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Isothiazolium salts were allowed to react with a number of nitrogen nucleophiles including ammonia, hydrazine, phenylhydrazine, hydroxylamine, and benzylamine.The products obtained suggest that the position of initial nucleophilic attack is at the sulphur atom of the heterocyclic cation.

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Propylphosphonic anhydride has been demonstrated to be an efficient reagent for the transformation of aromatic, heteroaromatic, and aliphatic aldehydes to respective nitriles in excellent yields. This procedure offers simple and one-pot access to nitriles and highlights the synthetic utility of T3P as a versatile reagent in organic chemistry. Georg Thieme Verlag Stuttgart – New York.

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The ozonolysis of substituted isoxazoles was investigated.The ozonolysis rates and the products were dependent on the site of the substituent group on isoxazole ring.The reaction mechanism of the ozonolysis of isoxazoles was also proposed.

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The cycloadducts from trimethylsilanecarbonitrile oxide and ethylenic or acetylenic compounds easily rearrange to open-chain intermediates, which, in turn, are hydrolysed respectively to beta-hydroxynitriles and beta-oxonitriles.The cycloadducts of the same nitrile oxide with sulfur dioxide and sulfinylamines are unstable, too, leading respectively to trimethylsilylisocyanate and trimethylsilylcarbodiimides.All these reactions are of preparative interest, in comparison with previous methods.

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Tertiary cyclopropanols, when treated with an excess of amyl nitrite at room temperature, are smoothly converted into dimeric beta-nitrosoketones. Heating the methanolic solutions of the latter under reflux gives 5-substituted isoxazoles in good yields. Georg Thieme Verlag Stuttgart.

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2-aryl-4-isoxazolin-3-one derivatives

2-aryl-4-isoxazolin-3-1-derivatives of formula (I), useful as intermediates for positive working compounds in silver halide photographic materials STR1 wherein R1 represents a substituted or unsubstituted alkyl having from 1 to 6 carbon atoms or a substituted or unsubstituted aryl having from 6 to 24 carbon atoms; and R2, R3, and R4, are the same or different, each having up to 20 carbon atoms and each represents hydrogen, a substituted or unsubstituted alkoxy, a substituted or unsubstituted aryloxy, a substituted or unsubstituted acyl, a substituted or unsubstituted alkoxycarbonyl, a substituted or unsubstituted aryloxycarbonyl, halogen, nitro, a substituted or unsubstituted carbamoyl, a substituted or unsubstituted sulfamoyl, a substituted or unsubstituted sulfonyl, cyano, or trifluoromethyl, with the proviso that at least one of said R2 and R3 is cyano, a substituted or unsubstituted sulfonyl, trifluoromethyl, or nitro.

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Isoxazole – Wikipedia,
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Methodology for the Synthesis of 3-Acyltetramic Acids

A general method for the preparation of 3-acyltetramic acids is described.The methodology can be extended to produce 3-enoyl or 3-dienoyl substituents via a Wadsworth-Emmons olefination sequence.

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DIAZEPINE DERIVATIVES AS 5-HT2A ANTAGONISTS

Compounds of formula I: are selective 5HT2A antagonists and hence find use in treatment or prevention of a variety of CNS disorders.

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Isoxazole – Wikipedia,
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CHIRAL ACETYLENES AS SYNTHETIC INTERMEDIATES. V. A REINVESTIGATION ON THE SYNTHESIS OF OPTICALLY ACTIVE ISOXAZOLES

The synthesis of 3- or 5-alkyl isoxazoles and pyrazoles has been achieved starting from alkyl-substituted acetylenic ketones: the influence of the structure of the carbonyl compound on the isomeric composition of the heterocyclic compound has been studied.Some optically active monoalkyl-substituted isoxazoles have also been prepared: in this context, an investigation on the stereochemistry of the cyclization process has been carried out.

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Isoxazole | C3H3NO – PubChem

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Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel antiproliferative agents: Exploration of core and headpiece structure-activity relationships

A novel series of antiproliferative agents containing pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides, selective for p21-deficient cells, were identified by high-throughput screening. Exploration of the SAR relationships in the headpiece, core, and tailpiece is described. Strict steric, positional, and electronic requirements were observed, with a clear preference for both core nitrogens, a thienoyl headpiece, and meta substituted tailpiece.

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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem