Category: 110256-15-0

110256-15-0, 5-Cyclopropylisoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Into a 50-mL round-bottom flask was placed racemic 5-cyclopropyl-1,2-oxazole-3-carboxylic acid (121 mg, 0.79 mmol, 1.00 equiv), tert-butyl N-[(1R,3S,4R)-4-amino-3-benzylcyclohexyl]carbamate (240 mg, 0.79 mmol, 1.00 equiv), EDCI (302 mg, 1.58 mmol, 2.00 equiv), HOBT (213 mg, 1.58 mmol, 2.00 equiv), TEA (319 mg, 3.15 mmol, 4.00 equiv), and dichloromethane (10 mL). The resulting solution was stirred at room temperature overnight. The mixture was washed with 1*10 of water and dried over anhydrous sodium sulfate. The solids were filtered out and the filtrate concentrated tinder vacuum. The residue was purified on a silica gel column with dichloromethane/methanol (50:1). This resulted in 280 mg (81%) of racemic tert-butyl N-[(1R,3S,4R)-3-benzyl-4-(5-cyclopropyl-1,2-oxazole-3-amido)cyclohexyl]carbamate as a white solid. LCMS (method D, ESI): RT=2.12 min, m/z=462.1 [M+Na]+.

The synthetic route of 110256-15-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; EPIZYME, INC.; Foley, Megan Alene Cloonan; Kuntz, Kevin Wayne; Mitchell, Lorna Helen; Munchhof, Michael John; (57 pag.)US2020/123142; (2020); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.110256-15-0,5-Cyclopropylisoxazole-3-carboxylic acid,as a common compound, the synthetic route is as follows.

A mixture of 23.0 mg (0.15 mmol) of 5-cyclopropyl-isoxazole-3-carboxylic acid, 30 mu (0.21 mmol) of triethylamine, 63.2 mg (0.18 mmol) of 1-amino- cyclopropanecarboxylic acid 4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-l -yl]- benzylamide (Reference Example 4) 60.0 mg (0.16 mmol) of HATU and 1 mL of N,N- dimethylformamide was stirred at room temperature for 24 h. The reaction mixture was purified by column chromatography using Kieselgel 60 (Merck) as adsorbent and hexane:ethyl acetate = 4: 1 as eluent to yield 26 mg (31 %) of the title compound. MS (EI) 557.2 (MH+).

As the paragraph descriping shows that 110256-15-0 is playing an increasingly important role.

Reference£º
Patent; RICHTER GEDEON NYRT.; BEKE, Gyula; BENYEI, Gyula Attila; BORZA, Istvan; BOZO, Eva; FARKAS, Sandor; HORNOK, Katalin; PAPP, Andrea; VAGO, Istvan; VASTAG, Monika; WO2012/59776; (2012); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

110256-15-0, 5-Cyclopropylisoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 24 5-Cyclopropyl-isoxazole-3-carboxylic acid (1-{4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide A mixture of 23.0 mg (0.15 mmol) of 5-cyclopropyl-isoxazole-3-carboxylic acid, 30 mul (0.21 mmol) of triethylamine, 63.2 mg (0.18 mmol) of 1-amino-cyclopropanecarboxylic acid 4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzylamide (Reference Example 4) 60.0 mg (0.16 mmol) of HATU and 1 mL of N,N-dimethylformamide was stirred at room temperature for 24 h. The reaction mixture was purified by column chromatography using Kieselgel 60 (Merck) as adsorbent and hexane:ethyl acetate=4:1 as eluent to yield 26 mg (31%) of the title compound. MS (EI) 557.2 (MH+).

The synthetic route of 110256-15-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Richter Gedeon Nyrt.; Beke, Gyula; Benyei, Gyula Attila; Borza, Istvan; Bozo, Eva; Farkas, Sandor; Hornok, Katalin; Papp, Andrea; Vago, Istvan; Vastag, Monika; US2013/217702; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem