,
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Isoxazoles are highly effective anti-viral agents. Combinations of isoxazoles, dihydropyrimidines and/or lamivudine and, optionally, interferon inhibit the proliferation of HBV viruses better than conventional agents.

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We report a mild, fast, highly efficient and eco-friendly protocol for the green synthesis of pyrrolo[2,3-d]isoxazoles and a new series of novel benzyl bis-pyrrolo[2,3-d]isoxazoles from nitro styrylisoxazoles in SnCl 2-ionic liquid by reductive cyclization. These reactions were performed at ambient temperature which resulted in good yields in short reaction time, without requiring any organic solvent and catalyst.

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Reference:
Isoxazole – Wikipedia,
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Macrocyclic peptides are disclosed having the general formula: wherein R3, R3?, R4, R6, R?, X, Q and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

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Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

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A high yielding synthesis of polyfunctional scaffold 3-methyl-4-nitro-5-heteroarylethenylisoxazole is described. The novel condition allowed the preparation of reactive title compounds in high yield.

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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem